Gene: C14orf132

56967
C14orf88
chromosome 14 open reading frame 132
protein-coding
14q32.2
Ensembl:ENSG00000227051 Vega:OTTHUMG00000171393 UniprotKB:Q9NPU4
NC_000014.9
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.216e-1 (AD)  1.007e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9788546chr14:96059129 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11847860chr14:96045680 (GRCh38.p7)T>A / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12890394chr14:96045020 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARNT20.91
MTA30.901
PIP4K2B0.901
CALM10.893
TUB0.892
KIF3B0.89
TMOD20.89
IDS0.887
SEPT30.886
PPP2R2C0.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.625
OR4F5-0.62
C9orf135-0.388
TFPI2-0.376
BEST3-0.376
CSAG1-0.37
HAS2-0.365
PRRX2-0.365
FCRLA-0.361
SNHG18-0.359

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of C14ORF132 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C14ORF132 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C14ORF132 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
D001280AtrazineAtrazine results in decreased expression of C14ORF132 mRNA22378314
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of C14ORF132 mRNA20404318
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of C14ORF132 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of C14ORF132 mRNA25912373
D000069286BortezomibBortezomib results in decreased expression of C14ORF132 mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of C14ORF132 mRNA26472689
D002220CarbamazepineCarbamazepine affects the expression of C14ORF132 mRNA25979313
C118739entinostatentinostat results in increased expression of C14ORF132 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
D005472FluorouracilFluorouracil results in increased expression of C14ORF132 mRNA16510598
C544151jinfukangjinfukang results in increased expression of C14ORF132 mRNA27392435
D009532NickelNickel results in decreased expression of C14ORF132 mRNA25583101
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of C14ORF132 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of C14ORF132 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of C14ORF132 mRNA23557933
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of C14ORF132 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA19059307
D012643SeleniumSelenium results in decreased expression of C14ORF132 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of C14ORF132 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of C14ORF132 gene28589171
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA19059307
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of C14ORF132 mRNA24935251|2627250
D014635Valproic AcidValproic Acid affects the expression of C14ORF132 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of C14ORF132 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of C14ORF132 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of C14ORF132 mRNA24935251
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C14ORF132 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of C14ORF132 mRNA26272509
C088658zoledronic acidzoledronic acid results in decreased expression of C14ORF132 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal