Gene info: ID 5708

Gene: PSMD2

GENE ID: 5708

Synonyms: P97|RPN1|S2|TRAP2

Description: proteasome 26S subunit, non-ATPase 2

Gene type: protein-coding

Location: 3q27.1

dbXrefs: Ensembl:ENSG00000175166 MIM:606223 Vega:OTTHUMG00000156796 UniprotKB:Q13200

RefSeq: NC_000003.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.328e-3 (AD) 8.770e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PKM	0.967
AP2B1	0.962
PNMA1	0.962
DCTN2	0.961
APLP2	0.959
MDH2	0.959
GBA2	0.959
PSMD3	0.959
MTCH1	0.959
HK1	0.959

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.771
OR4F29	-0.722
TFPI2	-0.313
IL18RAP	-0.311
CTNNA3	-0.308
MTRNR2L6	-0.306
CST7	-0.304
KLRB1	-0.302
VNN3	-0.301
KCNJ15	-0.301

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PSMD2 mRNA"	21346803
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PSMD2 mRNA	22100608
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PSMD2 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of PSMD2 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of PSMD2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of PSMD2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PSMD2 gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of PSMD2 protein	24874008
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PSMD2 mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PSMD2 mRNA	18974090
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PSMD2 mRNA	19320972\|1937684
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PSMD2 mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of PSMD2 mRNA	17211630
C009160	cyclonite	cyclonite affects the expression of PSMD2 mRNA	21060837
D016572	Cyclosporine	Cyclosporine results in increased expression of PSMD2 mRNA	20106945\|2556210
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PSMD2 mRNA	28628672
D004008	Diclofenac	Diclofenac results in increased expression of PSMD2 mRNA	26934552
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of PSMD2 mRNA	21318169
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PSMD2 mRNA"	22485181
C512195	elesclomol	elesclomol results in increased expression of PSMD2 mRNA	18723479
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PSMD2 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PSMD2 mRNA	24096037
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMD2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PSMD2 mRNA	24096037
D018120	Finasteride	Finasteride results in increased expression of PSMD2 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of PSMD2 mRNA	24136188
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PSMD2 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PSMD2 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PSMD2 mRNA	28628672
D007854	Lead	Lead affects the expression of PSMD2 mRNA	28903495
D007854	Lead	Lead results in decreased expression of PSMD2 mRNA	19921347
C045463	leflunomide	leflunomide results in increased expression of PSMD2 mRNA	24136188
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of PSMD2 mRNA	20353558
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to PSMD2 protein]	17220478
D015741	Metribolone	Metribolone results in increased expression of PSMD2 protein	17152098
D009020	Morphine	Morphine deficiency inhibits the reaction [Morphine results in decreased expression of PSMD2 protein]	23056601
D009020	Morphine	Morphine results in decreased expression of PSMD2 protein	23056601
C051752	nefazodone	nefazodone results in increased expression of PSMD2 mRNA	24136188
C028007	nickel monoxide	nickel monoxide results in increased expression of PSMD2 mRNA	19167457
C012655	nimesulide	nimesulide results in increased expression of PSMD2 mRNA	24136188
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of PSMD2 mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT affects the expression of PSMD2 mRNA"	17984292
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of PSMD2 mRNA"	24096037
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of PSMD2 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of PSMD2 mRNA	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PSMD2 protein	22609092
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of PSMD2 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PSMD2 mRNA	18804290
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of PSMD2 mRNA	22484513
C006253	pirinixic acid	pirinixic acid results in increased expression of PSMD2 mRNA	23811191
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of PSMD2 mRNA	19162173\|2131816
C015586	propiverine	propiverine binds to PSMD2 protein	29273565
C031280	pyrazole	pyrazole results in increased expression of PSMD2 mRNA	17945193
D011794	Quercetin	Quercetin results in increased expression of PSMD2 mRNA	21632981
C021751	tanshinone	tanshinone results in increased expression of PSMD2 mRNA	15849732
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PSMD2 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PSMD2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMD2 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PSMD2 mRNA	25613284
D014241	Trichloroethylene	Trichloroethylene affects the expression of PSMD2 mRNA	21135412
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PSMD2 mRNA	19042947
C406224	valdecoxib	valdecoxib results in increased expression of PSMD2 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased expression of PSMD2 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of PSMD2 mRNA	21318169
C025643	vinclozolin	vinclozolin results in decreased expression of PSMD2 mRNA	23034163
D014810	Vitamin E	Vitamin E results in increased expression of PSMD2 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004175	endopeptidase activity	CONTRIBUTES_TO	IBA	21873635
GO:0005515	protein binding	-	IPI	11278995 14743216 16189514 16763564 16990800 17353931 18457437 18922472 19060904 19490896 19615732 22901813 25036637 25416956 26496610
GO:0030234	enzyme regulator activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0016579	protein deubiquitination	-	TAS	-
GO:0042176	regulation of protein catabolic process	-	IEA	-
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IBA	21873635
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043687	post-translational protein modification	-	TAS	-
GO:0050790	regulation of catalytic activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000502	proteasome complex	-	IDA	17323924
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0005838	proteasome regulatory particle	-	TAS	8774743
GO:0008540	proteasome regulatory particle, base subcomplex	-	IBA	21873635
GO:0016020	membrane	-	HDA	19946888
GO:0022624	proteasome accessory complex	-	ISS	-
GO:0034515	proteasome storage granule	-	IBA	21873635
GO:0034774	secretory granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	20458337
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-

