Gene info: ID 567

Gene: B2M

GENE ID: 567

Synonyms: IMD43

Description: beta-2-microglobulin

Gene type: protein-coding

Location: 15q21.1

dbXrefs: Ensembl:ENSG00000166710 MIM:109700 Vega:OTTHUMG00000131247 UniprotKB:P61769

RefSeq: NG_012920.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 9

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.599e-2 (AD) 1.616e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HLA-B	0.943
HLA-A	0.921
PSMB8	0.908
MYL12A	0.899
HLA-E	0.894
PSME1	0.878
PSMB9	0.877
ANXA5	0.874
IFITM1	0.849
HLA-C	0.84

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.533
OR4F5	-0.5
ADRA1D	-0.412
ABCC12	-0.396
MARCH4	-0.395
KCNB2	-0.39
CALHM1	-0.389
SLC7A4	-0.387
OPRD1	-0.384
HTR6	-0.383

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00254	Doxycycline	Small Molecule	564-25-0	Approved\|Investigational	Target
DB02740	3-Indolebutyric Acid	Small Molecule	133-32-4	Experimental	Target
DB04464	N-Formylmethionine	Small Molecule		Experimental	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target
DB11130	Opium	Small Molecule	8008-60-4	Approved\|Illicit	Carrier

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of B2M mRNA"	19114083
C078765	2,3,5-(triglutathion-S-yl)hydroquinone	"2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of B2M mRNA"	14587099
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of B2M mRNA"	20206263
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of B2M mRNA	21983209
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of B2M mRNA	19191707
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of B2M mRNA	17011747
C029370	4-toluidine	4-toluidine results in decreased expression of B2M mRNA	27638505
C576268	6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide	"6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog inhibits the reaction [Dihydrotestosterone results in increased expression of B2M mRNA]"	27720946
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of B2M mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in increased expression of B2M protein	17642144
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [B2M protein modified form results in increased abundance of Reactive Oxygen Species]	21864514
D000111	Acetylcysteine	Acetylcysteine results in decreased susceptibility to B2M protein modified form	21864514
D000119	Acetylmuramyl-Alanyl-Isoglutamine	Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of B2M protein	15905553
D000119	Acetylmuramyl-Alanyl-Isoglutamine	Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of B2M protein	15905553
D000171	Acrolein	Acrolein results in decreased expression of B2M mRNA	28482051
C053001	adefovir	adefovir results in increased secretion of B2M protein	27742868
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of B2M mRNA"	19410594
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of B2M protein"	24679086
D013196	Dihydrotestosterone	"6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog inhibits the reaction [Dihydrotestosterone results in increased expression of B2M mRNA]"	27720946
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of B2M mRNA	27720946
D000617	Aminoglycosides	Aminoglycosides results in increased secretion of B2M protein	6142864
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of B2M mRNA	16483693
D000728	Androgens	Androgens results in increased expression of and results in increased secretion of B2M protein	17404077
D000728	Androgens	Androgens results in increased expression of B2M mRNA	17404077
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of B2M mRNA	24449571
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of B2M protein	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of B2M protein	23912714
D001151	Arsenic	Arsenic results in increased expression of B2M protein	24679086
D001194	Asbestos	Asbestos results in decreased expression of B2M mRNA	22398240
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of B2M mRNA	15372504
D001241	Aspirin	Aspirin results in increased expression of B2M mRNA	15456535
D001262	Atenolol	Atenolol results in decreased expression of B2M protein	2656332
D001280	Atrazine	Atrazine results in decreased expression of B2M mRNA	22982499
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of B2M mRNA	20127859\|2222880
D004958	Estradiol	Estradiol results in decreased expression of B2M mRNA	23019147
D004958	Estradiol	Estradiol results in increased expression of B2M mRNA	21185374
D004958	Estradiol	Estradiol affects the expression of B2M mRNA	16684588
C044887	beta-methylcholine	beta-methylcholine affects the expression of B2M mRNA	21179406
C495703	bis(2-chloroethoxy)methane	bis(2-chloroethoxy)methane results in decreased expression of B2M mRNA	16844662
C006780	bisphenol A	bisphenol A results in increased expression of B2M mRNA	25181051
C025703	bleomycetin	bleomycetin results in decreased expression of B2M mRNA	21040473
D000069286	Bortezomib	Bortezomib results in decreased expression of B2M protein	17204182
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of B2M mRNA	18804290
D020148	Butyric Acid	Butyric Acid results in decreased stability of B2M mRNA	1693837
D002104	Cadmium	Cadmium affects the secretion of B2M protein	22995156
D002104	Cadmium	Cadmium results in increased expression of B2M protein	22027495
D002104	Cadmium	MT1A gene polymorphism affects the reaction [Cadmium affects the secretion of B2M protein]	22995156
D002104	Cadmium	Cadmium results in increased expression of B2M mRNA	17327699
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of B2M mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of B2M mRNA	17327699
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of B2M mRNA	15963578
C026690	cerous chloride	cerous chloride results in increased expression of B2M mRNA	28954213
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of B2M mRNA	18804290
C100187	chloropicrin	chloropicrin affects the expression of B2M mRNA	26352163
C100187	chloropicrin	chloropicrin results in decreased expression of B2M mRNA	28476498
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of B2M mRNA	28472532
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of B2M mRNA	28219650
D003300	Copper	Copper binds to and results in decreased folding of and results in decreased stability of B2M protein	16513784
