Gene: PRTFDC1

56952
HHGP
phosphoribosyl transferase domain containing 1
protein-coding
10p12.1
Ensembl:ENSG00000099256 MIM:610751 Vega:OTTHUMG00000017829 UniprotKB:Q9NRG1
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.825e-1 (AD)  1.274e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7078551chr10:24885797 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEPT20.871
KAT2B0.866
MYO60.861
PTGR20.852
ADD30.851
RMDN10.848
QKI0.843
EFCAB140.841
CRYL10.834
ANP32E0.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.506
OR4F5-0.491
OPRD1-0.454
KLHL38-0.413
FAM160A1-0.4
GDF7-0.389
KCNH5-0.385
SSTR3-0.385
RHO-0.379
MIP-0.378

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PRTFDC1 mRNA"25380136
D020106AcrylamideAcrylamide results in increased expression of PRTFDC1 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PRTFDC1 mRNA24449571
D001151ArsenicArsenic affects the methylation of PRTFDC1 gene25304211
C015001arsenitearsenite results in increased methylation of PRTFDC1 promoter23974009
C006780bisphenol Abisphenol A affects the expression of PRTFDC1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PRTFDC1 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of PRTFDC1 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of PRTFDC1 mRNA24386269
C014347decitabinedecitabine affects the methylation of PRTFDC1 promoter17599052
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PRTFDC1 mRNA25380136
C082360fipronilfipronil results in increased expression of PRTFDC1 mRNA23962444
D005411Flame RetardantsFlame Retardants results in decreased expression of PRTFDC1 mRNA27219277
D005485FlutamideFlutamide results in increased expression of PRTFDC1 mRNA24136188
C039281furanfuran results in increased expression of PRTFDC1 mRNA25539665
D005839GentamicinsGentamicins results in increased expression of PRTFDC1 mRNA22061828
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in decreased expression of PRTFDC1 mRNA27219277
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PRTFDC1 mRNA17183730
C016517indole-3-carbinolindole-3-carbinol affects the expression of PRTFDC1 mRNA21396975
D007213IndomethacinIndomethacin results in increased expression of PRTFDC1 mRNA28201806
C544151jinfukangjinfukang results in decreased expression of PRTFDC1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRTFDC1 mRNA24796395|2675264
D008627Mercuric ChlorideMercuric Chloride affects the expression of PRTFDC1 mRNA20353558
D008701MethapyrileneMethapyrilene results in decreased expression of PRTFDC1 mRNA16393664
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PRTFDC1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PRTFDC1 mRNA23649840
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of PRTFDC1 promoter18448484
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PRTFDC1 mRNA25380136
D009532NickelNickel results in decreased expression of PRTFDC1 mRNA24768652
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PRTFDC1 mRNA25729387
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of PRTFDC1 promoter18448484
D012999SomanSoman results in increased expression of PRTFDC1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRTFDC1 mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRTFDC1 mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PRTFDC1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PRTFDC1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PRTFDC1 mRNA23724009
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PRTFDC1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of PRTFDC1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PRTFDC1 mRNA24383497|2493525
C088658zoledronic acidzoledronic acid results in decreased expression of PRTFDC1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IEA-  
GO:0000287magnesium ion binding-IBA21873635  
GO:0000287magnesium ion binding-TAS21054786  
GO:0004422hypoxanthine phosphoribosyltransferase activity-IBA21873635  
GO:0004422hypoxanthine phosphoribosyltransferase activityNOTIDA21054786  
GO:0005515protein binding-IPI16189514  25416956  25910212  26871637  27107014  
GO:0042803protein homodimerization activity-IPI21054786  
GO ID GO Term Qualifier Evidence PubMed
GO:0006166purine ribonucleoside salvage-IBA21873635  
GO:0006166purine ribonucleoside salvage-IEA-  
GO:0006168adenine salvage-IBA21873635  
GO:0006178guanine salvage-IBA21873635  
GO:0006178guanine salvageNOTIDA21054786  
GO:0032263GMP salvage-IBA21873635  
GO:0032264IMP salvage-IBA21873635  
GO:0046038GMP catabolic processNOTIDA21054786  
GO:0046100hypoxanthine metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal