Gene: MFF

56947
C2orf33|EMPF2|GL004
mitochondrial fission factor
protein-coding
2q36.3
Ensembl:ENSG00000168958 MIM:614785 Vega:OTTHUMG00000133180 UniprotKB:Q9GZY8
NG_033153.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.406e-1 (AD)  5.969e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMC40.95
GABARAPL20.95
CALM20.948
PSMD100.947
MAP1LC3B0.945
TCEAL80.944
VAPA0.943
MORF4L10.942
EID10.942
HNRNPK0.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.85
OR4F29-0.82
MTRNR2L6-0.261
MTRNR2L10-0.245
C8orf74-0.242
KLRB1-0.241
MTRNR2L3-0.241
MTRNR2L9-0.24
KCNJ15-0.216
TTLL10-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of MFF mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of MFF mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MFF mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MFF mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MFF mRNA22228805
C006780bisphenol Abisphenol A affects the expression of MFF mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MFF mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MFF mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of MFF mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MFF mRNA18804290
D002737ChloropreneChloroprene results in increased expression of MFF mRNA23125180
D003042CocaineCocaine affects the expression of MFF mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of MFF mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MFF mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MFF mRNA21266533
D004026DieldrinDieldrin results in increased expression of MFF mRNA28385952
D004317DoxorubicinDoxorubicin results in increased expression of MFF mRNA21040762
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of MFF mRNA21040762
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MFF mRNA17555576
D018120FinasterideFinasteride results in increased expression of MFF mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MFF mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MFF mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MFF mRNA28628672
D007854LeadLead affects the splicing of MFF mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MFF mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of MFF promoter"26251327
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of MFF mRNA24128854
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MFF mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MFF mRNA]"21673326
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MFF protein26879310
D011192Potassium DichromatePotassium Dichromate results in increased expression of MFF mRNA23608068
D013467SulindacSulindac results in decreased expression of MFF mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MFF mRNA21570461
D014635Valproic AcidValproic Acid results in decreased expression of MFF mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MFF gene25560391
C025643vinclozolinvinclozolin results in increased expression of MFF mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of MFF mRNA20044591
D015215Zidovudine[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA28683400
D015215Zidovudine[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein28683400
D015032ZincZinc deficiency results in decreased expression of MFF mRNA22171008
D015034Zinc OxideZinc Oxide affects the expression of MFF mRNA28648595

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21149567  
GO:0042803protein homodimerization activity-IDA23530241  
GO ID GO Term Qualifier Evidence PubMed
GO:0000266mitochondrial fission-ISS-  
GO:0001836release of cytochrome c from mitochondria-IMP18353969  
GO:0006626protein targeting to mitochondrion-IMP21149567  
GO:0008053mitochondrial fusion-IMP23921378  
GO:0010821regulation of mitochondrion organization-IMP18353969  21149567  
GO:0016559peroxisome fission-IMP18353969  21149567  
GO:0043653mitochondrial fragmentation involved in apoptotic process-IMP18353969  21149567  
GO:0051260protein homooligomerization-IDA18353969  
GO:0070584mitochondrion morphogenesis-IMP21149567  
GO:0090141positive regulation of mitochondrial fission-IDA23283981  23530241  
GO:0090200positive regulation of release of cytochrome c from mitochondria-IMP21149567  
GO:0090314positive regulation of protein targeting to membrane-IDA23283981  
GO:1900063regulation of peroxisome organization-IMP18353969  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005741mitochondrial outer membrane-IDA21149567  
GO:0005777peroxisome-IDA18353969  23921378  
GO:0008021synaptic vesicle-IEA-  
GO:0030054cell junction-IEA-  
GO:0032592integral component of mitochondrial membrane-IDA18353969  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23756391Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract. (2013 Apr)Wallace JLJ Physiol Pharmacol