Gene: ENTPD7

57089
LALP1
ectonucleoside triphosphate diphosphohydrolase 7
protein-coding
10q24.2
Ensembl:ENSG00000198018 MIM:616753 Vega:OTTHUMG00000018888 UniprotKB:Q9NQZ7
NG_053079.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.625e-1 (AD)  7.652e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11813439chr10:99692612 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEATR10.816
CDK120.793
TSTD20.793
SRSF100.789
NRIP10.789
MED10.784
ZNF4260.779
ZNF7780.763
PTPRJ0.761
SMCR80.755

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRC3-0.358
APOA1-0.339
S100A1-0.324
NRN1L-0.308
TNFRSF13B-0.302
KLRC2-0.299
NEU4-0.292
MOBP-0.287
MCM7-0.284
OLIG1-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of ENTPD7 mRNA"21920950
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ENTPD7 gene27153756
C547126AZM551248AZM551248 results in increased expression of ENTPD7 mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of ENTPD7 mRNA29275510
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ENTPD7 mRNA25596134
D002220CarbamazepineCarbamazepine affects the expression of ENTPD7 mRNA24752500
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of ENTPD7 mRNA25596134
C059262cidofovircidofovir results in increased expression of ENTPD7 mRNA25596134
D019327Copper SulfateCopper Sulfate results in decreased expression of ENTPD7 mRNA19549813
D003471CuprizoneCuprizone affects the expression of ENTPD7 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of ENTPD7 mRNA20106945|2559613
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ENTPD7 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of ENTPD7 mRNA24752500
D004026DieldrinDieldrin results in decreased expression of ENTPD7 mRNA23041725
C024629dimethyl phthalatedimethyl phthalate affects the expression of ENTPD7 mRNA26924002
D011345FenofibrateFenofibrate results in decreased expression of ENTPD7 mRNA25596134
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of ENTPD7 mRNA24657277
D005557FormaldehydeFormaldehyde results in decreased expression of ENTPD7 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of ENTPD7 mRNA27664576
D017313FenretinideFenretinide results in decreased expression of ENTPD7 mRNA28973697
D017313FenretinideFenretinide results in increased expression of ENTPD7 mRNA28973697
D019266Iron, Dietary"Iron, Dietary affects the expression of ENTPD7 mRNA"15637178
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ENTPD7 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of ENTPD7 mRNA28988120
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of ENTPD7 mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of ENTPD7 mRNA24657277
D009532NickelNickel results in increased expression of ENTPD7 mRNA24768652|2558310
D010100OxygenOxygen deficiency results in decreased expression of ENTPD7 mRNA25596134
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ENTPD7 mRNA23978341
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ENTPD7 mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of ENTPD7 mRNA23370395
D011192Potassium DichromatePotassium Dichromate results in increased expression of ENTPD7 mRNA23608068
C045950propiconazolepropiconazole results in increased expression of ENTPD7 mRNA21278054
C089730rosiglitazonerosiglitazone results in decreased expression of ENTPD7 mRNA25596134
D012822Silicon DioxideSilicon Dioxide results in increased expression of ENTPD7 mRNA23221170
D012969Sodium FluorideSodium Fluoride results in increased expression of ENTPD7 mRNA27862939
D018038Sodium SeleniteSodium Selenite results in decreased expression of ENTPD7 mRNA18175754
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ENTPD7 mRNA20133372
D014635Valproic AcidValproic Acid affects the expression of ENTPD7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ENTPD7 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ENTPD7 mRNA17292431
C029297vinylidene chloridevinylidene chloride results in increased expression of ENTPD7 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017111nucleoside-triphosphatase activity-EXP11278936  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0034656nucleobase-containing small molecule catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-8850843Phosphate bond hydrolysis by NTPDase proteinsTAS
R-HSA-8956319Nucleobase catabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal