Gene: LXN

56925
ECI|TCI
latexin
protein-coding
3q25.32
Ensembl:ENSG00000079257 MIM:609305 Vega:OTTHUMG00000158807 UniprotKB:Q9BS40
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
5.691e-2 (AD)  8.343e-1 (ND)   (Frontal_Cortex)
8.267e-2 (AD)  4.871e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGAP180.632
CAV20.586
PGR0.582
IKBIP0.58
LMO20.577
PROCR0.574
CLEC14A0.573
FLI10.569
PALMD0.568
CAV10.551

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEZF2-0.362
NEUROG2-0.341
SORCS2-0.292
NXPH3-0.292
YBX2-0.289
LCNL1-0.283
MOXD1-0.277
RAB41-0.273
RHCG-0.271
CABLES1-0.271

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of LXN mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LXN mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of LXN mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of LXN mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LXN mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of LXN mRNA21757418
C000188alachloralachlor results in increased expression of LXN mRNA12419858
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LXN mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of LXN mRNA"18687144
D001205Ascorbic AcidAscorbic Acid results in increased expression of LXN mRNA22139585
D001205Ascorbic AcidAscorbic Acid results in increased expression of LXN protein22139585
D001379AzathioprineAzathioprine results in increased expression of LXN mRNA19192274
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LXN mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LXN mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of LXN mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LXN mRNA19770486|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of LXN mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LXN mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LXN mRNA]25566086
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of LXN mRNA]24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LXN mRNA19619570
D004958EstradiolEstradiol results in decreased expression of LXN mRNA19619570|2118537
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of LXN mRNA17404688
C004541biochanin Abiochanin A results in increased expression of LXN mRNA12111696
C006780bisphenol Abisphenol A results in increased expression of LXN mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of LXN mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of LXN protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LXN mRNA16997883
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LXN mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LXN gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of LXN mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of LXN mRNA19770486
C014347decitabinedecitabine affects the expression of LXN mRNA17145863
D013759DronabinolDronabinol results in increased expression of LXN protein18584336
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LXN mRNA16997883
D003907DexamethasoneDexamethasone results in decreased expression of LXN mRNA25047013
D004008DiclofenacDiclofenac results in increased expression of LXN mRNA19192274
D004041Dietary FatsDietary Fats results in increased expression of LXN mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LXN mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of LXN mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of LXN mRNA21592394
D004237DiuronDiuron results in increased expression of LXN mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LXN mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LXN mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of LXN mRNA15954086
D005047EtoposideLXN protein results in increased susceptibility to Etoposide25341047
D005419FlavonoidsFlavonoids results in decreased expression of LXN mRNA18035473
D005472FluorouracilLXN protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in increased expression of LXN mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LXN gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of LXN mRNA23649840
C039281furanfuran results in increased expression of LXN mRNA27387713
D019833GenisteinGenistein results in decreased expression of LXN mRNA23019147
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of LXN mRNA22634610
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of LXN mRNA19192274
D017313FenretinideFenretinide results in increased expression of LXN mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of LXN mRNA21396975
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LXN mRNA16997883
D007657Ketone BodiesKetone Bodies results in increased expression of LXN mRNA15469884
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LXN mRNA"24972896
D008154LucanthoneLucanthone results in increased expression of LXN mRNA21148553
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LXN gene20938992
D008727MethotrexateMethotrexate results in increased expression of LXN mRNA19192274
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LXN mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LXN mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LXN mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of LXN promoter"26251327
D015735MifepristoneMifepristone results in increased expression of LXN mRNA17584828
C500085muraglitazarmuraglitazar results in decreased expression of LXN mRNA21515302
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of LXN mRNA19812364
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of LXN mRNA17616710
C558013NSC 689534NSC 689534 results in increased expression of LXN mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in decreased expression of LXN mRNA"18204070
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LXN mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of LXN mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of LXN mRNA18042831
D010634PhenobarbitalPhenobarbital results in increased expression of LXN mRNA19162173
D010894PiroxicamPiroxicam results in increased expression of LXN mRNA19192274
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LXN mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LXN mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of LXN mRNA23012394
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of LXN mRNA17404688
C059514resveratrolresveratrol results in increased expression of LXN protein25505154
C089730rosiglitazonerosiglitazone results in decreased expression of LXN mRNA21515302
C009277sodium arsenatesodium arsenate results in increased expression of LXN mRNA23922661
D012969Sodium FluorideSodium Fluoride results in decreased expression of LXN protein28918527
C501413tesaglitazartesaglitazar results in decreased expression of LXN mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of LXN mRNA21592394
D013739TestosteroneTestosterone results in increased expression of LXN mRNA21592394
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LXN mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LXN mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LXN mRNA17517823
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LXN mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LXN mRNA22298810
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LXN mRNA25729387
D019772TopotecanTopotecan results in increased expression of LXN mRNA25729387
D014212TretinoinTretinoin results in increased expression of LXN mRNA23830798
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LXN mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of LXN mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of LXN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LXN mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of LXN gene29154799
C025643vinclozolinvinclozolin results in decreased expression of LXN mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of LXN mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  25416956  
GO:0008191metalloendopeptidase inhibitor activity-IEA-  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IEA-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0050965detection of temperature stimulus involved in sensory perception of pain-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26317789LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation. (2015 Sep 22)Lee CHOncotarget