Gene info: ID 5690

Gene: PSMB2

GENE ID: 5690

Synonyms: HC7-I

Description: proteasome subunit beta 2

Gene type: protein-coding

Location: 1p34.3

dbXrefs: Ensembl:ENSG00000126067 MIM:602175 Vega:OTTHUMG00000004169 UniprotKB:P49721

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.292e-1 (AD) 3.959e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAB1A	0.957
NAA20	0.956
CDC42	0.955
CDC123	0.952
HNRNPH2	0.952
UBE2V1	0.952
PSMC2	0.951
SLC25A3	0.95
VDAC1	0.95
OCIAD1	0.95

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.728
OR4F29	-0.686
MTRNR2L6	-0.368
MTRNR2L9	-0.367
MTRNR2L10	-0.336
MTRNR2L2	-0.276
TTLL10	-0.276
CSAG1	-0.275
MTRNR2L8	-0.262
CXCR2	-0.258

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB08515	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE	Small Molecule		Experimental	Target
DB08889	Carfilzomib	Small Molecule	868540-17-4	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of PSMB2 mRNA"	15375163
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PSMB2 mRNA"	23962555
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PSMB2 mRNA"	19114083
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB2 mRNA"	15215175
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PSMB2 protein	26194647
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of PSMB2 mRNA"	17292976
C017906	3-dinitrobenzene	3-dinitrobenzene affects the expression of PSMB2 mRNA	16988215
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of PSMB2 protein	24140754
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of PSMB2 mRNA	24140754
D000082	Acetaminophen	Acetaminophen results in decreased expression of PSMB2 mRNA	21420995
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PSMB2 mRNA	16483693
D001152	Arsenicals	Arsenicals results in increased methylation of PSMB2 promoter	26039340
D001280	Atrazine	Atrazine results in increased expression of PSMB2 mRNA	18522720
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PSMB2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PSMB2 mRNA	21839799
D004958	Estradiol	Estradiol affects the expression of PSMB2 mRNA	15598610
D001622	Betaine	Betaine inhibits the reaction [Copper deficiency affects the expression of PSMB2 protein]	25150618
C006780	bisphenol A	bisphenol A affects the expression of PSMB2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of PSMB2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PSMB2 gene	28505145
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PSMB2 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PSMB2 protein	24386269
D003300	Copper	Betaine inhibits the reaction [Copper deficiency affects the expression of PSMB2 protein]	25150618
D003300	Copper	Copper deficiency affects the expression of PSMB2 protein	25150618
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PSMB2 mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of PSMB2 mRNA	17211630
D016572	Cyclosporine	Cyclosporine results in decreased expression of PSMB2 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of PSMB2 mRNA	20106945\|2556210
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PSMB2 mRNA]	27941970
D016190	Carboplatin	Carboplatin results in increased expression of PSMB2 mRNA	18172885
D003976	Diazinon	Diazinon results in increased methylation of PSMB2 gene	22964155
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of PSMB2 mRNA	21318169
D004147	Dioxins	Dioxins affects the expression of PSMB2 mRNA	20463971
D004317	Doxorubicin	Doxorubicin results in increased metabolism of PSMB2 protein	17346995
D004317	Doxorubicin	Doxorubicin results in decreased expression of PSMB2 mRNA	27155237
C561722	EGFR tyrosine kinase inhibitor 324674	EGFR tyrosine kinase inhibitor 324674 inhibits the reaction [EGF protein results in increased expression of PSMB2 protein]	24627483
D000431	Ethanol	Ethanol affects the expression of PSMB2 mRNA	24355176
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PSMB2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PSMB2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMB2 mRNA	17942748
D011345	Fenofibrate	Fenofibrate results in increased expression of PSMB2 mRNA	21318169
D011345	Fenofibrate	PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMB2 mRNA]	21318169
D005419	Flavonoids	Flavonoids results in decreased expression of PSMB2 mRNA	18035473
D005485	Flutamide	Flutamide results in decreased expression of PSMB2 mRNA	21126777
D005485	Flutamide	Flutamide results in increased expression of PSMB2 mRNA	24136188
D005839	Gentamicins	Gentamicins results in increased expression of PSMB2 mRNA	22061828
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of PSMB2 mRNA	22634610
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of PSMB2 mRNA	17183730
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PSMB2 mRNA	25613284
C410337	K 7174	K 7174 results in decreased expression of PSMB2 mRNA	24086573
D007854	Lead	Lead results in decreased expression of PSMB2 mRNA	19921347
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of PSMB2 mRNA	22185406
D008727	Methotrexate	Methotrexate results in decreased expression of PSMB2 mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PSMB2 mRNA	23103053
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PSMB2 mRNA	26011545
C063855	microcystin RR	microcystin RR results in decreased expression of PSMB2 protein	19111056
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PSMB2 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PSMB2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PSMB2 mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of PSMB2 mRNA	24136188
D009354	Neodymium	Neodymium results in decreased expression of PSMB2 protein	20332019
C012655	nimesulide	nimesulide results in increased expression of PSMB2 mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of PSMB2 mRNA	17616710
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PSMB2 mRNA"	12756304
D016627	Oxidopamine	Oxidopamine results in increased expression of PSMB2 mRNA	12486162
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PSMB2 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of PSMB2 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of PSMB2 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PSMB2 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PSMB2 mRNA]	17655762
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of PSMB2 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of PSMB2 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PSMB2 mRNA]	17655762
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of PSMB2 mRNA	24642059
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of PSMB2 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of PSMB2 mRNA	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of PSMB2 mRNA	19429403
D010634	Phenobarbital	Phenobarbital results in increased expression of PSMB2 mRNA	19162173\|2131816
D010695	Phlorhizin	Phlorhizin results in decreased expression of PSMB2 mRNA	22538082
C006253	pirinixic acid	pirinixic acid results in increased expression of PSMB2 mRNA	18301758\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of PSMB2 mRNA	19162173\|2131816
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of PSMB2 mRNA	19162173\|2131816
C031280	pyrazole	pyrazole results in increased expression of PSMB2 mRNA	17945193
D012402	Rotenone	Rotenone results in decreased expression of PSMB2 mRNA	23186747
D012906	Smoke	Smoke results in decreased expression of PSMB2 mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in decreased expression of PSMB2 mRNA	23922661
C017947	sodium arsenite	sodium arsenite results in increased expression of PSMB2 mRNA	28595984
C517409	stattic	stattic results in decreased expression of PSMB2 mRNA	24627483
C517409	stattic	stattic results in decreased expression of PSMB2 protein	24627483
D013629	Tamoxifen	Tamoxifen affects the expression of PSMB2 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PSMB2 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PSMB2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMB2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PSMB2 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PSMB2 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PSMB2 mRNA	25613284
D013806	Theophylline	Theophylline affects the expression of PSMB2 mRNA	16988215
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PSMB2 mRNA	22363418
C082097	tocotrienol, delta	"tocotrienol, delta results in decreased expression of PSMB2 mRNA"	22185406
D014212	Tretinoin	Tretinoin results in increased expression of PSMB2 mRNA	17218384
D014241	Trichloroethylene	Trichloroethylene affects the expression of PSMB2 mRNA	21135412
C406224	valdecoxib	valdecoxib results in increased expression of PSMB2 mRNA	24136188
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of PSMB2 mRNA	17183730
D014635	Valproic Acid	Valproic Acid results in increased expression of PSMB2 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased methylation of PSMB2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PSMB2 mRNA	21318169
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of PSMB2 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of PSMB2 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PSMB2 mRNA]	17655762
D014810	Vitamin E	Vitamin E results in increased expression of PSMB2 mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of PSMB2 protein	17593366\|2054356
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of PSMB2 mRNA	12756304

