Gene info: ID 56852

Gene: RAD18

GENE ID: 56852

Synonyms: RNF73

Description: RAD18, E3 ubiquitin protein ligase

Gene type: protein-coding

Location: 3p25.3

dbXrefs: Ensembl:ENSG00000070950 MIM:605256 Vega:OTTHUMG00000090545 UniprotKB:Q9NS91

RefSeq: NC_000003.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.186e-1 (AD) 4.666e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DNAJC10	0.871
PPIP5K2	0.865
YTHDC2	0.862
ODF2L	0.859
RINT1	0.851
ZNF449	0.851
TSNAX	0.849
ZWILCH	0.849
SLC37A3	0.848
ZNF720	0.846

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C7orf61	-0.467
FOXJ1	-0.43
WDR38	-0.409
CCDC102A	-0.401
EYA2	-0.4
MIA	-0.398
ROM1	-0.391
FXYD3	-0.387
AKR1C3	-0.386
S100A1	-0.38

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RAD18 mRNA"	22698814
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RAD18 mRNA"	19114083
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA"	23681119
C029955	2-nitrotoluene	2-nitrotoluene results in decreased expression of RAD18 protein	22434383
C006757	4-biphenylamine	4-biphenylamine results in decreased expression of RAD18 mRNA	24857880
C006757	4-biphenylamine	4-biphenylamine results in decreased expression of RAD18 protein	24857880
C029370	4-toluidine	4-toluidine results in increased expression of RAD18 mRNA	27638505
D000082	Acetaminophen	Acetaminophen results in increased expression of RAD18 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of RAD18 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of RAD18 mRNA	23630614
D001151	Arsenic	Arsenic results in decreased expression of RAD18 mRNA	22641096
C015001	arsenite	arsenite results in decreased expression of RAD18 mRNA	18929588
D001280	Atrazine	Atrazine results in increased expression of RAD18 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RAD18 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RAD18 mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RAD18 mRNA	20713471
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAD18 mRNA"	19150397\|2038263
C006780	bisphenol A	bisphenol A affects the expression of RAD18 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of RAD18 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of RAD18 mRNA	26982218
C546611	brevetoxin 2	brevetoxin 2 results in increased expression of RAD18 mRNA	20498034
D002509	Cephaloridine	Cephaloridine results in increased expression of RAD18 mRNA	18500788
D003300	Copper	Copper results in decreased expression of RAD18 mRNA	22641096
D003375	Coumestrol	Coumestrol results in increased expression of RAD18 mRNA	19167446
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RAD18 mRNA]	27941970
D015946	Ethylene Dibromide	Ethylene Dibromide results in decreased expression of RAD18 protein	22434383
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of RAD18 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of RAD18 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of RAD18 mRNA	21151649
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RAD18 mRNA	22129741
D002117	Calcitriol	Calcitriol results in decreased expression of RAD18 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of RAD18 mRNA	21592394
D004317	Doxorubicin	Doxorubicin results in decreased expression of RAD18 mRNA	27181935
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of RAD18 mRNA]	27181935
C012976	flumequine	"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA"	23681119
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of RAD18 mRNA]	27181935
C039281	furan	furan results in increased expression of RAD18 mRNA	22079235
D017313	Fenretinide	Fenretinide results in increased expression of RAD18 mRNA	28973697
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RAD18 mRNA	22129741
D007213	Indomethacin	Indomethacin results in decreased expression of RAD18 mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RAD18 mRNA	25613284
D007854	Lead	Lead results in decreased expression of RAD18 mRNA	22641096
D008094	Lithium	Lithium results in decreased expression of RAD18 mRNA	22641096
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RAD18 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] affects the expression of RAD18 mRNA	26378955
D008628	Mercury	Mercury results in decreased expression of RAD18 mRNA	22641096
D008694	Methamphetamine	Methamphetamine results in decreased expression of RAD18 mRNA	26307267
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of RAD18 mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of RAD18 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of RAD18 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of RAD18 mRNA	22641096
