Gene: CASS4

57091
C20orf32|CAS4|HEFL|HEPL
Cas scaffold protein family member 4
protein-coding
20q13.31
Ensembl:ENSG00000087589 Vega:OTTHUMG00000032788 UniprotKB:Q9NQ75
NC_000020.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.216e-1 (AD)  8.203e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLCO2B10.772
CASP100.746
ABCB10.746
VWA20.743
TRIM380.73
THSD40.726
MECOM0.723
SLFN110.722
PAQR50.717
PTPRB0.717

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.407
C1orf53-0.39
CPLX3-0.381
SPATA2L-0.362
GGN-0.356
CRH-0.353
FAM43B-0.35
FBLL1-0.33
TMEM121-0.329
KCNIP3-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of CASS4 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of CASS4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CASS4 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of CASS4 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of CASS4 mRNA25594700
C006780bisphenol Abisphenol A results in increased methylation of CASS4 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of CASS4 mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of CASS4 mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of CASS4 mRNA23125180
D003300CopperCopper deficiency results in increased expression of CASS4 mRNA26033743
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CASS4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CASS4 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of CASS4 mRNA26033743
D017313FenretinideFenretinide results in decreased expression of CASS4 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CASS4 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CASS4 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CASS4 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of CASS4 mRNA28988120
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CASS4 mRNA"25554681
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CASS4 mRNA25895662
D053260SootSoot results in decreased expression of CASS4 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CASS4 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CASS4 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CASS4 mRNA23557971
D014520UrethaneUrethane results in decreased expression of CASS4 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of CASS4 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0016477cell migration-IBA21873635  
GO:0090527actin filament reorganization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membraneCOLOCALIZES_WITHIBA21873635  
GO:0005925focal adhesion-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget