Gene: TMPRSS4

56649
CAPH2|MT-SP2|TMPRSS3
transmembrane serine protease 4
protein-coding
11q23.3
Ensembl:ENSG00000137648 MIM:606565 Vega:OTTHUMG00000164122 UniprotKB:Q9NRS4
NG_011858.2
SNP Mapped
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.739e-1 (AD)  9.977e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINB30.649
SPRR2F0.624
GBP60.619
CSTA0.608
ADH70.601
SPINK50.6
DAZ10.591
UGT1A70.58
TMPRSS11E0.573
PADI10.572

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSPH-0.233
ANKRD55-0.201
FAM86B2-0.2
KIT-0.199
ZC2HC1C-0.194
BTBD8-0.191
DUSP19-0.19
C1orf53-0.188
NWD1-0.183
FAM173B-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of TMPRSS4 mRNA"18281256
D000082AcetaminophenAcetaminophen affects the expression of TMPRSS4 mRNA17562736
D001280AtrazineAtrazine results in increased expression of TMPRSS4 mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TMPRSS4 mRNA26377693
C075388beta-damascenonebeta-damascenone results in increased expression of TMPRSS4 mRNA22982537
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMPRSS4 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TMPRSS4 mRNA19619570|2118537
C006780bisphenol Abisphenol A results in decreased expression of TMPRSS4 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TMPRSS4 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMPRSS4 mRNA20938992
D003300CopperCopper deficiency results in increased expression of TMPRSS4 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of TMPRSS4 mRNA26033743
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TMPRSS4 mRNA26865667
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TMPRSS4 mRNA17942748
C082360fipronilfipronil results in increased expression of TMPRSS4 mRNA27091632
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMPRSS4 mRNA20938992
C039281furanfuran results in increased expression of TMPRSS4 mRNA27387713
D019833GenisteinGenistein affects the expression of TMPRSS4 mRNA26865667
D007052IbuprofenIbuprofen affects the expression of TMPRSS4 mRNA17070997
C008261lead acetatelead acetate results in increased expression of TMPRSS4 mRNA22609695
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TMPRSS4 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMPRSS4 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of TMPRSS4 mRNA18502557
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TMPRSS4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TMPRSS4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TMPRSS4 mRNA"25554681
D009532NickelNickel results in increased expression of TMPRSS4 mRNA25583101
D052638Particulate MatterParticulate Matter results in increased expression of TMPRSS4 mRNA28341207
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMPRSS4 mRNA19710929
C116926rofecoxibrofecoxib results in increased expression of TMPRSS4 mRNA17070997
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TMPRSS4 mRNA26378955
D013629TamoxifenTamoxifen results in decreased expression of TMPRSS4 mRNA25123088
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMPRSS4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TMPRSS4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMPRSS4 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TMPRSS4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMPRSS4 mRNA20159946
C009495titanium dioxidetitanium dioxide results in increased expression of TMPRSS4 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TMPRSS4 mRNA20133372
D014212TretinoinTretinoin results in increased expression of TMPRSS4 mRNA23830798
D014635Valproic AcidValproic Acid results in increased expression of TMPRSS4 mRNA24383497
C025643vinclozolinvinclozolin results in decreased expression of TMPRSS4 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-NAS10825129  
GO:0005044scavenger receptor activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-NAS10825129  
GO:0006898receptor-mediated endocytosis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-NAS10825129  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal