Gene info: ID 5685

Gene: PSMA4

GENE ID: 5685

Synonyms: HC9|HsT17706|PSC9

Description: proteasome subunit alpha 4

Gene type: protein-coding

Location: 15q25.1

dbXrefs: Ensembl:ENSG00000041357 MIM:176846 Vega:OTTHUMG00000143859 UniprotKB:P25789

RefSeq: NC_000015.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.430e-1 (AD) 1.000e-12 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GNL3	0.958
PSMA1	0.955
ENY2	0.95
PSMA6	0.948
CDC42	0.946
PSMC2	0.941
PSMA5	0.941
TAF9	0.939
PSMD14	0.939
SSB	0.938

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.694
OR4F29	-0.658
MTRNR2L6	-0.288
MTRNR2L9	-0.28
ZBTB20	-0.259
P2RY14	-0.259
NKAIN3	-0.259
WDR38	-0.256
MTRNR2L10	-0.256
KCNK5	-0.253

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB08515	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of PSMA4 mRNA"	15375163
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PSMA4 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PSMA4 mRNA"	21346803
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of PSMA4 mRNA	15890375
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PSMA4 mRNA	12958071
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of PSMA4 mRNA	24140754
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of PSMA4 mRNA"	18648102
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMA4 mRNA	15890375
D000082	Acetaminophen	Acetaminophen affects the expression of PSMA4 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of PSMA4 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PSMA4 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in increased expression of PSMA4 protein	16687475
D020106	Acrylamide	Acrylamide results in increased expression of PSMA4 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PSMA4 mRNA	15890375
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of PSMA4 mRNA"	23195993
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PSMA4 mRNA	16483693
D001554	Benzene	Benzene affects the expression of PSMA4 mRNA	15878777
C006780	bisphenol A	bisphenol A affects the expression of PSMA4 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of PSMA4 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of PSMA4 mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of PSMA4 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of PSMA4 mRNA	18804290
D002104	Cadmium	Cadmium inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PSMA4 protein]	29107029
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PSMA4 mRNA	18804290
D002273	Carcinogens	Carcinogens results in increased expression of PSMA4 mRNA	16316942
C099555	CD 437	CD 437 results in decreased expression of PSMA4 mRNA	12958071
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of PSMA4 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PSMA4 mRNA	23650126
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of PSMA4 mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of PSMA4 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PSMA4 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in increased expression of PSMA4 mRNA	21318169
C000944	dicrotophos	dicrotophos results in decreased expression of PSMA4 mRNA	28302478
D004026	Dieldrin	Dieldrin results in increased expression of PSMA4 mRNA	20438755
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of PSMA4 mRNA	21318169
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of PSMA4 mRNA	15890375
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of PSMA4 mRNA	15890375
D004317	Doxorubicin	Doxorubicin results in increased metabolism of PSMA4 protein	17346995
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of PSMA4 mRNA	19118595
D000431	Ethanol	Ethanol affects the expression of PSMA4 mRNA	24355176
D000431	Ethanol	Ethanol results in increased expression of PSMA4 protein	23702218
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PSMA4 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PSMA4 mRNA	16174780\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMA4 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PSMA4 mRNA	12655037
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PSMA4 mRNA	16174780\|2409603
D018120	Finasteride	Finasteride results in increased expression of PSMA4 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of PSMA4 mRNA	24136188
D005839	Gentamicins	Gentamicins results in increased expression of PSMA4 mRNA	22061828
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of PSMA4 mRNA	17183730
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PSMA4 mRNA	25613284
C410337	K 7174	K 7174 results in decreased expression of PSMA4 mRNA	24086573
D001556	Lindane	Lindane results in decreased expression of PSMA4 mRNA	18804290
D008345	Manganese	Manganese results in increased expression of PSMA4 mRNA	18284614
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of PSMA4 mRNA	20353558
D008701	Methapyrilene	Methapyrilene results in increased expression of PSMA4 mRNA	15890375
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of PSMA4 mRNA	18804290
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PSMA4 mRNA	26011545
D009151	Mustard Gas	Mustard Gas affects the expression of PSMA4 mRNA	15651846
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PSMA4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PSMA4 mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of PSMA4 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of PSMA4 mRNA	23195993
C029938	nickel sulfate	nickel sulfate results in decreased expression of PSMA4 mRNA	18651567
C012655	nimesulide	nimesulide results in increased expression of PSMA4 mRNA	24136188
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of PSMA4 mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT affects the expression of PSMA4 mRNA"	17984292
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of PSMA4 mRNA"	24096037
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of PSMA4 mRNA	18636392
D017239	Paclitaxel	PSMA4 protein affects the susceptibility to Paclitaxel	16217747
D052638	Particulate Matter	Particulate Matter results in decreased expression of PSMA4 mRNA	15046786
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of PSMA4 mRNA	23892564
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of PSMA4 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of PSMA4 mRNA	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of PSMA4 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of PSMA4 mRNA	18804290
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PSMA4 mRNA	19162173\|2131816
D010634	Phenobarbital	Phenobarbital results in increased expression of PSMA4 mRNA	19162173
D010695	Phlorhizin	Phlorhizin results in decreased expression of PSMA4 mRNA	22538082
D010852	Picrotoxin	Picrotoxin results in decreased expression of PSMA4 mRNA	15170462
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of PSMA4 mRNA	15890375\|2248451
C006253	pirinixic acid	pirinixic acid results in increased expression of PSMA4 mRNA	15375163\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of PSMA4 mRNA	15890375
C443641	poly(propyleneimine)	poly(propyleneimine) analog results in increased expression of PSMA4 mRNA	16308212
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of PSMA4 mRNA	19162173\|2131816
C031280	pyrazole	pyrazole results in increased expression of PSMA4 mRNA	17945193
D015474	Isotretinoin	Isotretinoin results in decreased expression of PSMA4 mRNA	20436886
D020123	Sirolimus	Sirolimus results in decreased expression of PSMA4 mRNA	11355896
C080703	SK&F 83959	SK&F 83959 results in increased expression of PSMA4 protein	25852303
C009277	sodium arsenate	sodium arsenate results in increased expression of PSMA4 mRNA	16882884
D013605	T-2 Toxin	T-2 Toxin affects the expression of PSMA4 protein	26141394
D013629	Tamoxifen	Tamoxifen affects the expression of PSMA4 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Cadmium inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PSMA4 protein]	29107029
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PSMA4 protein	29107029
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PSMA4 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMA4 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PSMA4 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PSMA4 mRNA	25613284
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PSMA4 mRNA	19042947
D014501	Uranium	Uranium affects the expression of PSMA4 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of PSMA4 mRNA	15672453
C406224	valdecoxib	valdecoxib results in increased expression of PSMA4 mRNA	24136188
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of PSMA4 mRNA	17183730
D014635	Valproic Acid	Valproic Acid results in increased expression of PSMA4 mRNA	21318169
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of PSMA4 mRNA	15046786

