Gene info: ID 57016

Gene: AKR1B10

GENE ID: 57016

Synonyms: AKR1B11|AKR1B12|ALDRLn|ARL-1|ARL1|HIS|HSI

Description: aldo-keto reductase family 1 member B10

Gene type: protein-coding

Location: 7q33

dbXrefs: Ensembl:ENSG00000198074 MIM:604707 Vega:OTTHUMG00000155356 UniprotKB:O60218

RefSeq: NC_000007.14

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 9

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.027e-1 (AD) 3.032e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PITX1	0.651
DAZ1	0.631
MUC21	0.62
SPRR3	0.61
KRT13	0.608
SPINK5	0.597
KRT6A	0.595
TMPRSS11B	0.595
SPRR1B	0.595
SPRR1A	0.594

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PTPN21	-0.19
KRBA2	-0.19
HSD17B13	-0.187
PCDHB11	-0.182
PPP1R14D	-0.18
PCDHB6	-0.18
GABRR2	-0.18
PADI4	-0.177
PCDHGA3	-0.177
TCTE3	-0.171

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00605	Sulindac	Small Molecule	38194-50-2	Approved\|Investigational	Target
DB02021	Fidarestat	Small Molecule	136087-85-9	Experimental	Target
DB02383	Tolrestat	Small Molecule	82964-04-3	Withdrawn	Target
DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small Molecule		Experimental	Target
DB06246	Exisulind	Small Molecule	59973-80-7	Investigational	Target
DB08772	3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C012277	1,2-diamino-4-nitrobenzene	"1,2-diamino-4-nitrobenzene results in increased expression of AKR1B10 mRNA"	26198647
C016515	1-indanol	AKR1B10 protein results in increased oxidation of 1-indanol	19013440
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of AKR1B10 mRNA"	21920950
C026978	2,3-butylene glycol	"[AKR1B10 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol"	23295224
C043231	2,3-hexanedione	"AKR1B10 protein results in increased reduction of 2,3-hexanedione"	23295224
C043231	2,3-hexanedione	"[AKR1B10 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones"	23295224
C013186	2,3-pentanedione	"AKR1B10 protein results in increased reduction of 2,3-pentanedione"	23295224
C013186	2,3-pentanedione	"[AKR1B10 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones"	23295224
C079389	2,4-hexadienal	"AKR1B10 protein results in increased reduction of 2,4-hexadienal"	21329684
C079389	2,4-hexadienal	"AKR1B10 protein results in increased reduction of 2,4-hexadienal metabolite"	21329684
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKR1B10 protein	23994249
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in increased expression of AKR1B10 mRNA"	20406850
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	"2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of AKR1B10 mRNA"	26198647
C012796	2-butenal	2-butenal affects the metabolism of AKR1B10 protein	17597105
C012796	2-butenal	AKR1B10 protein results in decreased susceptibility to 2-butenal	17597105
C012796	2-butenal	AKR1B10 protein results in increased reduction of 2-butenal	21329684
C012796	2-butenal	AKR1B10 protein results in increased reduction of 2-butenal metabolite	21329684
C091423	2-chloromethylpyridine	2-chloromethylpyridine results in increased expression of AKR1B10 mRNA	26198647
C051750	2-hexenal	AKR1B10 protein results in increased reduction of 2-hexenal	21329684
C051750	2-hexenal	AKR1B10 protein results in increased reduction of 2-hexenal metabolite	21329684
C051290	2-tert-butyl-4-quinone	AKR1B10 protein results in increased reduction of and results in decreased susceptibility to 2-tert-butyl-4-quinone metabolite	25289770
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of AKR1B10 mRNA	25716159
C021338	3-hydroxybenzo(a)pyrene	3-hydroxybenzo(a)pyrene results in increased expression of AKR1B10 mRNA	26238291
C038864	4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid analog binds to AKR1B10 protein"	28161411
C507711	4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid	4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid results in decreased activity of AKR1B10 protein	23220004
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B10 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal	27417252
C027576	4-hydroxy-2-nonenal	AKR1B10 protein results in increased reduction of 4-hydroxy-2-nonenal	19013440\|2132968
C027576	4-hydroxy-2-nonenal	Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]	27417252
C057180	4-hydroxyretinal	AKR1B10 protein results in increased reduction of 4-hydroxyretinal	19014918
C072956	4-nitrososulfamethoxazole	4-nitrososulfamethoxazole results in increased expression of AKR1B10 mRNA	28444390
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	drospirenone inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Estradiol inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Ethinyl Estradiol inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Progesterone inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Testosterone inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C403894	4-oxo-2-nonenal	4-oxo-2-nonenal results in decreased activity of AKR1B10 protein	19013440
C403894	4-oxo-2-nonenal	AKR1B10 protein results in increased metabolism of 4-oxo-2-nonenal	27417252
C403894	4-oxo-2-nonenal	AKR1B10 protein results in increased reduction of 4-oxo-2-nonenal	19013440
C403894	4-oxo-2-nonenal	Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-oxo-2-nonenal]	27417252
C403894	4-oxo-2-nonenal	AKR1B10 protein results in increased reduction of 4-oxo-2-nonenal	23261715
C099660	4-oxoretinaldehyde	AKR1B10 protein results in increased reduction of 4-oxoretinaldehyde	19014918
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B10 mRNA"	27188386
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of AKR1B10 mRNA"	26238291
C005399	9,10-phenanthrenequinone	"9,10-phenanthrenequinone results in increased expression of AKR1B10 mRNA"	24813866
C005399	9,10-phenanthrenequinone	"AKR1B10 protein results in increased metabolism of 9,10-phenanthrenequinone"	24813866
C031390	9-cis-retinal	AKR1B10 protein results in increased reduction of 9-cis-retinal	21851338
D000082	Acetaminophen	Acetaminophen results in decreased expression of AKR1B10 mRNA	21420995\|2906747
D000093	Acetoin	AKR1B10 protein results in increased reduction of Acetoin	23295224
D000093	Acetoin	"[AKR1B10 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol"	23295224
D000093	Acetoin	[AKR1B10 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin	23295224
D000171	Acrolein	Acrolein affects the metabolism of AKR1B10 protein	17597105
D000171	Acrolein	AKR1B10 protein affects the metabolism of Acrolein	17329238
D000171	Acrolein	AKR1B10 protein results in decreased susceptibility to Acrolein	17329238\|1759710
D000171	Acrolein	AKR1B10 protein results in increased reduction of Acrolein	21329684
D000171	Acrolein	AKR1B10 protein results in increased reduction of Acrolein metabolite	21329684
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of AKR1B10 mRNA	23630614
D000393	Air Pollutants	Air Pollutants results in increased expression of AKR1B10 mRNA	23649983
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of AKR1B10 mRNA	28522335
D000658	Amoxicillin	Amoxicillin results in increased expression of AKR1B10 mRNA	28444390
D000667	Ampicillin	Ampicillin results in decreased expression of AKR1B10 mRNA	21632981\|2619864
C031385	anthranilic acid	anthranilic acid results in increased expression of AKR1B10 mRNA	26198647
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of AKR1B10 mRNA	28713220
C006632	arsenic trioxide	AKR1B10 protein results in decreased susceptibility to arsenic trioxide	20707922
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of AKR1B10 mRNA	26198647
D001379	Azathioprine	Azathioprine results in increased expression of AKR1B10 mRNA	22623647\|2619864
C051597	Bandrowski's base	Bandrowski's base results in increased expression of AKR1B10 mRNA	20566472
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of AKR1B10 mRNA	22236718
C029876	benzidine	benzidine results in increased expression of AKR1B10 mRNA	26198647
C030233	benzo(a)pyrene-1,6-quinone	"AKR1B10 protein results in increased reduction of and affects the activity of benzo(a)pyrene-1,6-quinone"	21910479
C018003	benzo(a)pyrene-3,6-quinone	"AKR1B10 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone"	21910479
C017228	benzo(a)pyrene 7,8-dihydrodiol	"[AKR1B10 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol"	21910479
C076588	benzo(a)pyrene-7,8-dione	"[AKR1B10 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione"	21910479
D019817	Benzoic Acid	Benzoic Acid results in increased expression of AKR1B10 mRNA	20566472
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AKR1B10 mRNA	16545412\|2006483
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AKR1B10 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of AKR1B10 mRNA	21839799
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1B10 mRNA	21215737
D004958	Estradiol	Estradiol results in decreased expression of AKR1B10 mRNA	25321415
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of AKR1B10 mRNA	17404688
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of AKR1B10 mRNA	26496021
D004958	Estradiol	Estradiol inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C006780	bisphenol A	[potassium bromate co-treated with bisphenol A] affects the expression of AKR1B10 mRNA	27082013
C006780	bisphenol A	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AKR1B10 mRNA]	27082013
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of AKR1B10 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of AKR1B10 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of AKR1B10 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of AKR1B10 mRNA	26198647
D000069286	Bortezomib	Bortezomib results in increased expression of AKR1B10 mRNA	21215737
D000069286	Bortezomib	Bortezomib results in increased expression of AKR1B10 protein	21215737
D003931	Diacetyl	AKR1B10 protein results in increased reduction of Diacetyl	23295224
D003931	Diacetyl	[AKR1B10 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin	23295224
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of AKR1B10 mRNA	23410634
D002104	Cadmium	Cadmium results in increased expression of AKR1B10 mRNA	21120746\|2117241
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1B10 mRNA	18654764
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester results in decreased activity of AKR1B10 protein	27163852
D002220	Carbamazepine	Carbamazepine affects the expression of AKR1B10 mRNA	25979313
D002699	Chlorambucil	Chlorambucil results in decreased expression of AKR1B10 mRNA	26198647
D002731	4-Chloromercuribenzenesulfonate	4-Chloromercuribenzenesulfonate results in decreased activity of AKR1B10 protein	23261715
D002731	4-Chloromercuribenzenesulfonate	4-Chloromercuribenzenesulfonate results in increased activity of AKR1B10 protein	23261715
