Gene info: ID 57053

Gene: CHRNA10

GENE ID: 57053

Synonyms: -

Description: cholinergic receptor nicotinic alpha 10 subunit

Gene type: protein-coding

Location: 11p15.4

dbXrefs: Ensembl:ENSG00000129749 MIM:606372 Vega:OTTHUMG00000011844 UniprotKB:Q9GZZ6

RefSeq: NC_000011.10

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.938e-1 (AD) 7.363e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2672213	chr11:3670187 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
UCP3	0.719
NOP2	0.606
SRRM5	0.602
MOB3A	0.6
FITM1	0.594
ENGASE	0.591
DHX34	0.591
PLOD3	0.589
CTRL	0.587
GDPD3	0.584

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PARPBP	-0.337
DEPDC4	-0.321
PLK4	-0.318
ARMCX5	-0.317
YEATS4	-0.308
FSTL5	-0.293
CCT6B	-0.285
MPO	-0.285
SLC35G1	-0.284
COL25A1	-0.274

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00184	Nicotine	Small Molecule	54-11-5	Approved	Target
DB00202	Succinylcholine	Small Molecule	306-40-1	Approved	Target
DB00333	Methadone	Small Molecule	76-99-3	Approved	Target
DB00674	Galantamine	Small Molecule	357-70-0	Approved	Target
DB00898	Ethanol	Small Molecule	64-17-5	Approved	Target
DB01090	Pentolinium	Small Molecule	144-44-5	Approved	Target
DB01116	Trimethaphan	Small Molecule	7187-66-8	Approved\|Investigational	Target
DB01161	Chloroprocaine	Small Molecule	133-16-4	Approved	Target
DB05069	ATG003	Small Molecule	-	Investigational	Target
DB05137	Lobeline	Small Molecule	90-69-7	Investigational	Target
DB05740	RPI-78M	Small Molecule	-	Investigational	Target

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHRNA10 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHRNA10 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHRNA10 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHRNA10 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHRNA10 mRNA"	25510870
C026114	2-xylene	2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]	18602458
C031285	3-xylene	3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]	18602458
C031286	4-xylene	4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]	18602458
D000082	Acetaminophen	Acetaminophen results in increased expression of CHRNA10 mRNA	26690555
D000109	Acetylcholine	2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]	18602458
D000109	Acetylcholine	3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]	18602458
D000109	Acetylcholine	4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]	18602458
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]	18602458
D000109	Acetylcholine	ethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]	18602458
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CHRNA10 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CHRNA10 mRNA	16483693
D001554	Benzene	Benzene results in increased expression of CHRNA10 mRNA	19162166
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CHRNA10 mRNA	22300585
C006780	bisphenol A	bisphenol A results in decreased expression of CHRNA10 mRNA	25181051
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of CHRNA10 mRNA	17452286\|1881221
D002994	Clofibrate	Clofibrate results in decreased expression of CHRNA10 mRNA	22300585
C510079	conotoxin alpha-RgIA, Conus regius	"conotoxin alpha-RgIA, Conus regius analog results in decreased activity of [CHRNA9 protein binds to CHRNA10 protein]"	21888386
C510079	conotoxin alpha-RgIA, Conus regius	"conotoxin alpha-RgIA, Conus regius results in decreased activity of [CHRNA9 protein binds to CHRNA10 protein]"	21888386
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of CHRNA10 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of CHRNA10 mRNA	27392435
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of CHRNA10 mRNA	26033743
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in decreased expression of CHRNA10 mRNA"	27840820
C004912	ethylbenzene	ethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]	18602458
C039281	furan	furan results in increased expression of CHRNA10 mRNA	25539665
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of CHRNA10 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of CHRNA10 mRNA	27392435
D009532	Nickel	Nickel results in decreased expression of CHRNA10 mRNA	18812211
C028007	nickel monoxide	nickel monoxide results in decreased expression of CHRNA10 mRNA	19167457
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHRNA10 mRNA"	25510870
D011794	Quercetin	Quercetin results in increased expression of CHRNA10 mRNA	21632981
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CHRNA10 mRNA	25895662
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CHRNA10 mRNA"	26179874
D014635	Valproic Acid	Valproic Acid affects the expression of CHRNA10 mRNA	17963808

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004888	transmembrane signaling receptor activity	-	IEA	-
GO:0005102	signaling receptor binding	-	TAS	11350119
GO:0005230	extracellular ligand-gated ion channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005262	calcium channel activity	-	IEA	-
GO:0022848	acetylcholine-gated cation-selective channel activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	IBA	21873635
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IGI	18420419
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007271	synaptic transmission, cholinergic	-	TAS	11350119
GO:0034220	ion transmembrane transport	-	IBA	21873635
GO:0042127	regulation of cell proliferation	-	TAS	11350119
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0042472	inner ear morphogenesis	-	IEA	-
GO:0050877	nervous system process	-	IBA	21873635
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	-	IEA	-
GO:0060079	excitatory postsynaptic potential	-	IEA	-
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0070588	calcium ion transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0016020	membrane	-	TAS	11350119
GO:0016021	integral component of membrane	-	IEA	-
GO:0030054	cell junction	-	IEA	-
GO:0030424	axon	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0043204	perikaryon	-	IEA	-
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17559419	Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (2008 Mar)	Rigbi A	Genes Brain Behav
19180564	Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. (2009 Oct 5)	Pergadia ML	Am J Med Genet B Neuropsychiatr Genet
27355804	SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. (2016 Jul)	Perez-Rubio G	Pharmacogenomics
26184988	Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. (2015 Sep 30)	Kimbrel NA	Psychiatry Res
21498873	Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)	Keskitalo-Vuokko K	Nicotine Tob Res
20584212	Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010 Oct)	Saccone NL	Genes Brain Behav