Gene: SLC17A7

57030
BNPI|VGLUT1
solute carrier family 17 member 7
protein-coding
19q13.33
Ensembl:ENSG00000104888 MIM:605208 Vega:OTTHUMG00000183166 UniprotKB:Q9P2U7
NC_000019.10
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.168e-1 (AD)  8.710e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MPPED10.923
CHD50.915
GABBR20.914
NRN10.913
IGSF210.91
TESPA10.91
STX1A0.906
TMEM1550.905
MEF2C0.904
NPTXR0.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAP1-0.613
ISL1-0.574
IRX1-0.563
LHX8-0.548
SLC5A7-0.541
GHSR-0.536
C1orf87-0.533
SLITRK6-0.53
LRAT-0.516
OR4F5-0.515

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SLC17A7 mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SLC17A7 mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC17A7 mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of SLC17A7 mRNA"23829299
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC17A7 mRNA25607892
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC17A7 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC17A7 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of SLC17A7 protein19932152
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC17A7 mRNA25607892
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SLC17A7 mRNA24449571
C040929bafilomycin A1bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]15860731
C040929bafilomycin A1bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Zinc]15860731
C040929bafilomycin A1bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]]15860731
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC17A7 mRNA22228805
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC17A7 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of SLC17A7 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC17A7 gene28505145
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC17A7 mRNA25607892
D003024ClozapineClozapine results in increased expression of SLC17A7 mRNA16111724
D003024ClozapineClozapine results in increased expression of SLC17A7 protein16111724
D003042CocaineCocaine results in increased expression of SLC17A7 protein25100957
C004692coomassie Brilliant Bluecoomassie Brilliant Blue inhibits the reaction [ALPL gene mutant form results in increased expression of SLC17A7 protein]27466191
D003471CuprizoneCuprizone results in decreased expression of SLC17A7 mRNA26577399
D003891DesipramineDesipramine results in increased expression of SLC17A7 mRNA16111724
D003891DesipramineDesipramine results in increased expression of SLC17A7 protein16111724
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC17A7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLC17A7 mRNA23558232
D002945Cisplatintrichostatin A inhibits the reaction [Cisplatin results in decreased expression of SLC17A7 mRNA]23558232
C061132diphenyldiselenidediphenyldiselenide results in decreased expression of SLC17A7 protein19926633
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC17A7 mRNA25607892
D000431EthanolEthanol results in decreased expression of SLC17A7 mRNA20655511
D018683Excitatory Amino Acid Agentsbafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]15860731
D018683Excitatory Amino Acid AgentsSLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents15860731
D018683Excitatory Amino Acid AgentsSLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]15860731
D018683Excitatory Amino Acid AgentsValinomycin inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]15860731
D005473FluoxetineFluoxetine results in increased expression of SLC17A7 mRNA16111724
D005473FluoxetineFluoxetine results in increased expression of SLC17A7 protein16111724
D005473FluoxetineFluoxetine results in decreased expression of SLC17A7 mRNA17033635
D005492Folic AcidFolic Acid results in increased expression of SLC17A7 mRNA25006883
D005492Folic AcidFolic Acid results in increased expression of SLC17A7 protein25006883
C039281furanfuran results in increased methylation of SLC17A7 gene22079235
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC17A7 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SLC17A7 mRNA26752646
D007649KetamineKetamine results in increased expression of SLC17A7 mRNA20080153
D007854LeadLead affects the expression of SLC17A7 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of SLC17A7 mRNA24260418
C008261lead acetatelead acetate results in increased expression of SLC17A7 mRNA24260418
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SLC17A7 mRNA"24972896
D008094LithiumLithium results in increased expression of SLC17A7 mRNA16111724
D008094LithiumLithium results in increased expression of SLC17A7 protein16111724
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC17A7 protein25809596
D009020MorphineMorphine affects the expression of SLC17A7 protein16522322
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC17A7 mRNA25607892
D010269ParaquatParaquat results in decreased expression of SLC17A7 mRNA28467894
C410127PCB 180PCB 180 results in increased expression of SLC17A7 mRNA23829299
D010710PhosphatesSLC17A7 protein results in increased transport of [Sodium co-treated with Phosphates]10962014
D010862PilocarpinePilocarpine results in increased expression of SLC17A7 protein17503488
C006253pirinixic acidpirinixic acid results in increased expression of SLC17A7 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC17A7 mRNA23557933
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of SLC17A7 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of SLC17A7 mRNA15849065
D019782RiluzoleRiluzole results in decreased expression of SLC17A7 protein17507170
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SLC17A7 mRNA21427059
D012834SilverSilver results in decreased expression of SLC17A7 protein27593553
D012834SilverSilver results in increased expression of SLC17A7 mRNA27131904
D012964SodiumSLC17A7 protein results in increased transport of [Sodium co-treated with Phosphates]10962014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC17A7 mRNA24680724
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of SLC17A7 mRNA]27469509
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SLC17A7 mRNA26745549
C012589trichostatin Atrichostatin A inhibits the reaction [Cisplatin results in decreased expression of SLC17A7 mRNA]23558232
D014520UrethaneUrethane results in increased expression of SLC17A7 mRNA28818685
D014634ValinomycinValinomycin inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]15860731
D014635Valproic AcidValproic Acid affects the expression of SLC17A7 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC17A7 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased expression of SLC17A7 protein16169023
D014635Valproic AcidValproic Acid results in increased expression of SLC17A7 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of SLC17A7 protein17507170
D015032Zincbafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Zinc]15860731
D015032Zincbafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]]15860731
D015032ZincSLC17A7 protein results in increased uptake of Zinc15860731
D015032ZincSLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]15860731

