| Probe | Locus(GRCh37) | Gene | Region | p-val | Trait | PubMed ID |
| cg06700877 | chr10:104169610 | PSD | 3.400e-9 | Smoking | 27651444 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| PDZD4 | 0.969 |
| NCS1 | 0.964 |
| FBXL16 | 0.959 |
| SEPT5 | 0.953 |
| RUNDC3A | 0.949 |
| BAP1 | 0.946 |
| JPH3 | 0.942 |
| DLG4 | 0.941 |
| AGAP3 | 0.938 |
| MAP3K10 | 0.935 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| OR4F5 | -0.753 |
| OR4F29 | -0.698 |
| SGMS2 | -0.379 |
| ANXA13 | -0.372 |
| VRK2 | -0.36 |
| TFPI2 | -0.349 |
| CNTF | -0.341 |
| KCNJ15 | -0.336 |
| DTHD1 | -0.333 |
| KIAA0040 | -0.329 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C029790 | 2,2',3',4,4',5-hexachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD mRNA" | 25510870 |
| C081766 | 2,4,4'-trichlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD mRNA" | 25510870 |
| C014024 | 2,4,5,2',4',5'-hexachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD mRNA" | 25510870 |
| C009828 | 2,4,5,2',5'-pentachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD mRNA" | 25510870 |
| C009407 | 2,5,2',5'-tetrachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD mRNA" | 25510870 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of PSD mRNA | 17562736 |
| D000535 | Aluminum | [APP protein modified form binds to Aluminum] which results in decreased expression of PSD mRNA | 21298039 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of PSD mRNA | 16483693 |
| D001241 | Aspirin | Aspirin results in increased expression of PSD mRNA | 11906190 |
| C547126 | AZM551248 | AZM551248 results in decreased expression of PSD mRNA | 22323515 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of PSD mRNA | 21839799 |
| D004958 | Estradiol | Estradiol results in increased expression of PSD mRNA | 20068009 |
| C006780 | bisphenol A | bisphenol A affects the expression of PSD mRNA | 25181051 |
| C584509 | C646 compound | C646 compound results in decreased expression of PSD mRNA | 26191083 |
| D019327 | Copper Sulfate | Copper Sulfate results in increased expression of PSD mRNA | 19549813 |
| D003471 | Cuprizone | Cuprizone results in decreased expression of PSD mRNA | 26577399 |
| D003976 | Diazinon | Diazinon results in increased methylation of PSD gene | 22964155 |
| C492448 | ICG 001 | ICG 001 results in decreased expression of PSD mRNA | 26191083 |
| D007657 | Ketone Bodies | Ketone Bodies results in increased expression of PSD mRNA | 16807920 |
| D007854 | Lead | Lead affects the expression of PSD mRNA | 28903495 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium results in increased expression of PSD mRNA | 22776087 |
| C410127 | PCB 180 | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD mRNA" | 25510870 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of PSD mRNA | 23557933 |
| C017947 | sodium arsenite | sodium arsenite affects the methylation of PSD gene | 28589171 |
| C501413 | tesaglitazar | tesaglitazar results in decreased expression of PSD mRNA | 21515302 |
| C009495 | titanium dioxide | titanium dioxide results in increased expression of PSD mRNA | 23557971 |
| C057693 | troglitazone | troglitazone results in decreased expression of PSD mRNA | 17569031 |
| C057693 | troglitazone | troglitazone results in decreased expression of PSD mRNA | 21515302 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in increased methylation of PSD gene | 25560391 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | - | IDA | 23603394 |
| GO:0005515 | protein binding | - | IPI | 20339350 |
| GO:0005543 | phospholipid binding | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0007165 | signal transduction | - | NAS | 9417912 |
| GO:0031175 | neuron projection development | - | IEA | - |
| GO:0032012 | regulation of ARF protein signal transduction | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0014069 | postsynaptic density | - | IEA | - |
| GO:0032154 | cleavage furrow | - | IDA | 23603394 |
| GO:0032587 | ruffle membrane | - | IDA | 23603394 |
| GO:0043197 | dendritic spine | - | IEA | - |
| GO:0098999 | extrinsic component of postsynaptic endosome membrane | - | IEA | - |
| KEGG ID | KEGG Term |
|---|---|
| hsa04144 | Endocytosis |
| Reactome ID | Reactome Term | Evidence |
|---|
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 20336176 | The Role of AMPAR Trafficking Mediated by Neuronal Pentraxins in Cocaine-induced Neuroadaptations. (2009 May 6) | Pacchioni AM | Mol Cell Pharmacol |
| 27894930 | Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences. (2017 Jan) | Marco EM | Pharmacol Biochem Behav |
| 25769285 | Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. (2015 Mar) | Staples MC | Mol Cell Neurosci |
| 22033836 | Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus. (2012 Mar) | Parameshwaran K | Cell Mol Life Sci |
| 23546937 | Chronic alcoholism-mediated impairment in the medulla oblongata: a mechanism of alcohol-related mortality in traumatic brain injury? (2013) | Lai XP | Cell Biochem Biophys |
| 25601500 | Deterministic effects after fenestrated endovascular aortic aneurysm repair. (2015 Apr) | Kirkwood ML | J Vasc Surg |
| 14749431 | Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. (2004 Jan 28) | Morabito MA | J Neurosci |
| 22548195 | Kalirin, a key player in synapse formation, is implicated in human diseases. (2012) | Mandela P | Neural Plast |
| 19557105 | Cognitive impairment after cerebrovascular stroke: Relationship to vascular risk factors. (2009) | Khedr EM | Neuropsychiatr Dis Treat |
| 11167288 | Defective visual field tests in chronic heavy smokers. (2001 Feb) | Hepsen IF | Acta Ophthalmol Scand |
| 24667898 | Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. (2015) | Kim A | Brain Struct Funct |
| 20018661 | Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. (2010 Jan 5) | Thorsen TS | Proc Natl Acad Sci U S A |
| 24704371 | Epigenetic upregulation of PSD-95 contributes to the rewarding behavior by morphine conditioning. (2014 Jun 5) | Wang Z | Eur J Pharmacol |
| 7686471 | The effects of ethanol on EEG activity in males at risk for alcoholism. (1993 Jun) | Cohen HL | Electroencephalogr Clin Neurophysiol |
| 25145782 | Ocular and systemic factors associated with glaucoma in chronic kidney disease patients. (2014 Nov) | Djordjevic-Jocic J | Int Urol Nephrol |
| 17325440 | Absent post-ischemic increase of blood flowmotion in the cutaneous microcirculation of healthy chronic cigarette smokers. (2007) | Rossi M | Clin Hemorheol Microcirc |
| 23867772 | Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine? (2013 Oct 22) | Villalba RM | Neuroscience |
| 17481661 | Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics. (2008 Apr) | Karolewicz B | J Psychiatr Res |
| 24397780 | Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95. (2015 Mar) | Daut RA | Addict Biol |
| 27898427 | Cocaine Withdrawal Reduces Gamma-Aminobutyric Acid-Ergic Transmission and Gephyrin Expression at Medial Prefrontal Cortex in Cocaine-Conditioned Place-Preference Rats, Which Shows Increased Cocaine Seeking. (2017) | Yang W | Eur Addict Res |
| 25532598 | Cardiac autonomic changes in middle-aged women: identification based on principal component analysis. (2016 Jul) | Trevizani GA | Clin Physiol Funct Imaging |
| 29089442 | Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms. (2017 Dec 6) | Burgdorf CE | J Neurosci |
| 12457264 | Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit. (2002 Dec) | Loftis JM | Psychopharmacology (Berl) |