Gene: OTOR

56914
FDP|MIAL1
otoraplin
protein-coding
20p12.1
Ensembl:ENSG00000125879 MIM:606067 Vega:OTTHUMG00000031931 UniprotKB:Q9NRC9
NC_000020.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.768e-1 (AD)  3.695e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC170.836
OR7C20.822
DEFB1150.803
CNGA20.797
HTR3D0.79
TAAR10.781
CPN20.772
OPN1MW20.77
PLA2G2E0.769
ODF40.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF253-0.206
OMG-0.196
OTC-0.192
DCUN1D1-0.189
PEX11A-0.187
MDH1B-0.183
CDH20-0.182
ZNF514-0.179
MRPL50-0.178
LRRC34-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of OTOR mRNA25181051
D003300CopperCopper deficiency results in increased expression of OTOR mRNA26033743
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of OTOR mRNA21266533
D019422Dietary SucroseDietary Sucrose results in increased expression of OTOR mRNA26033743
D011441PropylthiouracilPropylthiouracil results in increased expression of OTOR mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of OTOR mRNA20106945|2163298
D013853ThioacetamideThioacetamide results in increased expression of OTOR mRNA23411599
D014212TretinoinTretinoin results in decreased expression of OTOR mRNA23724009
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OTOR gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001502cartilage condensation-IEA-  
GO:0007605sensory perception of sound-TAS10873378  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665419Prenatal smoke exposure: effects on infant auditory system and placental gene expression. (2013 Jul-Aug)Katbamna BNeurotoxicol Teratol