Gene: RAD18

56852
RNF73
RAD18, E3 ubiquitin protein ligase
protein-coding
3p25.3
Ensembl:ENSG00000070950 MIM:605256 Vega:OTTHUMG00000090545 UniprotKB:Q9NS91
NC_000003.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.186e-1 (AD)  4.666e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJC100.871
PPIP5K20.865
YTHDC20.862
ODF2L0.859
RINT10.851
ZNF4490.851
TSNAX0.849
ZWILCH0.849
SLC37A30.848
ZNF7200.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C7orf61-0.467
FOXJ1-0.43
WDR38-0.409
CCDC102A-0.401
EYA2-0.4
MIA-0.398
ROM1-0.391
FXYD3-0.387
AKR1C3-0.386
S100A1-0.38

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RAD18 mRNA"22698814
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RAD18 mRNA"19114083
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA"23681119
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of RAD18 protein22434383
C0067574-biphenylamine4-biphenylamine results in decreased expression of RAD18 mRNA24857880
C0067574-biphenylamine4-biphenylamine results in decreased expression of RAD18 protein24857880
C0293704-toluidine4-toluidine results in increased expression of RAD18 mRNA27638505
D000082AcetaminophenAcetaminophen results in increased expression of RAD18 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RAD18 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RAD18 mRNA23630614
D001151ArsenicArsenic results in decreased expression of RAD18 mRNA22641096
C015001arsenitearsenite results in decreased expression of RAD18 mRNA18929588
D001280AtrazineAtrazine results in increased expression of RAD18 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RAD18 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAD18 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAD18 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAD18 mRNA"19150397|2038263
C006780bisphenol Abisphenol A affects the expression of RAD18 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RAD18 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of RAD18 mRNA26982218
C546611brevetoxin 2brevetoxin 2 results in increased expression of RAD18 mRNA20498034
D002509CephaloridineCephaloridine results in increased expression of RAD18 mRNA18500788
D003300CopperCopper results in decreased expression of RAD18 mRNA22641096
D003375CoumestrolCoumestrol results in increased expression of RAD18 mRNA19167446
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RAD18 mRNA]27941970
D015946Ethylene DibromideEthylene Dibromide results in decreased expression of RAD18 protein22434383
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RAD18 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RAD18 mRNA21266533
D002945CisplatinCisplatin results in increased expression of RAD18 mRNA21151649
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RAD18 mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of RAD18 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of RAD18 mRNA21592394
D004317DoxorubicinDoxorubicin results in decreased expression of RAD18 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of RAD18 mRNA]27181935
C012976flumequine"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA"23681119
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of RAD18 mRNA]27181935
C039281furanfuran results in increased expression of RAD18 mRNA22079235
D017313FenretinideFenretinide results in increased expression of RAD18 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RAD18 mRNA22129741
D007213IndomethacinIndomethacin results in decreased expression of RAD18 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RAD18 mRNA25613284
D007854LeadLead results in decreased expression of RAD18 mRNA22641096
D008094LithiumLithium results in decreased expression of RAD18 mRNA22641096
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RAD18 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of RAD18 mRNA26378955
D008628MercuryMercury results in decreased expression of RAD18 mRNA22641096
D008694MethamphetamineMethamphetamine results in decreased expression of RAD18 mRNA26307267
D008777MethyltestosteroneMethyltestosterone results in decreased expression of RAD18 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RAD18 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RAD18 mRNA"25554681
D009532NickelNickel results in decreased expression of RAD18 mRNA22641096
C025589ochratoxin Aochratoxin A results in increased expression of RAD18 mRNA18417182|2335814
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD18 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of RAD18 mRNA23892564
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of RAD18 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of RAD18 mRNA18301758|2081375
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of RAD18 mRNA]21318169
D011192Potassium DichromatePotassium Dichromate results in decreased expression of RAD18 protein23718831
D011374ProgesteroneProgesterone results in decreased expression of RAD18 mRNA23018184
C031280pyrazolepyrazole results in increased expression of RAD18 mRNA17945193
C059514resveratrolresveratrol results in decreased expression of RAD18 protein25505154
D012402RotenoneRotenone results in increased expression of RAD18 mRNA18191903
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RAD18 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of RAD18 mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of RAD18 gene28589171
C016104sodium bichromatesodium bichromate results in increased expression of RAD18 mRNA25993096
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RAD18 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of RAD18 mRNA26378955
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of RAD18 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of RAD18 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAD18 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RAD18 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RAD18 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of RAD18 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of RAD18 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of RAD18 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RAD18 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD18 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of RAD18 mRNA20530235
C012589trichostatin Atrichostatin A results in decreased expression of RAD18 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of RAD18 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RAD18 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RAD18 gene25560391
C111237vorinostatvorinostat results in increased expression of RAD18 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000403Y-form DNA binding-IDA18363965  
GO:0003684damaged DNA binding-NAS10884424  
GO:0005515protein binding-IPI18316726  18719106  19549727  21422291  21659603  22036607  
22681887  25416956  25931565  26496610  
GO:0031593polyubiquitin modification-dependent protein binding-IDA22742833  
GO:0031625ubiquitin protein ligase binding-IPI10908344  18363965  
GO:0042802identical protein binding-IDA25023518  
GO:0043142single-stranded DNA-dependent ATPase activity-IBA21873635  
GO:0044877protein-containing complex binding-IPI25931565  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-NAS10884424  
GO:0006301postreplication repair-IBA21873635  
GO:0006513protein monoubiquitination-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IDA22036607  25023518  25931565  
GO:0009411response to UV-IBA21873635  
GO:0016567protein ubiquitination-TAS-  
GO:0042769DNA damage response, detection of DNA damage-TAS-  
GO:0051865protein autoubiquitination-IDA25023518  
GO:0051984positive regulation of chromosome segregation-IMP25931565  
GO:0060548negative regulation of cell death-IDA22036607  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15632077  22036607  25023518  
GO:0005634nucleus-NAS10884424  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication fork-IDA18363965  
GO:0005737cytoplasm-IEA-  
GO:0005813centrosome-IDA15632077  
GO:0016604nuclear body-IDA-  
GO:0035861site of double-strand break-IDA25931565  
GO:0042405nuclear inclusion body-IDA22036607  
GO:0097505Rad6-Rad18 complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-110314Recognition of DNA damage by PCNA-containing replication complexTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73893DNA Damage BypassTAS
R-HSA-73894DNA RepairTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26683928Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection. (2015 Dec)Rhie AMedicine (Baltimore)