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased activity of AKR1B10 protein	23261715
D002911	Chrysenes	AKR1B10 protein results in increased reduction of and affects the activity of Chrysenes	21910479
C043561	chrysin	chrysin results in decreased expression of AKR1B10 mRNA	23994249
C043561	chrysin	chrysin results in decreased expression of AKR1B10 protein	23994249
C043561	chrysin	chrysin inhibits the reaction [[NFE2L2 protein results in increased expression of [HMOX1 protein co-treated with AKR1B10 protein co-treated with ABCC5 protein]] which results in decreased susceptibility to Doxorubicin]	23994249
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of AKR1B10 mRNA	20566472
C019304	ciprofibrate	ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
C019304	ciprofibrate	ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
C019304	ciprofibrate	ciprofibrate results in decreased activity of AKR1B10 protein	18325492
C019304	ciprofibrate	ciprofibrate results in decreased activity of AKR1B10 protein mutant form	18325492
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1B10 mRNA	18654764
D009249	NADP	[AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde	17329238
D009249	NADP	"[AKR1B10 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol"	21910479
D009249	NADP	"[AKR1B10 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione"	21910479
D009249	NADP	AKR1B10 protein results in decreased reduction of NADP	19013440
D009249	NADP	NADP binds to AKR1B10 protein mutant form binds to fidarestat	23295227
D009249	NADP	NADP results in increased activity of AKR1B10 protein	23295224
D009249	NADP	NADP inhibits the reaction [Glutathione Disulfide results in increased activity of AKR1B10 protein]	23261715
D009249	NADP	NADP binds to AKR1B10 protein binds to tolrestat	23295227
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of AKR1B10 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of AKR1B10 mRNA	19549813
D003407	Creosote	Creosote results in increased expression of AKR1B10 mRNA	19389177
C013453	cresidine	cresidine results in increased expression of AKR1B10 mRNA	26198647
D016572	Cyclosporine	Cyclosporine results in decreased expression of AKR1B10 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of AKR1B10 mRNA	25562108
D003630	Daunorubicin	AKR1B10 protein results in decreased susceptibility to Daunorubicin	19028477
D003630	Daunorubicin	AKR1B10 protein results in increased reduction of Daunorubicin	19028477
D003630	Daunorubicin	[AKR1B10 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol	19028477
D003630	Daunorubicin	ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
D003630	Daunorubicin	ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
D003630	Daunorubicin	Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
D003630	Daunorubicin	fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
D003630	Daunorubicin	pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
D003630	Daunorubicin	sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
D003630	Daunorubicin	zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
D003630	Daunorubicin	AKR1B10 protein results in decreased susceptibility to Daunorubicin	21640744
D003630	Daunorubicin	AKR1B10 protein results in increased reduction of Daunorubicin	21640744
D003630	Daunorubicin	[epalrestat results in decreased activity of AKR1B10 protein] which results in increased susceptibility to Daunorubicin	21640744
C000847	daunorubicinol	[AKR1B10 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol	19028477
C000847	daunorubicinol	AKR1B10 protein results in increased chemical synthesis of daunorubicinol	21640744
D003634	DDT	DDT results in increased expression of AKR1B10 mRNA	26198647
C017184	dehydroretinal	AKR1B10 protein results in increased reduction of dehydroretinal	19014918
D015255	Idarubicin	AKR1B10 protein results in decreased susceptibility to Idarubicin	21640744
D015255	Idarubicin	AKR1B10 protein results in increased reduction of Idarubicin	21640744
D015255	Idarubicin	[epalrestat results in decreased activity of AKR1B10 protein] which results in increased susceptibility to Idarubicin	21640744
D002945	Cisplatin	AKR1B10 protein results in decreased susceptibility to Cisplatin	27417252
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of AKR1B10 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of AKR1B10 mRNA	19561079\|2739243
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of AKR1B10 mRNA	28412506
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1B10 mRNA	14656948
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of AKR1B10 mRNA	26198647
D004101	Dihydroxydihydrobenzopyrenes	AKR1B10 protein results in increased reduction of and affects the activity of Dihydroxydihydrobenzopyrenes	21910479
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of AKR1B10 mRNA"	26198647
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of AKR1B10 mRNA	20566472
D004178	Diquat	Diquat results in increased expression of AKR1B10 mRNA	21172416
D004221	Disulfiram	Disulfiram results in increased expression of AKR1B10 mRNA	20566472
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased activity of AKR1B10 protein]	23261715
D004317	Doxorubicin	AKR1B10 protein results in decreased susceptibility to Doxorubicin	25686905
