Gene: ADAMTS9

56999
-
ADAM metallopeptidase with thrombospondin type 1 motif 9
protein-coding
3p14.1
Ensembl:ENSG00000163638 MIM:605421 Vega:OTTHUMG00000158722 UniprotKB:Q9P2N4
NC_000003.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.968e-1 (AD)  2.272e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1014640chr3:64557939 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL4A10.887
STC10.872
CD930.871
IL1R10.868
CDK20.862
GABRE0.859
MPZL20.858
IL4R0.856
OSMR0.85
ITGB30.849

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.545
NEUROD6-0.539
MARCH4-0.525
TMEM179-0.506
DLX1-0.492
SLC7A4-0.491
EDN3-0.49
CRH-0.49
KIT-0.49
SMIM18-0.488

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ADAMTS9 mRNA19933214
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADAMTS9 mRNA"21346803
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of ADAMTS9 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ADAMTS9 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of ADAMTS9 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of ADAMTS9 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADAMTS9 mRNA22100608
D001104ArbutinArbutin results in decreased expression of ADAMTS9 mRNA17103032
D001152ArsenicalsArsenicals results in decreased expression of ADAMTS9 mRNA28625800
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of ADAMTS9 mRNA"25757056
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADAMTS9 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADAMTS9 mRNA21569818|2261060
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ADAMTS9 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of ADAMTS9 mRNA21185374
C006780bisphenol Abisphenol A results in increased expression of ADAMTS9 mRNA19371625
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADAMTS9 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ADAMTS9 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADAMTS9 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS9 mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of ADAMTS9 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of ADAMTS9 mRNA26577399
D003520CyclophosphamideCyclophosphamide results in increased expression of ADAMTS9 mRNA27281708
D003561CytarabineCytarabine results in decreased expression of ADAMTS9 mRNA21198554
D003907DexamethasoneDexamethasone results in increased expression of ADAMTS9 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADAMTS9 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADAMTS9 mRNA28628672
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ADAMTS9 mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ADAMTS9 mRNA19371625
D002117CalcitriolCalcitriol results in increased expression of ADAMTS9 mRNA26485663
D004237DiuronDiuron metabolite results in increased expression of ADAMTS9 mRNA24172598
C118739entinostatentinostat results in decreased expression of ADAMTS9 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADAMTS9 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ADAMTS9 mRNA17557909
D015025ZearalenoneZearalenone results in increased expression of ADAMTS9 mRNA19371625
D015025ZearalenoneZearalenone results in decreased expression of ADAMTS9 mRNA17557909
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of ADAMTS9 mRNA]15016801
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS9 mRNA20938992
C039281furanfuran results in increased expression of ADAMTS9 mRNA27387713
C039281furanfuran results in increased methylation of ADAMTS9 gene22079235
D019833GenisteinGenistein results in increased expression of ADAMTS9 mRNA19371625
D005944GlucosamineGlucosamine results in decreased cleavage of ADAMTS9 protein alternative form19909832
C004312glycidolglycidol results in decreased expression of ADAMTS9 mRNA24915197
D017313FenretinideFenretinide results in increased expression of ADAMTS9 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ADAMTS9 mRNA21179406
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADAMTS9 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADAMTS9 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADAMTS9 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADAMTS9 mRNA28628672
D008694MethamphetamineMethamphetamine results in increased expression of ADAMTS9 mRNA26307267
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of ADAMTS9 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of ADAMTS9 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS9 mRNA20938992
D015735MifepristoneMifepristone results in decreased expression of ADAMTS9 mRNA25972201
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ADAMTS9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADAMTS9 mRNA"25554681
D019829NevirapineNevirapine metabolite results in decreased expression of ADAMTS9 mRNA23947594
D019829NevirapineNevirapine results in decreased expression of ADAMTS9 mRNA23947594
D009532NickelNickel results in increased expression of ADAMTS9 mRNA25583101
C016340o,p'-DDT"o,p'-DDT results in increased expression of ADAMTS9 mRNA"19371625
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ADAMTS9 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ADAMTS9 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of ADAMTS9 mRNA26516004
D010126OzoneOzone results in increased expression of ADAMTS9 mRNA28623178
D010672PhenytoinPhenytoin results in increased expression of ADAMTS9 mRNA20345932
C006253pirinixic acidpirinixic acid results in increased expression of ADAMTS9 mRNA20813756
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ADAMTS9 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of ADAMTS9 mRNA21540246
D011441PropylthiouracilPropylthiouracil results in increased expression of ADAMTS9 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ADAMTS9 mRNA27029645
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of ADAMTS9 mRNA19564919
C534628SCH 23390SCH 23390 results in decreased expression of ADAMTS9 mRNA19564919
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ADAMTS9 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in increased expression of ADAMTS9 mRNA23221170
D012834SilverSilver results in decreased expression of ADAMTS9 mRNA26551752
D012834SilverSilver results in decreased expression of ADAMTS9 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of ADAMTS9 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of ADAMTS9 gene28589171
D012999SomanSoman results in increased expression of ADAMTS9 mRNA19281266
D053260SootSoot results in increased expression of ADAMTS9 mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADAMTS9 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADAMTS9 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADAMTS9 mRNA19933214
D019284ThapsigarginThapsigargin results in decreased expression of ADAMTS9 mRNA22378314
C009495titanium dioxidetitanium dioxide affects the expression of ADAMTS9 mRNA23557971
C009495titanium dioxidetitanium dioxide results in decreased expression of ADAMTS9 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ADAMTS9 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ADAMTS9 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ADAMTS9 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ADAMTS9 mRNA24935251|2627250
D014415TunicamycinTunicamycin results in decreased expression of ADAMTS9 mRNA22378314
C406224valdecoxibvaldecoxib results in decreased expression of ADAMTS9 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ADAMTS9 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of ADAMTS9 mRNA24896083
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS9 mRNA"27188386
C088658zoledronic acidzoledronic acid results in increased expression of ADAMTS9 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IEA-  
GO:0008237metallopeptidase activity-IDA12514189  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003179heart valve morphogenesis-ISS-  
GO:0003229ventricular cardiac muscle tissue development-ISS-  
GO:0006508proteolysis-IDA12514189  
GO:0006516glycoprotein catabolic process-TAS10936055  
GO:0007275multicellular organism development-TAS10936055  
GO:0010596negative regulation of endothelial cell migration-ISS-  
GO:0015031protein transport-IEA-  
GO:0016192vesicle-mediated transport-IEA-  
GO:0030198extracellular matrix organization-ISS-  
GO:0035909aorta morphogenesis-ISS-  
GO:0045636positive regulation of melanocyte differentiation-IEA-  
GO:0090673endothelial cell-matrix adhesion-ISS-  
GO:1903671negative regulation of sprouting angiogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005783endoplasmic reticulum-IDA-  
GO:0009986cell surface-IEA-  
GO:0031012extracellular matrix-IDA12514189  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26503507Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. (2015 Oct 26)Steele MPBMC Genomics
27453436Methylation of a panel of genes in peripheral blood leukocytes is associated with colorectal cancer. (2016 Jul 25)Luo XSci Rep
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes
24098343Genome-wide association study of gene by smoking interactions in coronary artery calcification. (2013)Polfus LMPLoS One