C025589	ochratoxin A	ochratoxin A results in increased expression of RAD18 mRNA	18417182\|2335814
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD18 mRNA	25729387
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of RAD18 mRNA	23892564
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of RAD18 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in increased expression of RAD18 mRNA	18301758\|2081375
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of RAD18 mRNA]	21318169
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of RAD18 protein	23718831
D011374	Progesterone	Progesterone results in decreased expression of RAD18 mRNA	23018184
C031280	pyrazole	pyrazole results in increased expression of RAD18 mRNA	17945193
C059514	resveratrol	resveratrol results in decreased expression of RAD18 protein	25505154
D012402	Rotenone	Rotenone results in increased expression of RAD18 mRNA	18191903
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of RAD18 mRNA	25895662
C009277	sodium arsenate	sodium arsenate results in decreased expression of RAD18 mRNA	23922661
C017947	sodium arsenite	sodium arsenite affects the methylation of RAD18 gene	28589171
C016104	sodium bichromate	sodium bichromate results in increased expression of RAD18 mRNA	25993096
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RAD18 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] affects the expression of RAD18 mRNA	26378955
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of RAD18 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of RAD18 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RAD18 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RAD18 promoter]	19654925
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RAD18 mRNA	25613284
D013849	Thimerosal	Thimerosal results in increased expression of RAD18 mRNA	27188386
D013853	Thioacetamide	Thioacetamide results in increased expression of RAD18 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of RAD18 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of RAD18 mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD18 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of RAD18 mRNA	20530235
C012589	trichostatin A	trichostatin A results in decreased expression of RAD18 mRNA	24935251
D014635	Valproic Acid	Valproic Acid affects the expression of RAD18 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of RAD18 mRNA	23179753\|2718838
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of RAD18 gene	25560391
C111237	vorinostat	vorinostat results in increased expression of RAD18 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000403	Y-form DNA binding	-	IDA	18363965
GO:0003684	damaged DNA binding	-	NAS	10884424
GO:0005515	protein binding	-	IPI	18316726 18719106 19549727 21422291 21659603 22036607 22681887 25416956 25931565 26496610
GO:0031593	polyubiquitin modification-dependent protein binding	-	IDA	22742833
GO:0031625	ubiquitin protein ligase binding	-	IPI	10908344 18363965
GO:0042802	identical protein binding	-	IDA	25023518
GO:0043142	single-stranded DNA-dependent ATPase activity	-	IBA	21873635
GO:0044877	protein-containing complex binding	-	IPI	25931565
GO:0046872	metal ion binding	-	IEA	-
GO:0061630	ubiquitin protein ligase activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006281	DNA repair	-	NAS	10884424
GO:0006301	postreplication repair	-	IBA	21873635
GO:0006513	protein monoubiquitination	-	IBA	21873635
GO:0006974	cellular response to DNA damage stimulus	-	IDA	22036607 25023518 25931565
GO:0009411	response to UV	-	IBA	21873635
GO:0016567	protein ubiquitination	-	TAS	-
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	-
GO:0051865	protein autoubiquitination	-	IDA	25023518
GO:0051984	positive regulation of chromosome segregation	-	IMP	25931565
GO:0060548	negative regulation of cell death	-	IDA	22036607

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	15632077 22036607 25023518
GO:0005634	nucleus	-	NAS	10884424
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005657	replication fork	-	IDA	18363965
GO:0005737	cytoplasm	-	IEA	-
GO:0005813	centrosome	-	IDA	15632077
GO:0016604	nuclear body	-	IDA	-
GO:0035861	site of double-strand break	-	IDA	25931565
GO:0042405	nuclear inclusion body	-	IDA	22036607
GO:0097505	Rad6-Rad18 complex	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-8852135	Protein ubiquitination	TAS
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26683928	Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection. (2015 Dec)	Rhie A	Medicine (Baltimore)