Gene: CCNL1

57018
ANIA6A|BM-001|PRO1073|ania-6a
cyclin L1
protein-coding
3q25.31
Ensembl:ENSG00000163660 MIM:613384 Vega:OTTHUMG00000158713 UniprotKB:Q9UK58
NC_000003.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.573e-3 (AD)  9.622e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CEP950.846
RIPK10.834
FNBP40.823
SMC50.82
HDAC70.809
PRPF30.803
ARHGAP170.797
ZNF2740.797
ZNF7000.791
SLC8B10.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.493
OR4F5-0.473
HAPLN1-0.251
KIT-0.245
PRLHR-0.241
HNF1A-0.24
CRH-0.24
CYP1A1-0.24
WNT7A-0.228
LYPD8-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CCNL1 mRNA"19162173
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CCNL1 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CCNL1 mRNA"19095052
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CCNL1 mRNA16788091
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of CCNL1 mRNA"19561079
D000079AcetaldehydeAcetaldehyde results in increased expression of CCNL1 mRNA23416264
D000082AcetaminophenAcetaminophen results in decreased expression of CCNL1 mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of CCNL1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of CCNL1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CCNL1 mRNA15749267
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCNL1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCNL1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCNL1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CCNL1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CCNL1 mRNA"18687144
D001280AtrazineAtrazine results in increased expression of CCNL1 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of CCNL1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CCNL1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CCNL1 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CCNL1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCNL1 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of CCNL1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CCNL1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CCNL1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CCNL1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of CCNL1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CCNL1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CCNL1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCNL1 mRNA19010381
D002211CapsaicinCapsaicin results in increased expression of CCNL1 mRNA20349343
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CCNL1 mRNA23650126
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CCNL1 mRNA27858113
D003024ClozapineClozapine results in increased expression of CCNL1 mRNA15860345
D003033Coal TarCoal Tar results in decreased expression of CCNL1 mRNA27858113
D003042CocaineCocaine results in increased expression of CCNL1 mRNA16076954
D019327Copper SulfateCopper Sulfate results in decreased expression of CCNL1 mRNA21595052
D019327Copper SulfateCopper Sulfate results in increased expression of CCNL1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CCNL1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of CCNL1 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CCNL1 mRNA21266533
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CCNL1 mRNA"27840820
D004317DoxorubicinDoxorubicin results in increased expression of CCNL1 mRNA25896364
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CCNL1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CCNL1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CCNL1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CCNL1 mRNA17942748
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CCNL1 mRNA28329830
D005557FormaldehydeFormaldehyde results in decreased expression of CCNL1 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of CCNL1 mRNA17938736|2065599
C069837fullerene C60fullerene C60 results in decreased expression of CCNL1 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of CCNL1 mRNA22061828
D005947GlucoseGlucose results in increased expression of CCNL1 mRNA17178593
D006220HaloperidolHaloperidol results in increased expression of CCNL1 mRNA15860345
D017313FenretinideFenretinide results in increased expression of CCNL1 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of CCNL1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCNL1 mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of CCNL1 mRNA17085751
C410337K 7174K 7174 results in increased expression of CCNL1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of CCNL1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of CCNL1 mRNA19751817
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCNL1 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of CCNL1 mRNA]16415329
D008694MethamphetamineMethamphetamine results in increased expression of CCNL1 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CCNL1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CCNL1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CCNL1 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of CCNL1 mRNA15674844
D009151Mustard GasMustard Gas affects the expression of CCNL1 mRNA15651846
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CCNL1 mRNA"29244179
C051752nefazodonenefazodone results in decreased expression of CCNL1 mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of CCNL1 mRNA19167457
C016030pantogabpantogab results in increased expression of CCNL1 mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CCNL1 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of CCNL1 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of CCNL1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of CCNL1 mRNA19270015
C006253pirinixic acidpirinixic acid results in increased expression of CCNL1 mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of CCNL1 mRNA19162173|2248451
D010938Plant OilsPlant Oils results in increased expression of CCNL1 mRNA23370395
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CCNL1 mRNA24583197
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CCNL1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CCNL1 mRNA22079256
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of CCNL1 mRNA]16415329
C059514resveratrolresveratrol results in increased expression of CCNL1 mRNA23419489
C089730rosiglitazonerosiglitazone results in decreased expression of CCNL1 mRNA17639046
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of CCNL1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCNL1 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCNL1 mRNA19073995
D012834SilverSilver results in increased expression of CCNL1 mRNA26014281
D012999SomanSoman results in increased expression of CCNL1 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of CCNL1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCNL1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCNL1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CCNL1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCNL1 mRNA17942748|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCNL1 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCNL1 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCNL1 mRNA15358164
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCNL1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of CCNL1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CCNL1 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CCNL1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of CCNL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CCNL1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of CCNL1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of CCNL1 mRNA15799026|1913645
C025643vinclozolinvinclozolin results in increased expression of CCNL1 mRNA23034163
D014750VincristineVincristine results in decreased expression of CCNL1 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of CCNL1 mRNA19244175
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CCNL1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  26496610  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006396RNA processing-IEA-  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:1901409positive regulation of phosphorylation of RNA polymerase II C-terminal domain-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17494991  
GO:0016607nuclear speck-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21885063Replication of a genome-wide association study of birth weight in preterm neonates. (2012 Jan)Ryckman KKJ Pediatr
24278325Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013)Urashima MPLoS One
20372150Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. (2010 May)Freathy RMNat Genet
23202124New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. (2013 Jan)Horikoshi MNat Genet