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005313L-glutamate transmembrane transporter activity-IBA21873635  
GO:0005313L-glutamate transmembrane transporter activity-TAS-  
GO:0005326neurotransmitter transporter activity-IBA21873635  
GO:0008068extracellularly glutamate-gated chloride channel activity-IEA-  
GO:0015319sodium:inorganic phosphate symporter activity-IBA21873635  
GO:0015319sodium:inorganic phosphate symporter activity-IDA10820226  
GO:0015321sodium-dependent phosphate transmembrane transporter activity-IBA21873635  
GO:0022857transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0003407neural retina development-IEA-  
GO:0006811ion transport-TAS-  
GO:0006817phosphate ion transport-TAS8632143  
GO:0006820anion transport-IBA21873635  
GO:0007420brain development-IEA-  
GO:0007616long-term memory-IEA-  
GO:0014047glutamate secretion-TAS-  
GO:0015813L-glutamate transmembrane transport-IEA-  
GO:0035249synaptic transmission, glutamatergic-IBA21873635  
GO:0035249synaptic transmission, glutamatergic-IEA-  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0042137sequestering of neurotransmitter-IEA-  
GO:0044341sodium-dependent phosphate transport-IEA-  
GO:0050803regulation of synapse structure or activity-IBA21873635  
GO:0051938L-glutamate import-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0097401synaptic vesicle lumen acidification-IEA-  
GO:0098700neurotransmitter loading into synaptic vesicle-IBA21873635  
GO:0098700neurotransmitter loading into synaptic vesicle-IEA-  
GO:1900242regulation of synaptic vesicle endocytosis-IEA-  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IDA10820226  
GO:0030054cell junction-IEA-  
GO:0030285integral component of synaptic vesicle membrane-IBA21873635  
GO:0030285integral component of synaptic vesicle membrane-IEA-  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0030672synaptic vesicle membrane-TAS-  
GO:0044300cerebellar mossy fiber-IEA-  
GO:0048786presynaptic active zone-IEA-  
GO:0060076excitatory synapse-IBA21873635  
GO:0060076excitatory synapse-IEA-  
GO:0060203clathrin-sculpted glutamate transport vesicle membrane-TAS-  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-428643Organic anion transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17928304Smoking and alcoholism target genes associated with plasticity and glutamate transmission in the human ventral tegmental area. (2008 Jan 1)Flatscher-Bader THum Mol Genet