Gene: XAB2

56949
HCNP|HCRN|NTC90|SYF1
XPA binding protein 2
protein-coding
19p13.2
Ensembl:ENSG00000076924 MIM:610850 Vega:OTTHUMG00000182404 UniprotKB:Q9HCS7
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.452e-1 (AD)  3.326e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLRMT0.937
UNC45A0.932
MED150.931
ATG4B0.93
DRG20.93
GAK0.929
PCIF10.929
TMEM2590.928
TRIM280.926
NSUN50.926

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.73
OR4F29-0.686
MTRNR2L9-0.335
MTRNR2L6-0.332
MTRNR2L10-0.29
HMHB1-0.263
TTLL10-0.255
KLRB1-0.251
TTLL10-AS1-0.248
OR4F16-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of XAB2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of XAB2 mRNA"21346803
D000643Ammonium ChlorideAmmonium Chloride affects the expression of XAB2 mRNA16483693
D001280AtrazineAtrazine results in increased expression of XAB2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XAB2 mRNA20106945|2049800
C006780bisphenol Abisphenol A affects the expression of XAB2 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of XAB2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride affects the methylation of XAB2 promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of XAB2 mRNA23650126
D002994ClofibrateClofibrate results in decreased expression of XAB2 mRNA23811191
D016572CyclosporineCyclosporine results in increased expression of XAB2 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of XAB2 mRNA24921660
C014347decitabinedecitabine results in increased expression of XAB2 mRNA17908484
D004006DichlorvosXAB2 gene SNP affects the susceptibility to Dichlorvos22102698
D004317DoxorubicinDoxorubicin results in increased expression of XAB2 mRNA25896364
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of XAB2 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XAB2 mRNA17942748
C492448ICG 001ICG 001 results in decreased expression of XAB2 mRNA26191083
D008727MethotrexateMethotrexate affects the expression of XAB2 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of XAB2 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of XAB2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of XAB2 mRNA"25554681
C059514resveratrolresveratrol results in decreased expression of XAB2 protein25505154
D013629TamoxifenTamoxifen affects the expression of XAB2 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XAB2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of XAB2 mRNA21724226
D014212TretinoinXAB2 protein results in decreased susceptibility to Tretinoin17283134
D017974Uranium CompoundsUranium Compounds results in decreased expression of XAB2 mRNA19654044
D014520UrethaneUrethane results in increased expression of XAB2 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10944529  16189514  22365833  25416956  25599396  
GO ID GO Term Qualifier Evidence PubMed
GO:0000349generation of catalytic spliceosome for first transesterification step-IBA21873635  
GO:0000398mRNA splicing, via spliceosome-IBA21873635  
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-IDA28076346  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0001824blastocyst development-IEA-  
GO:0006283transcription-coupled nucleotide-excision repair-IDA10944529  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006351transcription, DNA-templated-IDA10944529  
GO:0021987cerebral cortex development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000974Prp19 complex-IBA21873635  
GO:0005634nucleus-IC10944529  
GO:0005634nucleus-IDA28076346  
GO:0005654nucleoplasm-TAS-  
GO:0016020membrane-HDA19946888  
GO:0071007U2-type catalytic step 2 spliceosome-IDA28076346  
GO:0071013catalytic step 2 spliceosome-IBA21873635  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
GO:0071014post-mRNA release spliceosomal complex-IBA21873635  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73894DNA RepairTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26228655XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population. (2015 Jul 31)Pei NBMC Cancer