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004175	endopeptidase activity	-	IBA	21873635
GO:0004298	threonine-type endopeptidase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	12376572 14733938 15225636 15887188 17948026 19581590 22801492 25416956 25599644 29568061

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	-
GO:0010498	proteasomal protein catabolic process	-	IBA	21873635
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	-	IBA	21873635
GO:0016032	viral process	-	IEA	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IBA	21873635
GO:0043687	post-translational protein modification	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000502	proteasome complex	-	IDA	17323924
GO:0000932	P-body	-	ISS	-
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005839	proteasome core complex	-	IBA	21873635
GO:0005839	proteasome core complex	-	ISS	-
GO:0019773	proteasome core complex, alpha-subunit complex	-	IBA	21873635
GO:0019773	proteasome core complex, alpha-subunit complex	-	ISS	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	19056867 20458337

KEGG ID	KEGG Term
hsa03050	Proteasome

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	IEA
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	TAS
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	TAS
R-HSA-1236974	ER-Phagosome pathway	IEA
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1236975	Antigen processing-Cross presentation	IEA
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-169911	Regulation of Apoptosis	IEA
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	TAS
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	TAS
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	TAS
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	TAS
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	TAS
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	TAS
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	TAS
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	TAS
R-HSA-180534	Vpu mediated degradation of CD4	TAS
R-HSA-180585	Vif-mediated degradation of APOBEC3G	TAS
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	IEA
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2262749	Cellular response to hypoxia	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	TAS
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	TAS
R-HSA-351202	Metabolism of polyamines	TAS
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382556	ABC-family proteins mediated transport	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-4086400	PCP/CE pathway	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	TAS
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453276	Regulation of mitotic cell cycle	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-4608870	Asymmetric localization of PCP proteins	TAS
R-HSA-4641257	Degradation of AXIN	TAS
R-HSA-4641258	Degradation of DVL	TAS
R-HSA-5357801	Programmed Cell Death	IEA
R-HSA-5358346	Hedgehog ligand biogenesis	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5358351	Signaling by Hedgehog	IEA
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	TAS
R-HSA-5387390	Hh mutants abrogate ligand secretion	TAS
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5610780	Degradation of GLI1 by the proteasome	TAS
R-HSA-5610783	Degradation of GLI2 by the proteasome	IEA
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	TAS
R-HSA-5610787	Hedgehog 'off' state	IEA
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5632684	Hedgehog 'on' state	TAS
R-HSA-5658442	Regulation of RAS by GAPs	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	TAS
R-HSA-5678895	Defective CFTR causes cystic fibrosis	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689603	UCH proteinases	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	TAS
R-HSA-68867	Assembly of the pre-replicative complex	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-68949	Orc1 removal from chromatin	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	TAS
R-HSA-69052	Switching of origins to a post-replicative state	TAS
R-HSA-69202	Cyclin E associated events during G1/S transition	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69541	Stabilization of p53	TAS
R-HSA-69563	p53-Dependent G1 DNA Damage Response	TAS
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	TAS
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	TAS
R-HSA-69610	p53-Independent DNA Damage Response	TAS
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	TAS
R-HSA-69615	G1/S DNA Damage Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	TAS
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	TAS
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA
R-HSA-8939902	Regulation of RUNX2 expression and activity	TAS
R-HSA-8941858	Regulation of RUNX3 expression and activity	TAS
R-HSA-8948751	Regulation of PTEN stability and activity	TAS
R-HSA-8951664	Neddylation	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	IEA
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24518713	Association between TGM5, PPAP2B and PSMA4 polymorphisms and NSCLC in never-smoking Chinese population. (2013 Oct-Dec)	Yongjun Zhang MM	J Cancer Res Ther
20554942	Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. (2010 Aug 4)	Amos CI	J Natl Cancer Inst
26220977	A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. (2015 Oct 15)	Hancock DB	Hum Mol Genet
22832964	Genome-wide meta-analyses of smoking behaviors in African Americans. (2012 May 22)	David SP	Transl Psychiatry
29422661	Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics. (2018 May)	Nedeljkovic I	Eur J Hum Genet
18385676	Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. (2008 May)	Amos CI	Nat Genet