D004317	Doxorubicin	[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA	25686905
D004317	Doxorubicin	[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased phosphorylation of MAPK1 protein	25686905
D004317	Doxorubicin	[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased phosphorylation of MAPK3 protein	25686905
D004317	Doxorubicin	[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein	25686905
D004317	Doxorubicin	Oleanolic Acid inhibits the reaction [AKR1B10 protein results in decreased susceptibility to Doxorubicin]	25686905
D004317	Doxorubicin	Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]	25686905
D004317	Doxorubicin	Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]	25686905
D004317	Doxorubicin	chrysin inhibits the reaction [[NFE2L2 protein results in increased expression of [HMOX1 protein co-treated with AKR1B10 protein co-treated with ABCC5 protein]] which results in decreased susceptibility to Doxorubicin]	23994249
D004317	Doxorubicin	[NFE2L2 protein results in increased expression of [HMOX1 protein co-treated with AKR1B10 protein co-treated with ABCC5 protein]] which results in decreased susceptibility to Doxorubicin	23994249
C035144	drospirenone	drospirenone inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C038131	epalrestat	epalrestat results in decreased activity of AKR1B10 protein	21640744
C038131	epalrestat	[epalrestat results in decreased activity of AKR1B10 protein] which results in increased susceptibility to Daunorubicin	21640744
C038131	epalrestat	[epalrestat results in decreased activity of AKR1B10 protein] which results in increased susceptibility to Idarubicin	21640744
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
D005015	Ethoxyquin	Ethoxyquin results in increased expression of AKR1B10 mRNA	21277289
D005015	Ethoxyquin	NFE2L2 protein promotes the reaction [Ethoxyquin results in increased expression of AKR1B10 mRNA]	21277289
C067822	ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate	ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
C067822	ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate	ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
C067822	ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate	ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate results in decreased activity of AKR1B10 protein	18325492
C040833	ethyl acrylate	ethyl acrylate results in increased expression of AKR1B10 mRNA	26198647
D005054	Eugenol	Eugenol results in increased expression of AKR1B10 mRNA	20566472\|2619864
C084519	farnesal	AKR1B10 protein results in increased reduction of farnesal	21187079
D005204	Farnesol	AKR1B10 protein results in increased chemical synthesis of Farnesol	21187079
D011345	Fenofibrate	Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
D011345	Fenofibrate	Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
D011345	Fenofibrate	Fenofibrate results in decreased activity of AKR1B10 protein	18325492
D011345	Fenofibrate	Fenofibrate results in decreased activity of AKR1B10 protein mutant form	18325492
C006012	fenofibric acid	fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
C006012	fenofibric acid	fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
C006012	fenofibric acid	fenofibric acid results in decreased activity of AKR1B10 protein	18325492
C006012	fenofibric acid	fenofibric acid results in decreased activity of AKR1B10 protein mutant form	18325492
C077139	fidarestat	fidarestat binds to and results in decreased activity of AKR1B10 protein mutant form	23295227
C077139	fidarestat	NADP binds to AKR1B10 protein mutant form binds to fidarestat	23295227
D005436	Floxacillin	Floxacillin results in increased expression of AKR1B10 mRNA	28444390
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of AKR1B10 mRNA	26198647
D015073	2-Acetylaminofluorene	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1B10 mRNA	14656948
D005472	Fluorouracil	Fluorouracil affects the expression of AKR1B10 mRNA	16584549
D005557	Formaldehyde	Formaldehyde results in decreased expression of AKR1B10 mRNA	27664576
C039281	furan	furan results in increased expression of AKR1B10 mRNA	25539665
D015248	Gemfibrozil	Gemfibrozil results in decreased activity of AKR1B10 protein mutant form	18325492
C017338	geranylgeraniol	AKR1B10 protein results in increased chemical synthesis of geranylgeraniol	21187079
D005978	Glutathione	Glutathione inhibits the reaction [Glutathione Disulfide results in increased activity of AKR1B10 protein]	23261715
D019803	Glutathione Disulfide	Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased activity of AKR1B10 protein]	23261715
D019803	Glutathione Disulfide	Glutathione Disulfide results in increased glutathionylation of and results in increased activity of AKR1B10 protein	23261715
D019803	Glutathione Disulfide	Glutathione inhibits the reaction [Glutathione Disulfide results in increased activity of AKR1B10 protein]	23261715
D019803	Glutathione Disulfide	NADP inhibits the reaction [Glutathione Disulfide results in increased activity of AKR1B10 protein]	23261715
D005985	Glyceraldehyde	[AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde	17329238
D005985	Glyceraldehyde	AKR1B10 protein results in increased metabolism of Glyceraldehyde	18325492
D005985	Glyceraldehyde	AKR1B10 protein results in increased reduction of Glyceraldehyde	19014918\|1902847
