Gene: CLDND1

56650
C3orf4|GENX-3745|Z38
claudin domain containing 1
protein-coding
3q11.2
Ensembl:ENSG00000080822 Vega:OTTHUMG00000160050 UniprotKB:Q9NY35
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.009e-1 (AD)  5.080e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18754985chr3:98237750CLDND17.700e-12Smoking27651444
cg00385142chr3:98235918CLDND14.700e-8Smoking27651444
cg18754985chr3:98237750CLDND11.380e-11Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIP4K2A0.968
PLP10.942
SLC44A10.932
SLAIN10.929
FAM107B0.928
PLA2G160.923
CFL20.92
ERMN0.917
CNP0.913
GOLGA70.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.492
CHRNA2-0.445
OR4F5-0.441
CUX2-0.427
SHISA8-0.401
SSTR4-0.391
SP8-0.386
LTK-0.384
CNGB1-0.383
PCDH8-0.379

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of CLDND1 mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CLDND1 mRNA19933214
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CLDND1 mRNA"23196670
D000082AcetaminophenAcetaminophen results in increased expression of CLDND1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CLDND1 gene27153756
C430898AGN 194204AGN 194204 results in decreased expression of CLDND1 mRNA16339527
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of CLDND1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLDND1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLDND1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CLDND1 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of CLDND1 mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of CLDND1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of CLDND1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CLDND1 mRNA21297351
C018021cobaltous chloridecobaltous chloride results in increased expression of CLDND1 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CLDND1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of CLDND1 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of CLDND1 mRNA17211630
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CLDND1 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of CLDND1 mRNA28302478
D005485FlutamideFlutamide results in increased expression of CLDND1 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of CLDND1 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CLDND1 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CLDND1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CLDND1 mRNA24435446
C410337K 7174K 7174 results in increased expression of CLDND1 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of CLDND1 mRNA16807920
C051752nefazodonenefazodone results in increased expression of CLDND1 mRNA24136188
C012655nimesulidenimesulide results in increased expression of CLDND1 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CLDND1 mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of CLDND1 mRNA22124623
D010416PentachlorophenolPentachlorophenol results in increased expression of CLDND1 mRNA23892564
D010936Plant ExtractsPlant Extracts results in increased expression of CLDND1 mRNA23557933
D011374ProgesteroneProgesterone affects the expression of CLDND1 mRNA17251523
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDND1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLDND1 mRNA15667827|1869160
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CLDND1 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of CLDND1 mRNA26217789
C012589trichostatin Atrichostatin A affects the expression of CLDND1 mRNA28542535
D014520UrethaneUrethane results in increased expression of CLDND1 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0009986cell surface-HDA19581412  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23210427A whole blood gene expression-based signature for smoking status. (2012 Dec 3)Beineke PBMC Med Genomics