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004175	endopeptidase activity	-	IBA	21873635
GO:0004298	threonine-type endopeptidase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	12376572 14733938 17948026 25416956 25599644 29568061

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0010243	response to organonitrogen compound	-	IEA	-
GO:0010498	proteasomal protein catabolic process	-	IBA	21873635
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	-	IBA	21873635
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0016032	viral process	-	IEA	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IBA	21873635
GO:0043687	post-translational protein modification	-	TAS	-
GO:0051603	proteolysis involved in cellular protein catabolic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000502	proteasome complex	-	IDA	17323924
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0005839	proteasome core complex	-	IBA	21873635
GO:0005839	proteasome core complex	-	ISS	-
GO:0016020	membrane	-	HDA	19946888
GO:0019774	proteasome core complex, beta-subunit complex	-	ISS	-
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145

KEGG ID	KEGG Term
hsa03050	Proteasome

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	IEA
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	TAS
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	TAS
R-HSA-1236974	ER-Phagosome pathway	IEA
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1236975	Antigen processing-Cross presentation	IEA
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-169911	Regulation of Apoptosis	IEA
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	TAS
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	TAS
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	TAS
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	TAS
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	TAS
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	TAS
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	TAS
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	TAS
R-HSA-180534	Vpu mediated degradation of CD4	TAS
R-HSA-180585	Vif-mediated degradation of APOBEC3G	TAS
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	IEA
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2262749	Cellular response to hypoxia	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	TAS
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	TAS
R-HSA-351202	Metabolism of polyamines	TAS
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382556	ABC-family proteins mediated transport	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-4086400	PCP/CE pathway	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	TAS
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453276	Regulation of mitotic cell cycle	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-4608870	Asymmetric localization of PCP proteins	TAS
R-HSA-4641257	Degradation of AXIN	TAS
R-HSA-4641258	Degradation of DVL	TAS
R-HSA-5357801	Programmed Cell Death	IEA
R-HSA-5358346	Hedgehog ligand biogenesis	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5358351	Signaling by Hedgehog	IEA
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	TAS
R-HSA-5387390	Hh mutants abrogate ligand secretion	TAS
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5610780	Degradation of GLI1 by the proteasome	TAS
R-HSA-5610783	Degradation of GLI2 by the proteasome	IEA
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	TAS
R-HSA-5610787	Hedgehog 'off' state	IEA
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5632684	Hedgehog 'on' state	TAS
R-HSA-5658442	Regulation of RAS by GAPs	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	TAS
R-HSA-5678895	Defective CFTR causes cystic fibrosis	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689603	UCH proteinases	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	TAS
R-HSA-68867	Assembly of the pre-replicative complex	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-68949	Orc1 removal from chromatin	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	TAS
R-HSA-69052	Switching of origins to a post-replicative state	TAS
R-HSA-69202	Cyclin E associated events during G1/S transition	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69541	Stabilization of p53	TAS
R-HSA-69563	p53-Dependent G1 DNA Damage Response	TAS
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	TAS
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	TAS
R-HSA-69610	p53-Independent DNA Damage Response	TAS
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	TAS
R-HSA-69615	G1/S DNA Damage Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	TAS
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	TAS
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA
R-HSA-8939902	Regulation of RUNX2 expression and activity	TAS
R-HSA-8941858	Regulation of RUNX3 expression and activity	TAS
R-HSA-8948751	Regulation of PTEN stability and activity	TAS
R-HSA-8951664	Neddylation	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	IEA
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18671841	PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells. (2008 Jul 31)	Kriegova E	BMC Mol Biol