D005985	Glyceraldehyde	ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
D005985	Glyceraldehyde	ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
D005985	Glyceraldehyde	Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
D005985	Glyceraldehyde	fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
D005985	Glyceraldehyde	pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
D005985	Glyceraldehyde	sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
D005985	Glyceraldehyde	zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
C071834	glycidamide	glycidamide results in increased expression of AKR1B10 mRNA	17822822
D006588	Hexanones	"[AKR1B10 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones"	23295224
D006588	Hexanones	[AKR1B10 protein results in increased reduction of Hexanones] which results in increased chemical synthesis of propioin	23295224
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of AKR1B10 mRNA	20566472
D017313	Fenretinide	Fenretinide results in increased expression of AKR1B10 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of AKR1B10 mRNA	23410634
C054440	idarubicinol	AKR1B10 protein results in increased chemical synthesis of idarubicinol	21640744
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AKR1B10 mRNA	25613284
C018575	isocaproaldehyde	AKR1B10 protein results in increased reduction of isocaproaldehyde	19013440
C036643	isoeugenol	isoeugenol results in increased expression of AKR1B10 mRNA	20566472
D007538	Isoniazid	Isoniazid results in increased expression of AKR1B10 mRNA	28444390
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of AKR1B10 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of AKR1B10 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of AKR1B10 mRNA	26752646
C410337	K 7174	K 7174 results in increased expression of AKR1B10 mRNA	24086573
D019344	Lactic Acid	Lactic Acid results in increased expression of AKR1B10 mRNA	20566472
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1B10 mRNA	18654764
C029891	lead chloride	lead chloride results in increased expression of AKR1B10 mRNA	18654764
D008753	Methylenebis(chloroaniline)	Methylenebis(chloroaniline) results in increased expression of AKR1B10 mRNA	26198647
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of AKR1B10 mRNA	25270620
C033069	methyl salicylate	methyl salicylate results in increased expression of AKR1B10 mRNA	20566472
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of AKR1B10 mRNA	23876855
D009151	Mustard Gas	Mustard Gas results in increased expression of AKR1B10 mRNA	25102026
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of AKR1B10 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of AKR1B10 mRNA"	25554681
D009281	Naphthalenes	AKR1B10 protein results in increased reduction of and affects the activity of Naphthalenes	21910479
C026385	n-hexane	n-hexane results in increased expression of AKR1B10 mRNA	20566472
D009532	Nickel	Nickel results in increased expression of AKR1B10 mRNA	25583101
C029938	nickel sulfate	nickel sulfate results in increased expression of AKR1B10 mRNA	20566472
C570897	NSC668394	NSC668394 results in increased expression of AKR1B10 mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of AKR1B10 mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in decreased expression of AKR1B10 mRNA	18417182
D009828	Oleanolic Acid	Oleanolic Acid inhibits the reaction [AKR1B10 protein results in decreased susceptibility to Doxorubicin]	25686905
D009828	Oleanolic Acid	Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]	25686905
D009828	Oleanolic Acid	Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]	25686905
D009828	Oleanolic Acid	Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]	27417252
D009828	Oleanolic Acid	Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-oxo-2-nonenal]	27417252
D052638	Particulate Matter	Particulate Matter results in increased expression of AKR1B10 mRNA	24769257
D010422	Pentanones	"[AKR1B10 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones"	23295224
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of AKR1B10 mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of AKR1B10 mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of AKR1B10 protein	26879310
C011272	perfosfamide	AKR1B10 protein affects the susceptibility to perfosfamide	18473730
D010634	Phenobarbital	Phenobarbital affects the expression of AKR1B10 mRNA	19084549
D019800	Phenol	Phenol results in increased expression of AKR1B10 mRNA	26198647
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B10 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of AKR1B10 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AKR1B10 mRNA	19710929
C006253	pirinixic acid	pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
C006253	pirinixic acid	pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
C006253	pirinixic acid	pirinixic acid results in decreased activity of AKR1B10 protein	18325492
C006253	pirinixic acid	pirinixic acid results in decreased activity of AKR1B10 protein mutant form	18325492
C006253	pirinixic acid	pirinixic acid results in increased expression of AKR1B10 mRNA	26198647
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AKR1B10 mRNA	19710929
C019536	potassium bromate	potassium bromate affects the expression of AKR1B10 mRNA	27082013
C019536	potassium bromate	[potassium bromate co-treated with bisphenol A] affects the expression of AKR1B10 mRNA	27082013
