Gene: IFNK

56832
IFNT1|INFE1
interferon kappa
protein-coding
9p21.2
Ensembl:ENSG00000147896 MIM:615326 Vega:OTTHUMG00000019715 UniprotKB:Q9P0W0
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.224e-1 (AD)  4.266e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR56A40.918
PRDM140.911
PRAMEF170.909
OR10K10.903
TAS2R410.899
TAS2R300.896
POU5F20.893
TMEM2470.885
OR9Q20.884
OR2A140.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL22-0.308
CENPH-0.306
NPM3-0.294
HDDC3-0.292
NUDT6-0.291
C11orf80-0.282
METTL2A-0.277
PDSS2-0.27
ACRV1-0.268
CHEK1-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IFNK mRNA24449571
C006780bisphenol Abisphenol A results in decreased expression of IFNK mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of IFNK gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of IFNK promoter22457795
D003474CurcuminCurcumin results in decreased expression of IFNK mRNA18421014
D004041Dietary FatsDietary Fats results in decreased expression of IFNK mRNA25016146
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of IFNK mRNA23876855
C017947sodium arsenitesodium arsenite results in decreased expression of IFNK mRNA23876855
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IFNK mRNA23152189
D014241TrichloroethyleneTrichloroethylene results in increased methylation of IFNK gene27618143
D014635Valproic AcidValproic Acid results in decreased methylation of IFNK gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IFNK gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005132type I interferon receptor binding-IBA21873635  
GO:0005132type I interferon receptor binding-IDA11514542  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IBA21873635  
GO:0002286T cell activation involved in immune response-IBA21873635  
GO:0002323natural killer cell activation involved in immune response-IBA21873635  
GO:0006355regulation of transcription, DNA-templated-IDA11514542  
GO:0006959humoral immune response-IBA21873635  
GO:0008285negative regulation of cell proliferation-NAS11514542  
GO:0009615response to virus-IEP11514542  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-IDA11514542  
GO:0030101natural killer cell activation-NAS11514542  
GO:0030183B cell differentiation-IBA21873635  
GO:0033141positive regulation of peptidyl-serine phosphorylation of STAT protein-IBA21873635  
GO:0042100B cell proliferation-IBA21873635  
GO:0043330response to exogenous dsRNA-IBA21873635  
GO:0045089positive regulation of innate immune response-TAS11514542  
GO:0051607defense response to virus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IC11514542  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04622RIG-I-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23376709A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. (2013 Jul)Kerns SLJ Urol