Gene: PAK6

56924
PAK5
p21 (RAC1) activated kinase 6
protein-coding
15q15.1
Ensembl:ENSG00000137843 MIM:608110 Vega:OTTHUMG00000129921 UniprotKB:Q9NQU5
NG_033169.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.719e-1 (AD)  8.086e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLGAP30.921
SYNPO0.921
MGAT5B0.921
SPTBN20.918
CELF30.912
AGAP20.911
NPTXR0.909
JPH40.908
SEPT50.908
FBXO410.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SGMS2-0.55
ANXA13-0.537
SNHG18-0.53
TGFB3-0.518
VRK2-0.515
CLEC2B-0.515
DTHD1-0.501
RAI14-0.499
LAYN-0.498
BAZ1A-0.497

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl affects the expression of PAK6 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of PAK6 mRNA"23829299
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PAK6 protein modified form]"28751236
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of PAK6 mRNA"22745752
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PAK6 mRNA17562736
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PAK6 mRNA22129741
D020106AcrylamideAcrylamide results in increased expression of PAK6 mRNA28959563
C016601afimoxifenePAK6 results in decreased susceptibility to afimoxifene21233418
C547126AZM551248AZM551248 results in decreased expression of PAK6 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PAK6 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PAK6 mRNA23735875
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PAK6 protein modified form]28751236
C006780bisphenol Abisphenol A results in increased methylation of PAK6 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of PAK6 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PAK6 mRNA25181051
D003042CocaineCocaine results in decreased expression of PAK6 mRNA18000554
D003300CopperCopper deficiency results in increased expression of PAK6 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of PAK6 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of PAK6 mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of PAK6 promoter27989131
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PAK6 mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of PAK6 mRNA16002434
C118739entinostatentinostat results in increased expression of PAK6 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
D018120FinasterideFinasteride results in decreased expression of PAK6 mRNA24136188
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PAK6 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PAK6 mRNA25613284
D007854LeadLead affects the expression of PAK6 mRNA28903495
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
D008727MethotrexateMethotrexate results in increased expression of PAK6 mRNA21678067
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PAK6 mRNA23519560
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PAK6 mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PAK6 mRNA"20188158|2625132
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of PAK6 mRNA20886546
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PAK6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PAK6 mRNA"25554681
D052638Particulate MatterParticulate Matter results in decreased expression of PAK6 mRNA24769257
C410127PCB 180PCB 180 results in decreased expression of PAK6 mRNA23829299
D010634PhenobarbitalPhenobarbital affects the expression of PAK6 mRNA19136022
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PAK6 mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of PAK6 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of PAK6 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of PAK6 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PAK6 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of PAK6 mRNA24780913
D012906SmokeSmoke results in decreased expression of PAK6 mRNA21095227
D053260SootSoot results in increased expression of PAK6 mRNA26551751
D013467SulindacSulindac results in decreased expression of PAK6 mRNA24136188
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of PAK6 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PAK6 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PAK6 mRNA23519560
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PAK6 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of PAK6 mRNA22659510
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAK6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PAK6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PAK6 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of PAK6 gene29154799
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of PAK6 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0005515protein binding-IPI24510904  24947832  25416956  
GO:0005524ATP binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO:0048365Rac GTPase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-TAS20070256  
GO:0006915apoptotic process-TAS20070256  
GO:0007010cytoskeleton organization-TAS20070256  
GO:0007266Rho protein signal transduction-IBA21873635  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0016477cell migration-IBA21873635  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0030054cell junction-IDA-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04660T cell receptor signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-428540Activation of RAC1IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28816646Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis. (2017 Aug)Solanki HSOMICS
27542207Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells. (2016 Sep 20)Raja ROncotarget