C019536	potassium bromate	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of AKR1B10 mRNA]	27082013
C019536	potassium bromate	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AKR1B10 mRNA]	27082013
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of AKR1B10 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of AKR1B10 mRNA	17404688
D011374	Progesterone	Progesterone inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
D019840	2-Propanol	2-Propanol results in increased expression of AKR1B10 mRNA	20566472
C523189	propioin	[AKR1B10 protein results in increased reduction of Hexanones] which results in increased chemical synthesis of propioin	23295224
D011794	Quercetin	Quercetin results in decreased expression of AKR1B10 mRNA	21632981
C502851	quinocetone	quinocetone results in decreased expression of AKR1B10 mRNA	27046791
D015125	Oxyquinoline	Oxyquinoline results in increased expression of AKR1B10 mRNA	21632981\|2619864
D012110	Reserpine	Reserpine results in increased expression of AKR1B10 mRNA	26198647
C031389	resorcinol	resorcinol results in increased expression of AKR1B10 mRNA	22623647\|2619864
C059514	resveratrol	[resveratrol co-treated with HMGB1 protein] results in increased expression of AKR1B10 mRNA	25979658
D012172	Retinaldehyde	AKR1B10 protein results in increased metabolism of Retinaldehyde	21329680
D012172	Retinaldehyde	AKR1B10 protein results in increased reduction of Retinaldehyde	19014918
D012172	Retinaldehyde	AKR1B10 protein results in increased metabolism of Retinaldehyde metabolite	23220004
C089730	rosiglitazone	[PPARG protein co-treated with rosiglitazone] results in decreased expression of AKR1B10 protein	27417252
C089730	rosiglitazone	rosiglitazone results in increased expression of AKR1B10 mRNA	21515302
C040115	shogaol	shogaol metabolite results in increased expression of AKR1B10 protein	25148906
C040115	shogaol	shogaol results in increased expression of AKR1B10 mRNA	25148906
C040115	shogaol	shogaol results in increased expression of AKR1B10 protein	25148906
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of AKR1B10 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased secretion of AKR1B10 protein	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of AKR1B10 mRNA	19073995
D012834	Silver	Silver results in increased expression of AKR1B10 mRNA	26014281
D012906	Smoke	Smoke results in decreased expression of AKR1B10 mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in increased expression of AKR1B10 mRNA	23876855\|2549360
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of AKR1B10 mRNA	20566472
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
C026411	sorbinil	sorbinil results in decreased activity of AKR1B10 protein	18325492
C016766	sulforafan	sulforafan results in increased expression of AKR1B10 mRNA	24383545
D013467	Sulindac	Sulindac analog binds to and results in decreased activity of AKR1B10 protein	25532697
D013467	Sulindac	Sulindac binds to and results in decreased activity of AKR1B10 protein	25532697
C025463	sulindac sulfone	sulindac sulfone binds to and results in decreased activity of AKR1B10 protein	25532697
D013739	Testosterone	Testosterone inhibits the reaction [AKR1B10 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AKR1B10 mRNA	20106945\|2163298
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of AKR1B10 mRNA	25463304\|2619864
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of AKR1B10 protein	25463304
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate results in increased expression of JUN mRNA] which results in decreased expression of AKR1B10 mRNA	25463304
D013755	Tetradecanoylphorbol Acetate	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of AKR1B10 mRNA]	25463304
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AKR1B10 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of AKR1B10 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased phosphorylation of AKR1B10 protein	21439344
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of AKR1B10 mRNA	27404394
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of AKR1B10 mRNA	27865774
C040550	tolrestat	NADP binds to AKR1B10 protein binds to tolrestat	23295227
C057693	troglitazone	troglitazone results in increased expression of AKR1B10 mRNA	25572481
C113580	U 0126	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of AKR1B10 mRNA]	25463304
C113580	U 0126	U 0126 results in decreased expression of AKR1B10 protein	23994249
D014520	Urethane	Urethane results in decreased expression of AKR1B10 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of AKR1B10 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of AKR1B10 mRNA	29154799
D014801	Vitamin A	AKR1B10 protein results in decreased susceptibility to Vitamin A	19014918
D014801	Vitamin A	AKR1B10 protein results in decreased susceptibility to Vitamin A metabolite	19014918
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of AKR1B10 mRNA	23410634
C067172	zopolrestat	zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]	19028477
C067172	zopolrestat	zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	19028477
C067172	zopolrestat	zopolrestat results in decreased activity of AKR1B10 protein	18325492
C067172	zopolrestat	zopolrestat results in decreased activity of AKR1B10 protein mutant form	18325492

