Gene: SHD

56961
-
Src homology 2 domain containing transforming protein D
protein-coding
19p13.3
Ensembl:ENSG00000105251 MIM:610481 Vega:OTTHUMG00000181879 UniprotKB:Q96IW2
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.461e-1 (AD)  1.935e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHGA0.85
HAPLN40.843
SCN1B0.837
CABP10.836
VSTM2L0.83
EMX10.83
FSD10.822
HR0.821
KCNJ40.814
GABRD0.813

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.507
RAI14-0.477
LRAT-0.472
ZIC4-0.471
NEDD1-0.471
MBNL3-0.462
SFT2D2-0.453
WWTR1-0.45
SOWAHC-0.447
YES1-0.444

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of SHD mRNA22230336
C006780bisphenol Abisphenol A results in decreased expression of SHD mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of SHD mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of SHD mRNA18974090
C014347decitabinedecitabine affects the expression of SHD mRNA23300844
D002945CisplatinCisplatin affects the expression of SHD mRNA23300844
D004147DioxinsDioxins affects the expression of SHD mRNA20463971
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SHD mRNA20044591
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SHD mRNA24810058
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SHD mRNA19710929
C089730rosiglitazonerosiglitazone results in decreased expression of SHD mRNA25572481
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SHD mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SHD mRNA21570461
D014212TretinoinTretinoin results in increased expression of SHD mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SHD mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of SHD mRNA19101580|2352703
C111237vorinostatvorinostat results in decreased expression of SHD mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IBA21873635  
GO:0005515protein binding-IPI24728074  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0009967positive regulation of signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23295013Severe hypovitaminosis D correlates with increased inflammatory markers in HIV infected patients. (2013 Jan 7)Ansemant TBMC Infect Dis