D003300	Copper	Copper promotes the reaction [B2M protein binds to B2M protein]	17254602
D003300	Copper	Urea promotes the reaction [Copper promotes the reaction [B2M protein binds to B2M protein]]	17254602
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of B2M mRNA	15467011
D003300	Copper	MT1 affects the reaction [Copper results in increased expression of B2M mRNA]	16629173
D003300	Copper	MT2 affects the reaction [Copper results in increased expression of B2M mRNA]	16629173
D003375	Coumestrol	Coumestrol results in increased expression of B2M mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of B2M mRNA	18550754
D003471	Cuprizone	Cuprizone results in increased expression of B2M mRNA	27523638
D003561	Cytarabine	Cytarabine results in increased expression of B2M protein	11096300
C014347	decitabine	decitabine affects the expression of B2M mRNA	23300844
C014347	decitabine	decitabine results in increased expression of B2M protein	19294695
C014347	decitabine	decitabine results in increased expression of B2M mRNA	27915011
D003907	Dexamethasone	Dexamethasone results in decreased expression of B2M protein	3047540
D003907	Dexamethasone	Dexamethasone results in increased expression of B2M mRNA	21041162
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of B2M mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of B2M mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of B2M mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of B2M protein	28904298
C000944	dicrotophos	dicrotophos results in decreased expression of B2M mRNA	28302478
C121718	dicyclanil	dicyclanil results in increased expression of B2M mRNA	15664270
D004041	Dietary Fats	Dietary Fats results in decreased expression of B2M mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in decreased expression of B2M protein	19680557
D004041	Dietary Fats	Dietary Fats results in increased expression of B2M mRNA	25016146
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of B2M mRNA	27614199
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate affects the expression of B2M mRNA	27405655
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of B2M mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of B2M mRNA]	17942915
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of B2M mRNA	21041162
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of B2M mRNA	21658437
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of B2M mRNA	17011747
D002117	Calcitriol	Calcitriol results in increased expression of B2M protein	8807625
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of B2M mRNA	28219650
D004237	Diuron	Diuron results in decreased expression of B2M mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in increased secretion of B2M protein	28885000
C118739	entinostat	entinostat results in increased expression of B2M mRNA	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of B2M mRNA	12655031
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of B2M	15967208
D000431	Ethanol	B2M gene mutant form results in decreased susceptibility to Ethanol	21309947
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of B2M mRNA	17606305
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of B2M mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of B2M mRNA	17557909
D005054	Eugenol	Eugenol results in increased expression of B2M mRNA	17936526
C017690	fenvalerate	fenvalerate affects the expression of B2M mRNA	20003521
D005485	Flutamide	Flutamide results in decreased expression of B2M mRNA	24136188
D005492	Folic Acid	Folic Acid affects the expression of B2M mRNA	17868486
D005557	Formaldehyde	Formaldehyde results in increased expression of B2M mRNA	12679049
C039281	furan	furan results in decreased expression of B2M mRNA	26194646
C027235	gallium nitrate	gallium nitrate results in decreased expression of B2M mRNA	18586083
D019833	Genistein	Genistein results in increased expression of B2M mRNA	21782745
D005839	Gentamicins	Gentamicins results in increased expression of B2M protein	2218653
D005839	Gentamicins	Gentamicins results in increased expression of B2M protein	28904298
D005839	Gentamicins	Gentamicins results in increased expression of B2M mRNA	22061828
D005839	Gentamicins	Gentamicins results in increased expression of B2M protein	26779593
D005839	Gentamicins	Gentamicins results in increased secretion of B2M protein	20816719
D005839	Gentamicins	Sodium Fluoride inhibits the reaction [Gentamicins results in increased expression of B2M protein]	26779593
D005897	Glafenine	Glafenine results in decreased expression of B2M mRNA	24136188
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of B2M mRNA	22634610
C001335	hexachlorobutadiene	hexachlorobutadiene results in increased expression of B2M protein	21259293\|2202081
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of B2M mRNA	21179406
D007069	Ifosfamide	Ifosfamide results in increased expression of B2M protein	8625085\|9261752
C051890	irinotecan	irinotecan results in increased expression of B2M mRNA	20097248
D007501	Iron	[HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron	16841247
D007501	Iron	B2M protein affects the metabolism of Iron	17194590
D048628	Ketolides	Ketolides analog results in increased expression of B2M mRNA	24967691
C028521	lanthanum chloride	lanthanum chloride results in increased expression of B2M mRNA	28954213
D007854	Lead	Lead affects the expression of B2M mRNA	28903495
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of B2M mRNA"	18930950
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of B2M mRNA	20353558
D008627	Mercuric Chloride	B2M protein affects the reaction [Mercuric Chloride results in increased expression of IFNG mRNA]	21793797
D008627	Mercuric Chloride	B2M protein affects the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]	21793797
D017669	Mercury Compounds	Mercury Compounds results in decreased expression of B2M protein	22715704
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of B2M mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of B2M mRNA	28001369
D015741	Metribolone	Metribolone results in increased expression of and results in increased secretion of B2M protein	17404077
D015741	Metribolone	Metribolone results in increased expression of B2M mRNA	17131305\|1740407
D015741	Metribolone	resveratrol inhibits the reaction [Metribolone results in increased expression of B2M mRNA]	18586690
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of B2M mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of B2M mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of B2M mRNA"	25620056
C000621033	napabucasin	napabucasin results in decreased expression of B2M mRNA	25605917
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of B2M mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of B2M mRNA	24136188
D009532	Nickel	Nickel results in increased expression of B2M mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in increased expression of B2M mRNA	19167457
C012655	nimesulide	nimesulide results in decreased expression of B2M mRNA	24136188
D009569	Nitric Oxide	Nitric Oxide results in increased expression of B2M protein	15764486
D005996	Nitroglycerin	Nitroglycerin affects the expression of B2M protein	8350464
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of B2M mRNA	17616710
D009793	Ochratoxins	Ochratoxins results in increased secretion of B2M protein	20816719
D010126	Ozone	Ozone results in decreased expression of B2M mRNA	12763052
D000073878	Palm Oil	Palm Oil results in decreased expression of B2M mRNA	18042831
D000073878	Palm Oil	Palm Oil results in decreased expression of B2M protein	19680557
C019248	pamidronate	pamidronate results in decreased expression of B2M protein	11683535
D052638	Particulate Matter	Particulate Matter results in increased expression of B2M mRNA	23638009
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of B2M protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of B2M mRNA	18804290
D010634	Phenobarbital	Phenobarbital results in increased expression of B2M mRNA	12082028
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of B2M mRNA	26272509
D010695	Phlorhizin	Phlorhizin results in increased expression of B2M mRNA	22538082
C030090	phosphoramide mustard	phosphoramide mustard results in decreased expression of B2M mRNA	27888070
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of B2M mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of B2M mRNA	17426115\|2081375
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of B2M mRNA	22714537
C009007	potassium persulfate	potassium persulfate results in increased expression of B2M protein	20815409
D017382	Reactive Oxygen Species	Acetylcysteine inhibits the reaction [B2M protein modified form results in increased abundance of Reactive Oxygen Species]	21864514
D017382	Reactive Oxygen Species	B2M protein modified form results in increased abundance of Reactive Oxygen Species	21864514
C059514	resveratrol	resveratrol inhibits the reaction [Metribolone results in increased expression of B2M mRNA]	18586690
D012266	Ribose	Ribose results in increased glycation of B2M protein	21864514
C541923	sandostatinLAR	sandostatinLAR results in increased expression of B2M mRNA	17210224
D012524	Sarin	Sarin results in decreased expression of B2M mRNA	19522546
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of B2M mRNA	19073995
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of B2M mRNA	18685790
C009277	sodium arsenate	sodium arsenate results in decreased expression of B2M mRNA	23922661
C016104	sodium bichromate	sodium bichromate results in decreased expression of B2M mRNA	22155349
C028982	sodium chromate(VI)	sodium chromate(VI) results in increased expression of B2M protein	2202081
D012969	Sodium Fluoride	Sodium Fluoride inhibits the reaction [Gentamicins results in increased expression of B2M protein]	26779593
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of B2M protein	23933529
C013698	tallow	tallow results in decreased expression of B2M protein	19680557
D013629	Tamoxifen	Tamoxifen results in increased expression of B2M mRNA	19155303
D013629	Tamoxifen	Tamoxifen affects the expression of B2M mRNA	17555576
D013739	Testosterone	Testosterone results in increased expression of B2M mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of B2M mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of B2M mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of B2M mRNA	19465110\|2386450
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of B2M mRNA	21041162
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of B2M mRNA	16466705
C009495	titanium dioxide	titanium dioxide results in increased expression of B2M mRNA	23557971\|2776080
D014031	Tobramycin	Tobramycin results in increased expression of B2M protein	2218653
D014118	Toxins, Biological	"Toxins, Biological affects the expression of B2M mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of B2M mRNA	17218384
D014212	Tretinoin	Tretinoin results in increased expression of B2M mRNA	16604517
C012589	trichostatin A	trichostatin A results in increased expression of B2M mRNA	15901671
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of B2M mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in increased expression of B2M mRNA	15901671
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of B2M mRNA"	18930950
D014501	Uranium	Uranium affects the expression of B2M mRNA	15672453
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of B2M mRNA	19654044
C005460	uranyl acetate	uranyl acetate affects the expression of B2M mRNA	15672453
D014508	Urea	Urea promotes the reaction [Copper promotes the reaction [B2M protein binds to B2M protein]]	17254602
D014635	Valproic Acid	Valproic Acid results in increased expression of B2M mRNA	15901671
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of B2M mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of B2M gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of B2M mRNA	23179753\|2352703
D014635	Valproic Acid	Valproic Acid results in increased expression of B2M mRNA	15901671
D014640	Vancomycin	Vancomycin results in decreased expression of B2M mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of B2M gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in increased expression of B2M mRNA	26682919
C111237	vorinostat	vorinostat results in increased expression of B2M mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	9465039 9546397 9990067 11502003 12118248 12244049 12833155 14764708 15723809 15965644 18802093 20164429 20618438 23051753 23527218 24163410 26439010 27649529
GO:0042802	identical protein binding	-	IPI	17108084 18579777 19172750 19564620 20826442 21131979 21220305 21569201 22289140 22575645

