Gene: PSMA7

5688
C6|HEL-S-276|HSPC|RC6-1|XAPC7
proteasome subunit alpha 7
protein-coding
20q13.33
Ensembl:ENSG00000101182 MIM:606607 Vega:OTTHUMG00000032895 UniprotKB:O14818
NG_046998.1
PubMed
CD|OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.050e-2 (AD)  3.938e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00071265chr20:60717158PSMA77.500e-17Smoking27651444
cg12800803chr20:60717299PSMA76.700e-16Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMB60.959
EIF3I0.953
PSMB40.946
PSMB70.945
SRSF90.943
STOML20.943
EIF60.943
HAX10.943
PDAP10.942
CFL10.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.808
OR4F29-0.78
P2RY14-0.286
MTRNR2L6-0.274
MTRNR2L9-0.26
MTRNR2L10-0.239
VNN3-0.203
C8orf74-0.202
CXCR2-0.2
TTLL10-AS1-0.197

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB075582-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDESmall MoleculeExperimentalTarget
DB08515(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of PSMA7 mRNA"15375163
C0194992-nitrofluorene2-nitrofluorene results in increased expression of PSMA7 mRNA15890375
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMA7 mRNA15890375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PSMA7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PSMA7 mRNA15890375
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PSMA7 mRNA16483693
D001280AtrazineAtrazine results in increased expression of PSMA7 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PSMA7 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSMA7 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSMA7 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of PSMA7 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PSMA7 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PSMA7 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of PSMA7 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PSMA7 mRNA18804290
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PSMA7 mRNA20360939
D002994ClofibrateClofibrate results in increased expression of PSMA7 mRNA21318169
D019327Copper SulfateCopper Sulfate results in increased expression of PSMA7 mRNA19264136
D016572CyclosporineCyclosporine results in increased expression of PSMA7 mRNA20106945
D004041Dietary FatsDietary Fats results in decreased expression of PSMA7 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PSMA7 mRNA21318169
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PSMA7 mRNA20360939
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PSMA7 mRNA15890375
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PSMA7 mRNA15890375
D004317DoxorubicinDoxorubicin results in increased metabolism of PSMA7 protein17346995
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMA7 mRNA17942748
D018120FinasterideFinasteride results in increased expression of PSMA7 mRNA24136188
D005485FlutamideFlutamide results in increased expression of PSMA7 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of PSMA7 mRNA19167457
C039281furanfuran results in increased methylation of PSMA7 gene22079235
D005839GentamicinsGentamicins results in increased expression of PSMA7 mRNA22061828
C424943glutamyl-Se-methylselenocysteineglutamyl-Se-methylselenocysteine results in decreased expression of PSMA7 mRNA11306469
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of PSMA7 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PSMA7 mRNA25613284
D048628KetolidesKetolides analog results in decreased expression of PSMA7 mRNA24967691
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PSMA7 mRNA"19264136
D008701MethapyrileneMethapyrilene results in increased expression of PSMA7 mRNA15890375
D008748MethylcholanthreneMethylcholanthrene affects the expression of PSMA7 mRNA18804290
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PSMA7 mRNA"29244179
C051752nefazodonenefazodone results in increased expression of PSMA7 mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of PSMA7 mRNA19167457
C012655nimesulidenimesulide results in increased expression of PSMA7 mRNA24136188
D010100OxygenOxygen deficiency results in decreased expression of PSMA7 protein25937538
D010416PentachlorophenolPentachlorophenol results in increased expression of PSMA7 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of PSMA7 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PSMA7 mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of PSMA7 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PSMA7 mRNA18467677|2131816
C023036perfluorooctanoic acidPPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of PSMA7 mRNA]21318169
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of PSMA7 mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PSMA7 mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PSMA7 mRNA19162173|2131816
D010634PhenobarbitalPhenobarbital results in increased expression of PSMA7 mRNA19162173|2131816
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of PSMA7 mRNA15890375|2248451
C006253pirinixic acidpirinixic acid results in increased expression of PSMA7 mRNA15375163|1830175
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of PSMA7 mRNA]21318169
C006253pirinixic acidpirinixic acid results in increased expression of PSMA7 mRNA15890375|1916217
D010936Plant ExtractsPlant Extracts results in increased expression of PSMA7 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PSMA7 mRNA19162173|2131816
C031280pyrazolepyrazole results in increased expression of PSMA7 mRNA17945193
D015474IsotretinoinIsotretinoin results in decreased expression of PSMA7 mRNA20436886
D012402RotenoneRotenone results in decreased expression of PSMA7 mRNA23186747
D012715Sesame OilSesame Oil results in increased expression of PSMA7 mRNA29191790
D012969Sodium FluorideSodium Fluoride results in decreased expression of PSMA7 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of PSMA7 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSMA7 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMA7 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PSMA7 mRNA25613284
D014212TretinoinTretinoin results in increased expression of PSMA7 mRNA17218384
D017974Uranium CompoundsUranium Compounds results in decreased expression of PSMA7 mRNA19654044
C406224valdecoxibvaldecoxib results in increased expression of PSMA7 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of PSMA7 mRNA21318169

