Gene: ARNTL2

56938
BMAL2|CLIF|MOP9|PASD9|bHLHe6
aryl hydrocarbon receptor nuclear translocator like 2
protein-coding
12p11.23
Ensembl:ENSG00000029153 MIM:614517 Vega:OTTHUMG00000169257 UniprotKB:Q8WYA1
NG_030359.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.109e-1 (AD)  7.081e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCP11L10.901
ARHGAP200.899
RGS7BP0.885
PITPNB0.883
STXBP50.879
MKL20.878
PPM1E0.878
C1QL30.876
PCDHAC20.875
HIVEP20.872

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STON2-0.532
AKR1C3-0.525
S100A1-0.519
IMPA2-0.512
HVCN1-0.507
OLAH-0.501
ROM1-0.5
EYA2-0.498
ACOX2-0.495
FXYD3-0.489

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARNTL2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARNTL2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARNTL2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARNTL2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARNTL2 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of ARNTL2 mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ARNTL2 mRNA"28973690
D000082AcetaminophenAcetaminophen results in decreased expression of ARNTL2 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of ARNTL2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ARNTL2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARNTL2 mRNA19770486
D001507BeclomethasoneBeclomethasone results in increased expression of ARNTL2 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARNTL2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARNTL2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARNTL2 mRNA23735875|2590861
C006780bisphenol Abisphenol A affects the expression of ARNTL2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ARNTL2 mRNA20678512|2927551
C006780bisphenol Abisphenol A affects the methylation of ARNTL2 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of ARNTL2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of ARNTL2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ARNTL2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ARNTL2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of ARNTL2 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARNTL2 mRNA19320972
C060728cobalt oxidecobalt oxide analog results in increased expression of ARNTL2 mRNA24821434
D003471CuprizoneCuprizone results in decreased expression of ARNTL2 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of ARNTL2 mRNA20106945|2556210
D000069439DasatinibDasatinib results in decreased expression of ARNTL2 mRNA20579391
C016366dibenzothiophenedibenzothiophene results in increased expression of ARNTL2 mRNA23656968
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of ARNTL2 mRNA21791302
D002945CisplatinCisplatin results in increased expression of ARNTL2 mRNA27594783
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ARNTL2 mRNA24535843
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ARNTL2 mRNA"22485181
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of ARNTL2 mRNA"27840820
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ARNTL2 mRNA20227414
D005557FormaldehydeFormaldehyde results in decreased expression of ARNTL2 mRNA23649840
C057444fumaronitrileARNTL2 gene SNP affects the susceptibility to fumaronitrile25622337
C004312glycidolglycidol results in decreased expression of ARNTL2 mRNA24915197
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARNTL2 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ARNTL2 mRNA25613284
D008627Mercuric ChlorideMercuric Chloride affects the expression of ARNTL2 mRNA20353558
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ARNTL2 mRNA23649840
C500085muraglitazarmuraglitazar results in decreased expression of ARNTL2 mRNA21515302
D009532NickelNickel results in increased expression of ARNTL2 mRNA24768652|2558310
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of ARNTL2 mRNA21791302
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARNTL2 mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARNTL2 mRNA19710929
D017035PravastatinPravastatin results in increased expression of ARNTL2 mRNA27225895
D017035PravastatinPravastatin affects the expression of ARNTL2 mRNA27225895
D011794QuercetinQuercetin results in increased expression of ARNTL2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ARNTL2 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of ARNTL2 mRNA24570342
C017947sodium arsenitesodium arsenite results in increased methylation of ARNTL2 gene24570342
D012969Sodium FluorideSodium Fluoride results in increased expression of ARNTL2 mRNA27257137
C075117squalestatin 1squalestatin 1 affects the expression of ARNTL2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of ARNTL2 mRNA27225895
D014284TriiodothyronineTriiodothyronine results in decreased expression of ARNTL2 mRNA22281776
C501413tesaglitazartesaglitazar results in decreased expression of ARNTL2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARNTL2 mRNA21570461|2405805
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARNTL2 mRNA25613284
C012589trichostatin Atrichostatin A results in decreased expression of ARNTL2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of ARNTL2 mRNA21515302
D014635Valproic AcidValproic Acid results in increased expression of ARNTL2 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ARNTL2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15147242  
GO:0003700DNA-binding transcription factor activity-IDA12055078  
GO:0003700DNA-binding transcription factor activity-NAS11018023  
GO:0046983protein dimerization activity-IEA-  
GO:0070888E-box binding-IDA12738229  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS11018023  
GO:0006357regulation of transcription by RNA polymerase II-IDA12055078  
GO:0007623circadian rhythm-IDA10864977  
GO:0009649entrainment of circadian clock-NAS11018023  
GO:0042753positive regulation of circadian rhythm-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA12738229  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15147242  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12055078  
GO:0005634nucleus-NAS11018023  
GO:0005667transcription factor complex-IEA-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionTAS
R-HSA-400253Circadian ClockTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25677407Clock genes in human alcohol abuse and comorbid conditions. (2015 Jun)Partonen TAlcohol
20554694Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (2010 Jul-Aug)Kovanen LAlcohol Alcohol
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One