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001895	retina homeostasis	-	HEP	23580065
GO:0001916	positive regulation of T cell mediated cytotoxicity	-	IEA	-
GO:0002237	response to molecule of bacterial origin	-	IEA	-
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	TAS	-
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	-
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	-	TAS	-
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	-	IEA	-
GO:0002726	positive regulation of T cell cytokine production	-	IDA	24643698
GO:0010977	negative regulation of neuron projection development	-	IEA	-
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	-	IGI	24643698
GO:0032092	positive regulation of protein binding	-	IGI	18353247
GO:0033077	T cell differentiation in thymus	-	IEA	-
GO:0033216	ferric iron import	-	IEA	-
GO:0042026	protein refolding	-	IEA	-
GO:0042493	response to drug	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0045087	innate immune response	-	TAS	-
GO:0045646	regulation of erythrocyte differentiation	-	IEA	-
GO:0046686	response to cadmium ion	-	IEA	-
GO:0048260	positive regulation of receptor-mediated endocytosis	-	IGI	18353247
GO:0050690	regulation of defense response to virus by virus	-	TAS	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0055072	iron ion homeostasis	-	IC	18353247
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	-
GO:0071281	cellular response to iron ion	-	IGI	18353247
GO:0071283	cellular response to iron(III) ion	-	IEA	-
GO:1900121	negative regulation of receptor binding	-	IDA	9465039
GO:1900122	positive regulation of receptor binding	-	IGI	18353247
GO:1900390	regulation of iron ion import	-	IGI	18353247
GO:1904434	positive regulation of ferrous iron binding	-	IGI	18353247
GO:1904437	positive regulation of transferrin receptor binding	-	IGI	18353247

