Gene: TIGAR

57103
C12orf5|FR2BP
TP53 induced glycolysis regulatory phosphatase
protein-coding
12p13.32
Ensembl:ENSG00000078237 MIM:610775 Vega:OTTHUMG00000168124 UniprotKB:Q9NQ88
NC_000012.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.531e-1 (AD)  3.982e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of TIGAR mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TIGAR mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIGAR mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to TIGAR protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TIGAR protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIGAR mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TIGAR mRNA22230336
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of TIGAR mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TIGAR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TIGAR mRNA21632981|2164198
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TIGAR mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TIGAR protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TIGAR mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TIGAR mRNA27195522
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TIGAR mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of TIGAR mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TIGAR mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TIGAR mRNA25596134
D002220CarbamazepineCarbamazepine affects the expression of TIGAR mRNA25979313
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of TIGAR mRNA25596134
C059262cidofovircidofovir results in increased expression of TIGAR mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of TIGAR mRNA25596134
D003078ColchicineColchicine results in decreased expression of TIGAR mRNA24211769
D019327Copper SulfateCopper Sulfate results in increased expression of TIGAR mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TIGAR mRNA"19167446
D016572CyclosporineCyclosporine results in decreased expression of TIGAR mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of TIGAR mRNA20106945|2556210
D003703DemecolcineDemecolcine results in increased expression of TIGAR mRNA23649840
D002945CisplatinCisplatin results in increased expression of TIGAR mRNA21532991|2545074
C000944dicrotophosdicrotophos results in decreased expression of TIGAR mRNA28302478
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of TIGAR mRNA20886546
D011397Promegestone[Promegestone co-treated with methoxyacetic acid] results in increased expression of TIGAR mRNA15103026
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TIGAR protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TIGAR mRNA23649840
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of TIGAR mRNA]15016801
D005557FormaldehydeFormaldehyde results in increased expression of TIGAR mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TIGAR mRNA20044591
D007069IfosfamideIfosfamide results in increased expression of TIGAR mRNA25596134
C544151jinfukangjinfukang results in decreased expression of TIGAR mRNA27392435
D008727MethotrexateMethotrexate results in increased expression of TIGAR mRNA21678067
C013598methoxyacetic acid[Promegestone co-treated with methoxyacetic acid] results in increased expression of TIGAR mRNA15103026
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TIGAR mRNA23649840
D009532NickelNickel results in increased expression of TIGAR mRNA24768652|2558310
D010100OxygenOxygen deficiency results in decreased expression of TIGAR mRNA25596134
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of TIGAR mRNA17097637
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIGAR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TIGAR mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of TIGAR mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of TIGAR mRNA18037150
C005556propionaldehydepropionaldehyde results in increased expression of TIGAR mRNA26079696
D011794QuercetinQuercetin results in increased expression of TIGAR mRNA21632981
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of TIGAR mRNA21042727
D017382Reactive Oxygen SpeciesTP53 protein promotes the reaction [Reactive Oxygen Species results in increased expression of TIGAR mRNA]21042727
C059514resveratrolresveratrol results in increased expression of TIGAR protein25505154
D013629TamoxifenTamoxifen results in increased expression of TIGAR mRNA22041887
D013629TamoxifenTIGAR protein results in decreased susceptibility to Tamoxifen22041887
D014415TunicamycinTunicamycin results in increased expression of TIGAR mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of TIGAR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TIGAR mRNA23179753
C025643vinclozolinvinclozolin results in increased expression of TIGAR mRNA22615374
D014750VincristineVincristine results in increased expression of TIGAR mRNA23649840
D000225AdenineAdenine results in decreased expression of TIGAR mRNA24211769
C088658zoledronic acidzoledronic acid results in decreased expression of TIGAR mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004083bisphosphoglycerate 2-phosphatase activity-IDA19015259  
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity-EXP16839880  
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity-IDA19015259  
GO:0005515protein binding-IPI23185017  
GO ID GO Term Qualifier Evidence PubMed
GO:0002931response to ischemia-ISS-  
GO:0006003fructose 2,6-bisphosphate metabolic process-IDA19015259  
GO:0006914autophagy-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0006974cellular response to DNA damage stimulus-IDA25928429  
GO:0009410response to xenobiotic stimulus-IEA-  
GO:0010332response to gamma radiation-IEA-  
GO:0010666positive regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0016311dephosphorylation-IEA-  
GO:0030388fructose 1,6-bisphosphate metabolic process-IDA19015259  
GO:0043069negative regulation of programmed cell death-IDA23185017  
GO:0043456regulation of pentose-phosphate shunt-IMP25928429  
GO:0045739positive regulation of DNA repair-IMP25928429  
GO:0045820negative regulation of glycolytic process-IEA-  
GO:0060576intestinal epithelial cell development-IEA-  
GO:0071279cellular response to cobalt ion-IDA25928429  
GO:0071456cellular response to hypoxia-IDA23185017  
GO:1901215negative regulation of neuron death-IEA-  
GO:1901525negative regulation of mitophagy-IEA-  
GO:1902153regulation of response to DNA damage checkpoint signaling-IMP25928429  
GO:1903301positive regulation of hexokinase activity-IDA23185017  
GO:1904024negative regulation of glucose catabolic process to lactate via pyruvate-IEA-  
GO:2000378negative regulation of reactive oxygen species metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA-  
GO:0005634nucleus-IDA25928429  
GO:0005737cytoplasm-IDA23185017  25928429  
GO:0005741mitochondrial outer membrane-IDA23185017  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00051Fructose and mannose metabolism
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29634976High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma. (2018 Apr 7)Liu JHum Pathol
28816646Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis. (2017 Aug)Solanki HSOMICS
28600657Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group. (2017 Aug)Conwell DLDig Dis Sci