Gene: NPDC1

56654
CAB|CAB-|CAB-1|CAB1|NPDC-1
neural proliferation, differentiation and control 1
protein-coding
9q34.3
Ensembl:ENSG00000107281 MIM:605798 Vega:OTTHUMG00000020956 UniprotKB:Q9NQX5
NC_000009.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.440e-1 (AD)  9.520e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB11B0.945
VPS280.939
MAP2K20.938
TMEM2050.938
GPS10.936
MRPL380.933
TCEA20.931
NAA100.931
DGAT10.931
WBP20.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.798
OR4F29-0.773
KCNJ15-0.315
FOLR3-0.304
CEACAM3-0.294
TFPI2-0.287
PABPC4L-0.287
KLRB1-0.286
MTRNR2L9-0.276
DNASE1L3-0.276

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NPDC1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NPDC1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NPDC1 mRNA"25380136
C0293704-toluidine4-toluidine results in increased expression of NPDC1 mRNA27638505
D000082AcetaminophenAcetaminophen affects the expression of NPDC1 mRNA17562736
D000068180AripiprazoleAripiprazole results in decreased expression of NPDC1 mRNA17868501
D001280AtrazineAtrazine results in decreased expression of NPDC1 mRNA22378314
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NPDC1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPDC1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of NPDC1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of NPDC1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NPDC1 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of NPDC1 mRNA18958704
D002104CadmiumCadmium results in increased expression of NPDC1 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NPDC1 mRNA25993096
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPDC1 mRNA20938992
D019327Copper SulfateCopper Sulfate affects the expression of NPDC1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of NPDC1 mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NPDC1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of NPDC1 mRNA18042831|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NPDC1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NPDC1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NPDC1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of NPDC1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NPDC1 mRNA19638242
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NPDC1 mRNA17557909
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPDC1 mRNA20938992
C039281furanfuran results in increased expression of NPDC1 mRNA25539665|2619464
D005897GlafenineGlafenine results in increased expression of NPDC1 mRNA24136188
D006118GriseofulvinGriseofulvin affects the expression of NPDC1 mRNA12735108
D017313FenretinideFenretinide results in decreased expression of NPDC1 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NPDC1 mRNA17183730
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NPDC1 mRNA23086925
C410337K 7174K 7174 results in increased expression of NPDC1 mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPDC1 mRNA20938992
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of NPDC1 mRNA25380136
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NPDC1 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of NPDC1 mRNA18042831
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NPDC1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of NPDC1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of NPDC1 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of NPDC1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of NPDC1 mRNA23811191
D010894PiroxicamPiroxicam results in decreased expression of NPDC1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in decreased expression of NPDC1 mRNA23557933
D012402RotenoneRotenone results in decreased expression of NPDC1 mRNA19013527
D013739TestosteroneTestosterone results in increased expression of NPDC1 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPDC1 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NPDC1 mRNA21215274
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of NPDC1 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of NPDC1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NPDC1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NPDC1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of NPDC1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of NPDC1 mRNA19042947
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NPDC1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of NPDC1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of NPDC1 gene29154799
D014640VancomycinVancomycin results in decreased expression of NPDC1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of NPDC1 mRNA19165385
C025643vinclozolinvinclozolin results in increased expression of NPDC1 mRNA22570695|2303416
C029297vinylidene chloridevinylidene chloride results in increased expression of NPDC1 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of NPDC1 mRNA27188386
D015034Zinc OxideZinc Oxide analog results in decreased expression of NPDC1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25555412Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. (2015 Sep)Weng JTComput Biol Med