Gene: DUSP22

56940
JKAP|JSP-1|JSP1|LMW-DSP2|LMWDSP2|MKP-x|MKPX|VHX
dual specificity phosphatase 22
protein-coding
6p25.3
Ensembl:ENSG00000112679 MIM:616778 Vega:OTTHUMG00000014113 UniprotKB:Q9NRW4
NC_000006.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.012e-1 (AD)  6.996e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GDE10.933
OPTN0.925
ZDHHC30.915
CAB390.912
PAFAH1B20.91
ARMCX30.91
MKRN10.908
MSL10.903
SERINC30.903
MAPRE20.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.652
OR4F29-0.645
MTRNR2L10-0.337
MTRNR2L6-0.334
PON3-0.303
KCNK5-0.296
GLI3-0.29
P2RY14-0.29
MTRNR2L9-0.286
LRAT-0.271

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DUSP22 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of DUSP22 mRNA"18648102
C0293704-toluidine4-toluidine results in increased expression of DUSP22 mRNA27638505
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of DUSP22 mRNA"17331233
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of DUSP22 promoter22796920
D001564Benzo(a)pyrene[Benzo(a)pyrene results in decreased methylation of DUSP22 promoter] which results in increased expression of DUSP22 mRNA22796920|2279692
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DUSP22 mRNA22796920
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DUSP22 mRNA]22228805
C004656chloroacetaldehydechloroacetaldehyde affects the expression of DUSP22 mRNA25596134
C059262cidofovircidofovir results in increased expression of DUSP22 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of DUSP22 mRNA25596134
D003375CoumestrolCoumestrol results in decreased expression of DUSP22 mRNA19167446
C014347decitabinedecitabine affects the expression of DUSP22 mRNA23300844
D002945CisplatinCisplatin affects the expression of DUSP22 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of DUSP22 mRNA27392435
D002945CisplatinCisplatin results in increased expression of DUSP22 mRNA25596134|2739243
D002945CisplatinCisplatin results in increased expression of DUSP22 mRNA21151649
D004026DieldrinDieldrin affects the expression of DUSP22 mRNA22546817
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of DUSP22 mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DUSP22 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DUSP22 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DUSP22 mRNA23649840
D018120FinasterideFinasteride results in increased expression of DUSP22 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of DUSP22 mRNA22061828
D007052IbuprofenIbuprofen results in increased expression of DUSP22 mRNA25596134
D007069IfosfamideIfosfamide results in increased expression of DUSP22 mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DUSP22 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of DUSP22 mRNA27392435
C544151jinfukangjinfukang results in increased expression of DUSP22 mRNA27392435
D007649KetamineKetamine results in increased expression of DUSP22 mRNA20080153
D008687MetforminMetformin results in decreased expression of DUSP22 mRNA25596134
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DUSP22 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DUSP22 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of DUSP22 mRNA22714537
D010100OxygenOxygen deficiency results in decreased expression of DUSP22 mRNA25596134
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DUSP22 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of DUSP22 mRNA18301758|2381119
D011374ProgesteroneProgesterone results in increased expression of DUSP22 mRNA18037150
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DUSP22 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DUSP22 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DUSP22 mRNA25613284
D014635Valproic AcidValproic Acid results in decreased expression of DUSP22 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IEA-  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP16636663  
GO:0000188inactivation of MAPK activity-TAS9205128  
GO:0002710negative regulation of T cell mediated immunity-IEA-  
GO:0006470protein dephosphorylation-TAS9205128  
GO:0006915apoptotic process-TAS9205128  
GO:0007179transforming growth factor beta receptor signaling pathway-IBA21873635  
GO:0007275multicellular organism development-TAS9205128  
GO:0008283cell proliferation-TAS9205128  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0046330positive regulation of JNK cascade-IBA21873635  
GO:0050860negative regulation of T cell receptor signaling pathway-IEA-  
GO:0050868negative regulation of T cell activation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23535363Interferon-gamma promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma. (2013 Jun)Ouyang BToxicol Sci
29287311Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. (2018 Apr)Mok AArthritis Rheumatol