Gene: AGPAT3

56894
LPAAT-GAMMA1|LPAAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
protein-coding
21q22.3
Ensembl:ENSG00000160216 MIM:614794 Vega:OTTHUMG00000086892 UniprotKB:Q9NRZ7
NC_000021.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.256e-1 (AD)  7.454e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADD10.926
CDC42BPB0.921
ACO20.916
FAM168A0.915
OSBPL20.912
RAB1B0.908
OGDH0.905
GABBR10.905
TOM1L20.904
APLP20.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.769
OR4F29-0.745
SLAMF6-0.363
IL24-0.356
DPPA4-0.349
XCL2-0.34
CD48-0.34
GZMK-0.34
C2orf83-0.338
MTRNR2L6-0.338

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AGPAT3 mRNA"27291303
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AGPAT3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGPAT3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGPAT3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGPAT3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGPAT3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of AGPAT3 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AGPAT3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of AGPAT3 gene28458013
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AGPAT3 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of AGPAT3 mRNA24449571
D001104ArbutinArbutin results in decreased expression of AGPAT3 mRNA17103032
D001151ArsenicArsenic affects the methylation of AGPAT3 gene25304211
D001280AtrazineAtrazine results in increased expression of AGPAT3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGPAT3 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to AGPAT3 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGPAT3 mRNA21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AGPAT3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGPAT3 mRNA"20018196
D004958EstradiolEstradiol results in increased expression of AGPAT3 mRNA19693291
C006780bisphenol Abisphenol A affects the expression of AGPAT3 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of AGPAT3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AGPAT3 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of AGPAT3 promoter22457795
D002392CatechinCatechin inhibits the reaction [Dietary Fats results in increased expression of AGPAT3 mRNA]23365609
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of AGPAT3 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of AGPAT3 mRNA17553155
D019327Copper SulfateCopper Sulfate results in decreased expression of AGPAT3 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of AGPAT3 mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of AGPAT3 mRNA21072851
D016572CyclosporineCyclosporine results in decreased expression of AGPAT3 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased methylation of AGPAT3 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AGPAT3 mRNA23640034
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of AGPAT3 mRNA23428407
D004041Dietary FatsCatechin inhibits the reaction [Dietary Fats results in increased expression of AGPAT3 mRNA]23365609
D004041Dietary FatsDietary Fats results in increased expression of AGPAT3 mRNA23365609
D004041Dietary FatsPlant Extracts inhibits the reaction [Dietary Fats results in increased expression of AGPAT3 mRNA]23365609
D004237DiuronDiuron results in decreased expression of AGPAT3 mRNA21551480
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of AGPAT3 mRNA23649840
C436526EUK-189EUK-189 inhibits the reaction [SOD2 gene mutant form results in increased expression of AGPAT3 mRNA]15964507
D018120FinasterideFinasteride results in increased expression of AGPAT3 mRNA24136188
D005485FlutamideFlutamide results in increased expression of AGPAT3 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of AGPAT3 mRNA23649840
D005839GentamicinsGentamicins results in decreased expression of AGPAT3 mRNA22061828
C029424hydrazinehydrazine results in increased expression of AGPAT3 mRNA15282401
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of AGPAT3 mRNA23428407
D007538IsoniazidIsoniazid results in increased expression of AGPAT3 mRNA28619387
D007538Isoniazidsilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]28619387
D007538Isoniazid[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA28619387
C045463leflunomideleflunomide results in increased expression of AGPAT3 mRNA24136188
D008727MethotrexateMethotrexate results in increased expression of AGPAT3 mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AGPAT3 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AGPAT3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AGPAT3 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of AGPAT3 mRNA25583101
D009532NickelNickel results in increased expression of AGPAT3 mRNA24084258
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AGPAT3 mRNA21723365
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGPAT3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AGPAT3 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of AGPAT3 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AGPAT3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of AGPAT3 mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of AGPAT3 mRNA]17950772
D010936Plant ExtractsPlant Extracts results in increased expression of AGPAT3 mRNA23557933
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dietary Fats results in increased expression of AGPAT3 mRNA]23365609
D015474IsotretinoinIsotretinoin results in decreased expression of AGPAT3 mRNA20436886
C440975silybinsilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]28619387
C009277sodium arsenatesodium arsenate results in decreased expression of AGPAT3 mRNA23922661
D012999SomanSoman results in increased expression of AGPAT3 mRNA19281266
D013739TestosteroneTestosterone results in increased expression of AGPAT3 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AGPAT3 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AGPAT3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGPAT3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AGPAT3 mRNA21215274|2623252
C483909torcetrapibtorcetrapib results in increased expression of AGPAT3 mRNA23228038
D014112ToxapheneToxaphene results in increased expression of AGPAT3 mRNA23153324
D014212TretinoinTretinoin results in increased expression of AGPAT3 mRNA21934132
C011559tributyltintributyltin results in increased expression of AGPAT3 mRNA23428407
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGPAT3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of AGPAT3 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of AGPAT3 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of AGPAT3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of AGPAT3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of AGPAT3 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AGPAT3 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of AGPAT3 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of AGPAT3 mRNA20044591
D015215Zidovudinesilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]28619387
D015215Zidovudine[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA28619387
D015215ZidovudineZidovudine results in increased expression of AGPAT3 mRNA28619387
D015034Zinc OxideZinc Oxide affects the expression of AGPAT3 mRNA28648595
D019287Zinc SulfateZinc Sulfate results in increased expression of AGPAT3 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-IBA21873635  
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-NAS15367102  
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0016746transferase activity, transferring acyl groups-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006644phospholipid metabolic process-IBA21873635  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0008654phospholipid biosynthetic process-NAS15367102  
GO:0016024CDP-diacylglycerol biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005635nuclear envelope-IEA-  
GO:0005783endoplasmic reticulum-HDA16780588  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-HDA16780588  
GO:0012505endomembrane system-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811436COPI-independent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28575117Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma. (2017)Miller MAPLoS One