KEGG ID	KEGG Term
hsa03050	Proteasome

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	IEA
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	TAS
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	TAS
R-HSA-1236974	ER-Phagosome pathway	IEA
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1236975	Antigen processing-Cross presentation	IEA
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-169911	Regulation of Apoptosis	IEA
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	TAS
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	TAS
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	TAS
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	TAS
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	TAS
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	TAS
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	TAS
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	TAS
R-HSA-180534	Vpu mediated degradation of CD4	TAS
R-HSA-180585	Vif-mediated degradation of APOBEC3G	TAS
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2262749	Cellular response to hypoxia	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	TAS
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	TAS
R-HSA-351202	Metabolism of polyamines	TAS
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382556	ABC-family proteins mediated transport	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-4086400	PCP/CE pathway	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	TAS
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453276	Regulation of mitotic cell cycle	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-4608870	Asymmetric localization of PCP proteins	TAS
R-HSA-4641257	Degradation of AXIN	TAS
R-HSA-4641258	Degradation of DVL	TAS
R-HSA-5357801	Programmed Cell Death	IEA
R-HSA-5358346	Hedgehog ligand biogenesis	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5358351	Signaling by Hedgehog	IEA
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	TAS
R-HSA-5387390	Hh mutants abrogate ligand secretion	TAS
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5610780	Degradation of GLI1 by the proteasome	TAS
R-HSA-5610783	Degradation of GLI2 by the proteasome	IEA
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	TAS
R-HSA-5610787	Hedgehog 'off' state	IEA
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5632684	Hedgehog 'on' state	TAS
R-HSA-5658442	Regulation of RAS by GAPs	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	TAS
R-HSA-5678895	Defective CFTR causes cystic fibrosis	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689603	UCH proteinases	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	TAS
R-HSA-68867	Assembly of the pre-replicative complex	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-68949	Orc1 removal from chromatin	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	TAS
R-HSA-69052	Switching of origins to a post-replicative state	TAS
R-HSA-69202	Cyclin E associated events during G1/S transition	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69541	Stabilization of p53	TAS
R-HSA-69563	p53-Dependent G1 DNA Damage Response	TAS
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	TAS
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	TAS
R-HSA-69610	p53-Independent DNA Damage Response	TAS
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	TAS
R-HSA-69615	G1/S DNA Damage Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	TAS
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	TAS
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA
R-HSA-8941858	Regulation of RUNX3 expression and activity	TAS
R-HSA-8948751	Regulation of PTEN stability and activity	TAS
R-HSA-8951664	Neddylation	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	IEA
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18671841	PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells. (2008 Jul 31)	Kriegova E	BMC Mol Biol