Gene info: ID 56848

Gene: SPHK2

GENE ID: 56848

Synonyms: SK 2|SK-2|SPK 2|SPK-2

Description: sphingosine kinase 2

Gene type: protein-coding

Location: 19q13.33

dbXrefs: Ensembl:ENSG00000063176 MIM:607092 Vega:OTTHUMG00000183318 UniprotKB:Q9NRA0

RefSeq: NG_029867.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.417e-1 (AD) 7.592e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg17865555	chr19:49133647	SPHK2	3'UTR	7.039e-6	Alcohol use disorders	26763658
cg21519787	chr19:49133421	SPHK2	3'UTR	5.395e-4	Alcohol use disorders	26763658
cg17865555	chr19:49133647	SPHK2		5.050e-10	Smoking	28686328
cg21519787	chr19:49133421	SPHK2		5.650e-9	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PANX2	0.945
ZBTB7A	0.928
FBXL19	0.917
LIMK1	0.916
TTLL12	0.916
LYNX1	0.915
NAT8L	0.912
RNF157	0.91
ARHGEF4	0.908
PPFIA3	0.908

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.605
OR4F29	-0.553
CST7	-0.481
IL18RAP	-0.48
PROK2	-0.463
KCNJ15	-0.456
TFPI2	-0.456
S100A12	-0.455
C1orf87	-0.451
BEST3	-0.446

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased expression of SPHK2 mRNA	19435785
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SPHK2 mRNA"	27291303
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SPHK2 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of SPHK2 mRNA"	21346803
C548780	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide results in decreased activity of SPHK2 protein	26719367
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of SPHK2 mRNA"	21346803
D020106	Acrylamide	Acrylamide results in increased expression of SPHK2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SPHK2 mRNA	19770486
D001280	Atrazine	Atrazine results in decreased expression of SPHK2 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SPHK2 mRNA	26238291
C013418	bromfenacoum	bromfenacoum results in decreased expression of SPHK2 protein	28903499
C018475	butyraldehyde	butyraldehyde results in decreased expression of SPHK2 mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of SPHK2 mRNA	26191083
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SPHK2 mRNA	17341687
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of SPHK2 mRNA	23650126
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SPHK2 gene	20938992
C018021	cobaltous chloride	SPHK2 results in increased susceptibility to cobaltous chloride	23043544
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SPHK2 mRNA	23640034
D004317	Doxorubicin	SPHK2 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]	17974990
D004317	Doxorubicin	SPHK2 protein results in increased susceptibility to Doxorubicin	17974990
D018120	Finasteride	Finasteride results in increased expression of SPHK2 mRNA	24136188
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]	24859201
D000068876	Fingolimod Hydrochloride	SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]	24859201
D000068876	Fingolimod Hydrochloride	SPHK2 protein results in increased phosphorylation of Fingolimod Hydrochloride	24859201
D000068876	Fingolimod Hydrochloride	SPHK2 results in increased susceptibility to Fingolimod Hydrochloride	23043544
D000068876	Fingolimod Hydrochloride	SPHK2 protein results in increased phosphorylation of Fingolimod Hydrochloride	26719367
D000068876	Fingolimod Hydrochloride	[SPHK2 protein results in increased phosphorylation of Fingolimod Hydrochloride] which results in increased abundance of Fingolimod Hydrochloride metabolite	26719367
D005485	Flutamide	Flutamide results in increased expression of SPHK2 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SPHK2 gene	20938992
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of SPHK2 mRNA	20044591
D007545	Isoproterenol	Isoproterenol results in decreased expression of SPHK2 mRNA	20003209
D007854	Lead	Lead affects the expression of SPHK2 mRNA	22313790
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of SPHK2 mRNA"	24972896
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SPHK2 gene	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of SPHK2 mRNA	17400583
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SPHK2 mRNA	26011545
D009151	Mustard Gas	Mustard Gas results in increased expression of SPHK2 mRNA	15674844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SPHK2 mRNA"	25620056
C051752	nefazodone	nefazodone results in increased expression of SPHK2 mRNA	24136188
C022838	nickel chloride	nickel chloride affects the expression of SPHK2 mRNA	22546817
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of SPHK2 mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT analog results in decreased expression of SPHK2 mRNA"	22937105
C016340	o,p'-DDT	"o,p'-DDT results in decreased expression of SPHK2 mRNA"	22937105
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of SPHK2 mRNA"	24096037
D010100	Oxygen	SPHK2 results in increased susceptibility to Oxygen deficiency	23043544
D010634	Phenobarbital	Phenobarbital results in decreased expression of SPHK2 mRNA	19270015
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SPHK2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of SPHK2 mRNA	17426115
D010936	Plant Extracts	Plant Extracts results in decreased expression of SPHK2 mRNA	23557933
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SPHK2 mRNA	28903501
D011374	Progesterone	Progesterone results in decreased expression of SPHK2 mRNA	23012394
C045950	propiconazole	propiconazole results in decreased expression of SPHK2 mRNA	21278054
C031280	pyrazole	pyrazole results in decreased expression of SPHK2 mRNA	17945193
D018038	Sodium Selenite	Sodium Selenite results in increased expression of SPHK2 mRNA	18175754
D016559	Tacrolimus	Tacrolimus results in decreased expression of SPHK2 mRNA	25270620
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of SPHK2 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SPHK2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SPHK2 mRNA	28213091
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SPHK2 mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SPHK2 mRNA	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SPHK2 mRNA	19520675
C009495	titanium dioxide	titanium dioxide results in decreased expression of SPHK2 mRNA	23409001
D014635	Valproic Acid	Valproic Acid affects the expression of SPHK2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased methylation of SPHK2 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of SPHK2 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SPHK2 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of SPHK2 mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003951	NAD+ kinase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	11777919
GO:0005524	ATP binding	-	IEA	-
GO:0008481	sphinganine kinase activity	-	NAS	10751414
GO:0008481	sphinganine kinase activity	-	TAS	-
GO:0017016	Ras GTPase binding	-	NAS	12391145
GO:0017050	D-erythro-sphingosine kinase activity	-	TAS	-
GO:0038036	sphingosine-1-phosphate receptor activity	-	IMP	23106337

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001568	blood vessel development	-	IEA	-
GO:0003376	sphingosine-1-phosphate signaling pathway	-	IEA	-
GO:0006669	sphinganine-1-phosphate biosynthetic process	-	NAS	10751414
GO:0007420	brain development	-	IEA	-
GO:0007565	female pregnancy	-	IEA	-
GO:0008283	cell proliferation	-	NAS	10751414
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0030148	sphingolipid biosynthetic process	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	NAS	10751414
GO:0046512	sphingosine biosynthetic process	-	IGI	23106337
GO:0046512	sphingosine biosynthetic process	-	IMP	23106337
GO:0046834	lipid phosphorylation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005765	lysosomal membrane	-	HDA	17897319
GO:0005829	cytosol	-	IDA	10751414
GO:0005829	cytosol	-	TAS	-
GO:0016020	membrane	-	IDA	10751414
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term
hsa00600	Sphingolipid metabolism
hsa01100	Metabolic pathways
hsa04020	Calcium signaling pathway
hsa04370	VEGF signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1660661	Sphingolipid de novo biosynthesis	TAS
R-HSA-428157	Sphingolipid metabolism	TAS
R-HSA-556833	Metabolism of lipids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26485657	Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). (2015)	Barnawi J	PLoS One