Gene: PSMD1

5707
P112|Rpn2|S1
proteasome 26S subunit, non-ATPase 1
protein-coding
2q37.1
Ensembl:ENSG00000173692 MIM:617842 Vega:OTTHUMG00000133223 UniprotKB:Q99460
NC_000002.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.463e-2 (AD)  8.573e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IMMT0.969
DDX240.967
UQCRC20.964
CLTC0.962
PSMC10.96
DCTN20.959
SLC4A1AP0.959
SARS0.959
USP50.957
USP70.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.674
OR4F29-0.638
MTRNR2L6-0.367
MTRNR2L9-0.355
MTRNR2L10-0.331
RAI14-0.329
CSAG1-0.328
KLRB1-0.324
HEY2-0.314
SH2D1A-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PSMD1 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PSMD1 mRNA"20206263
C0194992-nitrofluorene2-nitrofluorene results in increased expression of PSMD1 mRNA15890375
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMD1 mRNA15890375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PSMD1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PSMD1 mRNA15890375
D000638AmiodaroneAmiodarone affects the expression of PSMD1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PSMD1 mRNA16483693
D001151ArsenicArsenic affects the methylation of PSMD1 gene25304211
C058317arsenic disulfidearsenic disulfide affects the expression of PSMD1 mRNA12776498
C058317arsenic disulfidearsenic disulfide results in increased expression of PSMD1 mRNA12890387
C006632arsenic trioxidearsenic trioxide results in increased expression of PSMD1 mRNA20458559
D001553BenzbromaroneBenzbromarone affects the expression of PSMD1 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSMD1 mRNA21715664|2222880
C006780bisphenol Abisphenol A affects the expression of PSMD1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PSMD1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PSMD1 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of PSMD1 protein28903499
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PSMD1 mRNA23650126
D002994ClofibrateClofibrate affects the expression of PSMD1 mRNA19483382
D002994ClofibrateClofibrate results in increased expression of PSMD1 mRNA21318169
C018021cobaltous chloridecobaltous chloride results in increased expression of PSMD1 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in increased expression of PSMD1 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of PSMD1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of PSMD1 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of PSMD1 mRNA17211630
D013759DronabinolDronabinol results in decreased expression of PSMD1 mRNA18454173
D003976DiazinonDiazinon affects the expression of PSMD1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PSMD1 mRNA21266533
D004026DieldrinDieldrin results in increased expression of PSMD1 mRNA20584760
D004026DieldrinDieldrin affects the expression of PSMD1 mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PSMD1 mRNA21318169
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PSMD1 mRNA15890375
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PSMD1 mRNA15890375
D004147DioxinsDioxins affects the expression of PSMD1 mRNA20463971
C512195elesclomolelesclomol results in increased expression of PSMD1 mRNA18723479
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PSMD1 protein23301498
D000431EthanolEthanol affects the expression of PSMD1 mRNA24355176
D005001EthionineEthionine affects the expression of PSMD1 mRNA19483382
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PSMD1 mRNA23649840
D018120FinasterideFinasteride results in increased expression of PSMD1 mRNA24136188
D018120FinasterideFinasteride results in increased expression of PSMD1 protein27750143
C082360fipronilfipronil results in increased expression of PSMD1 mRNA23962444
C061365flusilazoleflusilazole results in decreased expression of PSMD1 mRNA22382673
C061365flusilazoleflusilazole results in increased expression of PSMD1 mRNA22382673
D005485FlutamideFlutamide results in increased expression of PSMD1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PSMD1 mRNA23649840
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PSMD1 mRNA17183730
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of PSMD1 mRNA19376150
D007854LeadLead results in decreased expression of PSMD1 mRNA19921347
C045463leflunomideleflunomide results in increased expression of PSMD1 mRNA24136188
D008094LithiumLithium results in decreased expression of PSMD1 mRNA19949822
D008701MethapyrileneMethapyrilene results in increased expression of PSMD1 mRNA15890375
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PSMD1 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PSMD1 mRNA29191790
C051752nefazodonenefazodone results in increased expression of PSMD1 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of PSMD1 mRNA22546817
C012655nimesulidenimesulide results in increased expression of PSMD1 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PSMD1 mRNA17616710
D009853OmeprazoleOmeprazole affects the expression of PSMD1 mRNA19483382
C016340o,p'-DDT"o,p'-DDT affects the expression of PSMD1 mRNA"17984292
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PSMD1 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PSMD1 protein19954255
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of PSMD1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PSMD1 mRNA20936131
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PSMD1 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of PSMD1 mRNA19429403
D010634PhenobarbitalPhenobarbital results in increased expression of PSMD1 mRNA19162173
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of PSMD1 mRNA15890375|2248451
C006253pirinixic acidpirinixic acid results in increased expression of PSMD1 mRNA21318169|2381119
