Gene: PYY

5697
PYY-I|PYY1
peptide YY
protein-coding
17q21.31
Ensembl:ENSG00000131096 MIM:600781 Vega:OTTHUMG00000181801 UniprotKB:P10082
NG_023338.1
PubMed
0   ANCO-SNPs
ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.075e-1 (AD)  3.121e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLX40.617
FUT30.607
PRSS550.529
IGFL10.527
CDH30.522
DHX580.498
TEKT30.496
OVOL10.494
C3orf350.489
DCST20.487

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.361
GDF11-0.301
KIF26B-0.291
RERGL-0.268
VIT-0.268
ZBTB12-0.264
PHOSPHO2-0.26
METTL24-0.259
KCNJ16-0.251
LBH-0.24

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYY mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYY mRNA"27188386
D000535AluminumPYY protein affects the metabolism of Aluminum11709213
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PYY mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PYY mRNA24449571
D001151ArsenicArsenic affects the methylation of PYY gene25304211
D001280AtrazineAtrazine results in decreased expression of PYY mRNA25929836
C403256BIIE 0246BIIE 0246 results in decreased susceptibility to PYY protein22903826
C006780bisphenol Abisphenol A results in decreased expression of PYY mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PYY mRNA26472689
D003471CuprizoneCuprizone results in increased expression of PYY mRNA27523638
C014347decitabinedecitabine affects the expression of PYY mRNA23300844
C007262deoxynivalenoldeoxynivalenol results in increased expression of PYY protein22903826
C007262deoxynivalenoldeoxynivalenol results in increased expression of PYY protein alternative form26979077
C007262deoxynivalenol"N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]"26979077
C007262deoxynivalenol"[Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]"26979077
C007262deoxynivalenolRuthenium Red inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]26979077
C103490dexloxiglumidedexloxiglumide inhibits the reaction [osteum results in increased expression of PYY protein]17138722
D002945CisplatinCisplatin affects the expression of PYY mRNA23300844
D004041Dietary FatsDietary Fats results in increased expression of PYY mRNA18457598|1903023
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of PYY mRNA]19030233
D019422Dietary SucroseDietary Sucrose affects the expression of PYY protein18627777
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PYY mRNA"22485181
C118739entinostatentinostat results in increased expression of PYY mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PYY mRNA"27188386
D005632FructoseFructose affects the expression of PYY protein18627777
D005947GlucoseGlucose affects the expression of PYY protein18627777
D007052IbuprofenIbuprofen results in decreased expression of PYY mRNA17070997
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PYY mRNA25613284
D009020MorphineMorphine results in increased expression of PYY mRNA20144693
D015544Inositol 1,4,5-Trisphosphate"neuropeptide Y (18-36) inhibits the reaction [PYY protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"7742479
D015544Inositol 1,4,5-Trisphosphate"PYX 2 inhibits the reaction [PYY protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"7742479
D015544Inositol 1,4,5-Trisphosphate"PYY protein results in increased abundance of Inositol 1,4,5-Trisphosphate"7742479
C436740N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine"N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]"26979077
C436740N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine"[Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]"26979077
C059889neuropeptide Y (18-36)"neuropeptide Y (18-36) inhibits the reaction [PYY protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"7742479
D000069463Olive OilOlive Oil results in increased expression of PYY protein17138722
D000069463Olive Oilorlistat inhibits the reaction [Olive Oil results in increased expression of PYY protein]17138722
C055122orlistatorlistat inhibits the reaction [Olive Oil results in increased expression of PYY protein]17138722
C055122orlistatorlistat inhibits the reaction [Triglycerides results in increased secretion of PYY protein]15998659
C055122orlistatorlistat results in decreased secretion of PYY protein18647814
C013173osteumdexloxiglumide inhibits the reaction [osteum results in increased expression of PYY protein]17138722
C013173osteumosteum results in increased expression of PYY protein17138722
D010936Plant ExtractsPlant Extracts results in decreased expression of PYY mRNA23557933
C079216PYX 2"PYX 2 inhibits the reaction [PYY protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"7742479
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of PYY mRNA16202921
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of PYY mRNA]19030233
D012430Ruthenium Red"[Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]"26979077
D012430Ruthenium RedRuthenium Red inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]26979077
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PYY mRNA21427059
D012604Scorpion VenomsScorpion Venoms results in increased hydrolysis of PYY protein25239630
D012834SilverSilver results in decreased expression of PYY mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of PYY gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of PYY mRNA18175754
D013549Sweetening AgentsSweetening Agents affects the expression of PYY protein18627777
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PYY mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PYY mRNA25613284
D014280Triglyceridesorlistat inhibits the reaction [Triglycerides results in increased secretion of PYY protein]15998659
D014280TriglyceridesTriglycerides results in increased secretion of PYY protein15998659
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PYY mRNA19042947
D014635Valproic AcidValproic Acid results in increased expression of PYY mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PYY gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of PYY mRNA25423262
C025643vinclozolinvinclozolin results in decreased expression of PYY mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0001664G-protein coupled receptor binding-IPI7493937  7592911  
GO:0005179hormone activity-IBA21873635  
GO:0005179hormone activity-TAS10698177  
GO:0005184neuropeptide hormone activity-IBA21873635  
GO:0005515protein binding-IPI23597562  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007631feeding behavior-IBA21873635  
GO:0007631feeding behavior-TAS10698177  
GO:0008283cell proliferation-TAS10488139  
GO:0010469regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25127083Peptide YY and ghrelin predict craving and risk for relapse in abstinent smokers. (2014 Nov)al'Absi MPsychoneuroendocrinology
21056606Pork, beef and chicken have similar effects on acute satiety and hormonal markers of appetite. (2011 Feb)Charlton KEAppetite
24936806Serum levels of PYY(1-36) peptide in patients with schizophrenia on clozapine monotherapy. (2014 Jul)Wysokinski APharmacopsychiatry
24053729Beneficial association of serum ghrelin and peptide YY with bone mineral density in the Newfoundland population. (2013 Sep 23)Amini PBMC Endocr Disord
22808013The loss of metabolic control on alcohol drinking in heavy drinking alcohol-dependent subjects. (2012)de Timary PPLoS One
21350085Duration of lactation and maternal adipokines at 3 years postpartum. (2011 Apr)Stuebe AMDiabetes
24179100Effects of smoking cessation on beta-cell function, insulin sensitivity, body weight, and appetite. (2014 Feb)Stadler MEur J Endocrinol
26988157No change in serum incretins levels but rise of leptin levels after smoking cessation: a pilot study. (2016 Nov 8)Pankova APhysiol Res
28300626Changes in circulating peptide YY and ghrelin are associated with early smoking relapse. (2018 Jan)Lemieux AMBiol Psychol
24743402The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study. (2014)Cahill FPLoS One
27918953Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis. (2017 Feb)Pendharkar SACytokine