Gene: PRDM9

56979
KMT8B|MEISETZ|MSBP3|PFM6|ZNF899
PR/SET domain 9
protein-coding
5p14.2
Ensembl:ENSG00000164256 MIM:609760 Vega:OTTHUMG00000161918 UniprotKB:Q9NQV7
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.446e-1 (AD)  2.841e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR5T10.782
MYF50.766
OR2W50.764
OR5AS10.762
DUXA0.756
INSL40.754
SLC7A130.751
OR5D160.749
OR52K10.749
OR5M100.749

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDP-0.203
HHATL-0.198
KCNJ10-0.193
PCDH9-0.192
LHFPL1-0.19
MARC1-0.186
FUT9-0.184
OMG-0.183
DIAPH3-0.182
EFCAB1-0.181

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRDM9 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRDM9 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRDM9 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRDM9 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRDM9 mRNA"25510870
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PRDM9 mRNA21298039
D001507BeclomethasoneBeclomethasone results in increased expression of PRDM9 mRNA23656298
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of PRDM9 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of PRDM9 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of PRDM9 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PRDM9 mRNA25181051
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PRDM9 mRNA]27941970
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PRDM9 mRNA25975992
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PRDM9 mRNA"24972896
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PRDM9 mRNA"25926378
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PRDM9 mRNA23103053
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PRDM9 mRNA"25926378
C028007nickel monoxidenickel monoxide results in increased expression of PRDM9 mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRDM9 mRNA"25510870
D011441PropylthiouracilPropylthiouracil results in decreased expression of PRDM9 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRDM9 mRNA21570461
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PRDM9 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0010844recombination hotspot binding-IMP20044539  
GO:0018024histone-lysine N-methyltransferase activity-IMP29072575  
GO:0018024histone-lysine N-methyltransferase activity-TAS-  
GO:0031490chromatin DNA binding-IBA21873635  
GO:0042800histone methyltransferase activity (H3-K4 specific)-IBA21873635  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IMP29072575  
GO:0044212transcription regulatory region DNA binding-IMP29072575  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006311meiotic gene conversion-IDA21750151  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0010845positive regulation of reciprocal meiotic recombination-IBA21873635  
GO:0010845positive regulation of reciprocal meiotic recombination-IMP21750151  
GO:0016584nucleosome positioning-IMP29072575  
GO:0034968histone lysine methylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1474165ReproductionTAS
R-HSA-1500620MeiosisIEA
R-HSA-1500620MeiosisTAS
R-HSA-1640170Cell CycleIEA
R-HSA-1640170Cell CycleTAS
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-912446Meiotic recombinationIEA
R-HSA-912446Meiotic recombinationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24603440The rate of nonallelic homologous recombination in males is highly variable, correlated between monozygotic twins and independent of age. (2014 Mar)MacArthur JAPLoS Genet