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001758	retinal dehydrogenase activity	-	IDA	21851338
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	-	IBA	21873635
GO:0004033	aldo-keto reductase (NADP) activity	-	TAS	9565553
GO:0005515	protein binding	-	IPI	18056116 21044950
GO:0008106	alcohol dehydrogenase (NADP+) activity	-	IBA	21873635
GO:0016491	oxidoreductase activity	-	IBA	21873635
GO:0045550	geranylgeranyl reductase activity	-	IDA	21187079
GO:0047718	indanol dehydrogenase activity	-	IDA	20837989

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001523	retinoid metabolic process	-	TAS	-
GO:0016488	farnesol catabolic process	-	IDA	21187079
GO:0044597	daunorubicin metabolic process	-	IMP	20837989
GO:0044598	doxorubicin metabolic process	-	IMP	20837989
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005764	lysosome	-	IEA	-
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00051	Fructose and mannose metabolism
hsa00591	Linoleic acid metabolism
hsa00650	Butanoate metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-196854	Metabolism of vitamins and cofactors	TAS
R-HSA-2187338	Visual phototransduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-6806667	Metabolism of fat-soluble vitamins	TAS
R-HSA-975634	Retinoid metabolism and transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19442055	Fibrates in the chemical action of daunorubicin. (2009 May)	Balendiran GK	Curr Cancer Drug Targets
24598757	Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design. (2014 Mar)	Cousido-Siah A	Acta Crystallogr D Biol Crystallogr
24451080	Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)	Szymanowska-Narloch A	Adv Med Sci
19028477	Cancer biomarker AKR1B10 and carbonyl metabolism. (2009 Mar 16)	Balendiran GK	Chem Biol Interact
25887478	Genetic variants in AKR1B10 associate with human eating behavior. (2015 Mar 25)	Rohde K	BMC Genet
21672310	AKR1B10 is associated with smoking and smoking-related non-small-cell lung cancer. (2011)	Kang MW	J Int Med Res
18358633	AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer. (2008)	Li CP	Pathol Res Pract
22222635	Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma. (2012 May)	Chung YT	Mod Pathol
28743530	Different inhibitory potential of sex hormones on NNK detoxification in vitro: A possible explanation for gender-specific lung cancer risk. (2017 Oct 1)	Stapelfeld C	Cancer Lett