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	TAS	-
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470 22664934
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005794	Golgi apparatus	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0030670	phagocytic vesicle membrane	-	TAS	-
GO:0031901	early endosome membrane	-	TAS	-
GO:0031905	early endosome lumen	-	TAS	-
GO:0035580	specific granule lumen	-	TAS	-
GO:0042612	MHC class I protein complex	-	IEA	-
GO:0055038	recycling endosome membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 23533145
GO:1904724	tertiary granule lumen	-	TAS	-
GO:1990712	HFE-transferrin receptor complex	-	IDA	9990067

KEGG ID	KEGG Term
hsa04612	Antigen processing and presentation

Reactome ID	Reactome Term	Evidence
R-HSA-1236974	ER-Phagosome pathway	TAS
R-HSA-1236974	ER-Phagosome pathway	IEA
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1236975	Antigen processing-Cross presentation	IEA
R-HSA-1236977	Endosomal/Vacuolar pathway	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1643685	Disease	TAS
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	TAS
R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression	TAS
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-2172127	DAP12 interactions	TAS
R-HSA-2172127	DAP12 interactions	IEA
R-HSA-2424491	DAP12 signaling	TAS
R-HSA-2424491	DAP12 signaling	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-877300	Interferon gamma signaling	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-977225	Amyloid fiber formation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24683472	Cardiovascular risk markers associated with arterial calcification in patients with chronic kidney disease Stages 3 and 4. (2014 Apr)	Kiu Weber CI	Clin Kidney J
14976454	The exposure to cadmium, lead and mercury from smoking and its impact on renal integrity. (2004 Mar)	Mortada WI	Med Sci Monit
15688855	Renal dysfunction of cadmium-exposed workers residing in a cadmium-polluted environment. (2004 Oct)	Jin T	Biometals
26908438	Circulating Beta-2 Microglobulin and Risk of Cancer: The Atherosclerosis Risk in Communities Study (ARIC). (2016 Apr)	Prizment AE	Cancer Epidemiol Biomarkers Prev
25303803	Clinical utility of serum beta-2-microglobulin as a predictor of diabetic complications in patients with type 2 diabetes without renal impairment. (2014 Dec)	Kim MK	Diabetes Metab
7068238	Biological assessment of exposure in factories with second degree usage of cadmium compounds. (1982 Feb)	Wibowo AA	Int Arch Occup Environ Health
28490653	Prospective association between beta2-microglobulin levels and ischemic stroke risk among women. (2017 Jun 6)	Rist PM	Neurology
27663042	Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in CKD. (2016 Dec)	Liu X	Am J Kidney Dis
25286916	Low-level cadmium exposure and effects on kidney function. (2014 Dec)	Wallin M	Occup Environ Med