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of PSMD1 mRNA]21318169
C006253pirinixic acidpirinixic acid affects the expression of PSMD1 mRNA19483382
C006253pirinixic acidpirinixic acid results in increased expression of PSMD1 mRNA15890375
D010936Plant ExtractsPlant Extracts results in increased expression of PSMD1 mRNA23557933
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of PSMD1 mRNA22579512
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PSMD1 mRNA19162173|2131816
C015586propiverinepropiverine binds to PSMD1 protein29273565
D011441PropylthiouracilPropylthiouracil affects the expression of PSMD1 mRNA19483382
D053260SootSoot results in increased expression of PSMD1 mRNA22461453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSMD1 mRNA21570461
D019284ThapsigarginThapsigargin results in decreased expression of PSMD1 mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of PSMD1 mRNA19483382
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PSMD1 mRNA22363418
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PSMD1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of PSMD1 mRNA19448997
D014415TunicamycinTunicamycin results in decreased expression of PSMD1 mRNA22378314
C406224valdecoxibvaldecoxib results in increased expression of PSMD1 mRNA24136188
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PSMD1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of PSMD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PSMD1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PSMD1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of PSMD1 mRNA21318169
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PSMD1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PSMD1 mRNA21126777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI17353931  19490896  
GO:0030234enzyme regulator activity-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI16207813  
GO ID GO Term Qualifier Evidence PubMed
GO:0016579protein deubiquitination-TAS-  
GO:0042176regulation of protein catabolic process-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0050790regulation of catalytic activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000502proteasome complex-IDA17323924  
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
GO:0005838proteasome regulatory particle-TAS8816993  
GO:0008540proteasome regulatory particle, base subcomplex-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0022624proteasome accessory complex-ISS-  
GO:0034515proteasome storage granule-IBA21873635  
GO:0035578azurophil granule lumen-TAS-  
KEGG ID KEGG Term
hsa03050Proteasome
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1169091Activation of NF-kappaB in B cellsTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1236974ER-Phagosome pathwayIEA
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1236975Antigen processing-Cross presentationIEA
R-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)TAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-169911Regulation of ApoptosisIEA
R-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/CTAS
R-HSA-174113SCF-beta-TrCP mediated degradation of Emi1TAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174154APC/C:Cdc20 mediated degradation of SecurinTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-180534Vpu mediated degradation of CD4TAS
R-HSA-180585Vif-mediated degradation of APOBEC3GTAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-211733Regulation of activated PAK-2p34 by proteasome mediated degradationIEA
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2871837FCERI mediated NF-kB activationTAS
R-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1TAS
R-HSA-350562Regulation of ornithine decarboxylase (ODC)TAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-422475Axon guidanceIEA
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-4608870Asymmetric localization of PCP proteinsTAS
R-HSA-4641257Degradation of AXINTAS
R-HSA-4641258Degradation of DVLTAS
R-HSA-5357801Programmed Cell DeathIEA
R-HSA-5358346Hedgehog ligand biogenesisTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERADTAS
R-HSA-5387390Hh mutants abrogate ligand secretionTAS
R-HSA-5607761Dectin-1 mediated noncanonical NF-kB signalingTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5610780Degradation of GLI1 by the proteasomeTAS
R-HSA-5610783Degradation of GLI2 by the proteasomeIEA
R-HSA-5610785GLI3 is processed to GLI3R by the proteasomeTAS
R-HSA-5610787Hedgehog 'off' stateIEA
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5676590NIK-->noncanonical NF-kB signalingTAS
R-HSA-5678895Defective CFTR causes cystic fibrosisTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-68827CDT1 association with the CDC6:ORC:origin complexTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69229Ubiquitin-dependent degradation of Cyclin D1TAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69541Stabilization of p53TAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25ATAS
R-HSA-69610p53-Independent DNA Damage ResponseTAS
R-HSA-69613p53-Independent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75815Ubiquitin-dependent degradation of Cyclin DTAS
R-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointTAS
R-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosisTAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8939902Regulation of RUNX2 expression and activityTAS
R-HSA-8941858Regulation of RUNX3 expression and activityTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-8951664NeddylationTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29762635An Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits. (2018 May 14)Dhana KAm J Epidemiol