Gene: CYSLTR2

57105
CYSLT2|CYSLT2R|GPCR21|HG57|HPN321|KPG_011|PSEC0146|hGPCR21
cysteinyl leukotriene receptor 2
protein-coding
13q14.2
Ensembl:ENSG00000152207 MIM:605666 Vega:OTTHUMG00000016906 UniprotKB:Q9NS75
NG_051649.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.501e-1 (AD)  5.263e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGAP290.697
LAMC30.679
PDGFRB0.678
COL4A30.664
P2RY140.646
NOTCH30.637
FN10.63
SLC30A100.628
DISC10.623
ABCC90.62

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS1-0.451
C16orf95-0.433
MAGIX-0.426
ERAS-0.422
SMIM18-0.418
CORT-0.416
GNB1L-0.414
DHDH-0.413
NPW-0.409
CHST8-0.407

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00716NedocromilSmall Molecule69049-73-6Approved|InvestigationalTarget
DB08855Leukotriene C4Small Molecule72025-60-6Experimental|InvestigationalTarget
DB11858Leukotriene D4Small Molecule73836-78-9InvestigationalTarget
ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYSLTR2 mRNA16483693
D001241AspirinCYSLTR2 gene SNP affects the susceptibility to Aspirin20485159
D001241AspirinCYSLTR2 polymorphism affects the susceptibility to Aspirin15970796
C071435BAY u9773BAY u9773 binds to and results in decreased activity of CYSLTR2 protein18651869
C071435BAY u9773BAY u9773 binds to and results in decreased activity of CYSLTR2 protein10851239|1865186
C071435BAY u9773BAY u9773 binds to and results in increased activity of CYSLTR2 protein11093801
C071435BAY u9773BAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium]11093801
C071435BAY u9773BAY u9773 binds to and results in decreased activity of CYSLTR2 protein15888248
C006780bisphenol Abisphenol A results in increased expression of CYSLTR2 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of CYSLTR2 mRNA25181051
D002118CalciumBAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium]11093801
D002118Calcium[Leukotriene C4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium11093801
D002118Calcium[Leukotriene C4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium10851239
D002118Calcium[Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium11093801
D002118Calcium[Leukotriene D4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium10851239
D002118Calcium[Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium11093801
D002118Calcium[Leukotriene E4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium10851239
D019327Copper SulfateCopper Sulfate results in increased expression of CYSLTR2 mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CYSLTR2 mRNA23914054
D004041Dietary FatsDietary Fats results in decreased expression of CYSLTR2 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CYSLTR2 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CYSLTR2 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CYSLTR2 gene16495775
D005419FlavonoidsFlavonoids results in decreased expression of CYSLTR2 mRNA18035473
D007854LeadLead results in decreased expression of CYSLTR2 mRNA19921347
D017999Leukotriene E4Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein11093801
D017999Leukotriene E4[Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium11093801
D017999Leukotriene E4Leukotriene E4 results in increased activity of CYSLTR2 protein10851239
D017999Leukotriene E4[Leukotriene E4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium10851239
D017997Leukotriene C4Leukotriene C4 binds to and results in increased activity of CYSLTR2 protein11093801
D017997Leukotriene C4[Leukotriene C4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium11093801
D017997Leukotriene C4Leukotriene C4 results in increased activity of CYSLTR2 protein10851239
D017997Leukotriene C4[Leukotriene C4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium10851239
D017998Leukotriene D4BAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium]11093801
D017998Leukotriene D4Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein10851239|1109380
D017998Leukotriene D4[Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium11093801
D017998Leukotriene D4[Leukotriene D4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium10851239
D017998Leukotriene D4montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]10851239
D017998Leukotriene D4pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]10851239
D017998Leukotriene D4verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]10851239
D017998Leukotriene D4zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]10851239
D017998Leukotriene D4Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein15888248
D008727MethotrexateMethotrexate results in decreased expression of CYSLTR2 mRNA24449571
C093875montelukastmontelukast binds to and results in decreased activity of CYSLTR2 protein10851239
C093875montelukastmontelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]10851239
C006253pirinixic acidpirinixic acid results in decreased expression of CYSLTR2 mRNA20813756
D010936Plant ExtractsPlant Extracts results in increased expression of CYSLTR2 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of CYSLTR2 mRNA16293270
C047681pranlukastpranlukast binds to and results in decreased activity of CYSLTR2 protein10851239
C047681pranlukastpranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]10851239
D013629TamoxifenTamoxifen affects the expression of CYSLTR2 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CYSLTR2 mRNA17942748
C059141verlukastverlukast binds to and results in decreased activity of CYSLTR2 protein10851239
C059141verlukastverlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]10851239
C062735zafirlukastzafirlukast binds to and results in decreased activity of CYSLTR2 protein10851239
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]10851239

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001631cysteinyl leukotriene receptor activity-IEA-  
GO:0004966galanin receptor activity-IBA21873635  
GO:0004974leukotriene receptor activity-NAS10913337  
GO:0005515protein binding-IPI21203429  21525870  24550280  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-NAS10913337  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0010942positive regulation of cell death-IEA-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0061737leukotriene signaling pathway-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-391903Eicosanoid ligand-binding receptorsTAS
R-HSA-391906Leukotriene receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27990118Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. (2016)Thompson MDFront Pharmacol