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-IBA21873635  
GO:0004298threonine-type endopeptidase activity-IEA-  
GO:0005515protein binding-IPI11389899  12376572  14733938  15225636  16251969  17948026  
19416853  21900206  21988832  25599644  29568061  
GO:0042802identical protein binding-IPI15225636  17948026  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0010498proteasomal protein catabolic process-IBA21873635  
GO:0010499proteasomal ubiquitin-independent protein catabolic process-IBA21873635  
GO:0016032viral process-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000502proteasome complex-IDA17323924  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005839proteasome core complex-IBA21873635  
GO:0005839proteasome core complex-ISS-  
GO:0019773proteasome core complex, alpha-subunit complex-IBA21873635  
GO:0019773proteasome core complex, alpha-subunit complex-ISS-  
GO:0070062extracellular exosome-HDA20458337  23533145  
GO:0098794postsynapse-IBA21873635  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
hsa03050Proteasome
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1169091Activation of NF-kappaB in B cellsTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1236974ER-Phagosome pathwayIEA
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1236975Antigen processing-Cross presentationIEA
R-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)TAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-169911Regulation of ApoptosisIEA
R-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/CTAS
R-HSA-174113SCF-beta-TrCP mediated degradation of Emi1TAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174154APC/C:Cdc20 mediated degradation of SecurinTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-180534Vpu mediated degradation of CD4TAS
R-HSA-180585Vif-mediated degradation of APOBEC3GTAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-211733Regulation of activated PAK-2p34 by proteasome mediated degradationIEA
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2871837FCERI mediated NF-kB activationTAS
R-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1TAS
R-HSA-350562Regulation of ornithine decarboxylase (ODC)TAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-422475Axon guidanceIEA
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-4608870Asymmetric localization of PCP proteinsTAS
R-HSA-4641257Degradation of AXINTAS
R-HSA-4641258Degradation of DVLTAS
R-HSA-5357801Programmed Cell DeathIEA
R-HSA-5358346Hedgehog ligand biogenesisTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERADTAS
R-HSA-5387390Hh mutants abrogate ligand secretionTAS
R-HSA-5607761Dectin-1 mediated noncanonical NF-kB signalingTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5610780Degradation of GLI1 by the proteasomeTAS
R-HSA-5610783Degradation of GLI2 by the proteasomeIEA
R-HSA-5610785GLI3 is processed to GLI3R by the proteasomeTAS
R-HSA-5610787Hedgehog 'off' stateIEA
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5676590NIK-->noncanonical NF-kB signalingTAS
R-HSA-5678895Defective CFTR causes cystic fibrosisTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-68827CDT1 association with the CDC6:ORC:origin complexTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69229Ubiquitin-dependent degradation of Cyclin D1TAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69541Stabilization of p53TAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25ATAS
R-HSA-69610p53-Independent DNA Damage ResponseTAS
R-HSA-69613p53-Independent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75815Ubiquitin-dependent degradation of Cyclin DTAS
R-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointTAS
R-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosisTAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8939902Regulation of RUNX2 expression and activityTAS
R-HSA-8941858Regulation of RUNX3 expression and activityTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-8951664NeddylationTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal