Gene info: ID 5701

Gene: PSMC2

GENE ID: 5701

Synonyms: MSS1|Nbla10058|S7

Description: proteasome 26S subunit, ATPase 2

Gene type: protein-coding

Location: 7q22.1

dbXrefs: Ensembl:ENSG00000161057 MIM:154365 Vega:OTTHUMG00000157206 UniprotKB:P35998

RefSeq: NC_000007.14

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.737e-1 (AD) 7.879e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PSMA1	0.967
PSMD6	0.967
CDC123	0.965
PSMD14	0.963
XRCC6	0.959
HNRNPH2	0.958
VAPA	0.957
SSB	0.956
GDI2	0.953
PSMC1	0.952

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.744
OR4F29	-0.702
MTRNR2L6	-0.347
MTRNR2L9	-0.334
MTRNR2L10	-0.302
MTRNR2L3	-0.25
MTRNR2L2	-0.243
TTLL10	-0.241
KLRB1	-0.239
C8orf74	-0.239

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of PSMC2 mRNA"	15375163
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of PSMC2 mRNA	15890375
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of PSMC2 mRNA"	18648102
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMC2 mRNA	15890375
D000082	Acetaminophen	Acetaminophen results in decreased expression of PSMC2 mRNA	21420995\|2649742
D000082	Acetaminophen	Acetaminophen results in increased expression of PSMC2 protein	16538041
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PSMC2 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PSMC2 mRNA	15890375
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PSMC2 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of PSMC2 gene	25304211
C058317	arsenic disulfide	arsenic disulfide affects the expression of PSMC2 mRNA	12776498
C058317	arsenic disulfide	arsenic disulfide results in increased expression of PSMC2 mRNA	12890387
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PSMC2 protein	19364129
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of PSMC2 mRNA	15894607
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of PSMC2 mRNA	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PSMC2 protein	20097212
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PSMC2 mRNA	21715664\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PSMC2 mRNA"	20018196
C095105	bexarotene	bexarotene results in increased expression of PSMC2 mRNA	16648578
C006780	bisphenol A	bisphenol A affects the expression of PSMC2 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of PSMC2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of PSMC2 mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in decreased expression of PSMC2 protein	28903499
C515564	bromovanin	bromovanin results in decreased expression of PSMC2 protein	21419150
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PSMC2 mRNA	19031917
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PSMC2 mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of PSMC2 promoter	22457795
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of PSMC2 mRNA	18636392
C100187	chloropicrin	chloropicrin results in increased expression of PSMC2 mRNA	26352163
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of PSMC2 protein	28596144
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PSMC2 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of PSMC2 mRNA	20106945
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PSMC2 mRNA	21266533
C000944	dicrotophos	dicrotophos results in decreased expression of PSMC2 mRNA	28302478
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of PSMC2 mRNA	21318169
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of PSMC2 mRNA	15890375
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of PSMC2 mRNA	15890375
D004147	Dioxins	Dioxins affects the expression of PSMC2 mRNA	20463971
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of PSMC2 mRNA	20064776
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PSMC2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PSMC2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMC2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PSMC2 mRNA	29097150
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of PSMC2 intron	27776689
D018120	Finasteride	Finasteride results in increased expression of PSMC2 mRNA	24136188
D005419	Flavonoids	Flavonoids results in decreased expression of PSMC2 mRNA	18035473
D005485	Flutamide	Flutamide results in increased expression of PSMC2 mRNA	24136188
D005839	Gentamicins	Gentamicins results in increased expression of PSMC2 mRNA	22061828
D006820	Hyaluronic Acid	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PSMC2 protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PSMC2 mRNA	20044591
D006861	Hydrogen Peroxide	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PSMC2 protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of PSMC2 protein	23178681
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of PSMC2 mRNA	19376150
D048628	Ketolides	Ketolides analog results in decreased expression of PSMC2 mRNA	24967691
D007854	Lead	Lead affects the expression of PSMC2 mRNA	28903495
D008148	Lovastatin	Lovastatin results in decreased expression of PSMC2 mRNA	20493250
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of PSMC2 mRNA	20353558
D008701	Methapyrilene	Methapyrilene results in increased expression of PSMC2 mRNA	15890375
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PSMC2 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PSMC2 mRNA	23649840
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC2 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC2 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC2 mRNA]"	20230807
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to PSMC2 protein]	17220478
D016686	Monocrotaline	Monocrotaline results in increased expression of PSMC2 mRNA	18801959
C051752	nefazodone	nefazodone results in increased expression of PSMC2 mRNA	24136188
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC2 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC2 mRNA]"	20230807
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of PSMC2 mRNA	17616710
C025256	nonylphenol	nonylphenol results in decreased expression of PSMC2 protein	19260726
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of PSMC2 mRNA	17725831
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of PSMC2 mRNA	18636392
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of PSMC2 mRNA alternative form	18501439
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PSMC2 mRNA	19162173\|2131816
D010634	Phenobarbital	Phenobarbital results in increased expression of PSMC2 mRNA	19162173
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of PSMC2 mRNA	15890375\|2248451
C006253	pirinixic acid	pirinixic acid results in increased expression of PSMC2 mRNA	15890375
D010894	Piroxicam	Piroxicam results in decreased expression of PSMC2 mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of PSMC2 mRNA	23557933
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of PSMC2 mRNA	22579512
C015586	propiverine	propiverine binds to PSMC2 protein	29273565
C031280	pyrazole	pyrazole results in increased expression of PSMC2 mRNA	17945193
C009277	sodium arsenate	sodium arsenate results in decreased expression of PSMC2 mRNA	23922661
C009277	sodium arsenate	sodium arsenate results in increased expression of PSMC2 mRNA	16882884
D013467	Sulindac	Sulindac results in increased expression of PSMC2 mRNA	24136188
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of PSMC2 mRNA	16184548
D013629	Tamoxifen	Tamoxifen affects the expression of PSMC2 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PSMC2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMC2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PSMC2 mRNA	17942748\|1946511
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PSMC2 mRNA	26232522
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PSMC2 protein	19201780
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of PSMC2 protein	16343552
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PSMC2 mRNA	28065790
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of PSMC2 mRNA	15894607
D014212	Tretinoin	Tretinoin results in decreased expression of PSMC2 mRNA	17218384
C012589	trichostatin A	trichostatin A results in decreased expression of PSMC2 mRNA	24935251
C406224	valdecoxib	valdecoxib results in increased expression of PSMC2 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of PSMC2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PSMC2 mRNA	23179753
D014635	Valproic Acid	Valproic Acid affects the expression of PSMC2 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of PSMC2 mRNA	21318169
D014859	Warfarin	Warfarin results in decreased expression of PSMC2 mRNA	20493250

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	16189514 16763564 17353931 19490896 21516116 22078707 22901813 25416956 26496610 27107012
GO:0005524	ATP binding	-	IEA	-
GO:0016887	ATPase activity	-	IDA	9295362
GO:0017025	TBP-class protein binding	-	IBA	21873635
GO:0036402	proteasome-activating ATPase activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001649	osteoblast differentiation	-	HDA	16210410
GO:0006511	ubiquitin-dependent protein catabolic process	-	IDA	9295362
GO:0016032	viral process	-	IEA	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0030433	ubiquitin-dependent ERAD pathway	-	IBA	21873635
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043687	post-translational protein modification	-	TAS	-
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	-	IBA	21873635
GO:1901800	positive regulation of proteasomal protein catabolic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000502	proteasome complex	-	IDA	9295362 17323924
GO:0000932	P-body	-	ISS	-
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	HDA	21630459
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	TAS	16130169
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0008540	proteasome regulatory particle, base subcomplex	-	IBA	21873635
GO:0016020	membrane	-	HDA	16210410 19946888
GO:0022624	proteasome accessory complex	-	ISS	-
GO:0031595	nuclear proteasome complex	-	IBA	21873635
GO:0031597	cytosolic proteasome complex	-	IBA	21873635
GO:0034774	secretory granule lumen	-	TAS	-
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	-
GO:0043197	dendritic spine	-	IBA	21873635
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-

KEGG ID	KEGG Term
hsa03050	Proteasome

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	IEA
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	TAS
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	TAS
R-HSA-1236974	ER-Phagosome pathway	IEA
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1236975	Antigen processing-Cross presentation	IEA
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-169911	Regulation of Apoptosis	IEA
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	TAS
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	TAS
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	TAS
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	TAS
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	TAS
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	TAS
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	TAS
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	TAS
R-HSA-180534	Vpu mediated degradation of CD4	TAS
R-HSA-180585	Vif-mediated degradation of APOBEC3G	TAS
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2262749	Cellular response to hypoxia	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	TAS
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	TAS
R-HSA-351202	Metabolism of polyamines	TAS
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382556	ABC-family proteins mediated transport	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-4086400	PCP/CE pathway	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	TAS
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453276	Regulation of mitotic cell cycle	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-4608870	Asymmetric localization of PCP proteins	TAS
R-HSA-4641257	Degradation of AXIN	TAS
R-HSA-4641258	Degradation of DVL	TAS
R-HSA-5357801	Programmed Cell Death	IEA
R-HSA-5358346	Hedgehog ligand biogenesis	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5358351	Signaling by Hedgehog	IEA
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	TAS
R-HSA-5387390	Hh mutants abrogate ligand secretion	TAS
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5610780	Degradation of GLI1 by the proteasome	TAS
R-HSA-5610783	Degradation of GLI2 by the proteasome	IEA
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	TAS
R-HSA-5610787	Hedgehog 'off' state	IEA
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5632684	Hedgehog 'on' state	TAS
R-HSA-5658442	Regulation of RAS by GAPs	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	TAS
R-HSA-5678895	Defective CFTR causes cystic fibrosis	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689603	UCH proteinases	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	TAS
R-HSA-68867	Assembly of the pre-replicative complex	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-68949	Orc1 removal from chromatin	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	TAS
R-HSA-69052	Switching of origins to a post-replicative state	TAS
R-HSA-69202	Cyclin E associated events during G1/S transition	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69541	Stabilization of p53	TAS
R-HSA-69563	p53-Dependent G1 DNA Damage Response	TAS
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	TAS
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	TAS
R-HSA-69610	p53-Independent DNA Damage Response	TAS
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	TAS
R-HSA-69615	G1/S DNA Damage Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	TAS
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	TAS
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA
R-HSA-8941858	Regulation of RUNX3 expression and activity	TAS
R-HSA-8948751	Regulation of PTEN stability and activity	TAS
R-HSA-8951664	Neddylation	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	IEA
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal