Gene: PDSS2

57107
C6orf210|COQ10D3|DLP1|bA59I9.3|hDLP1
decaprenyl diphosphate synthase subunit 2
protein-coding
6q21
Ensembl:ENSG00000164494 MIM:610564 Vega:OTTHUMG00000059359 UniprotKB:Q86YH6
NG_013033.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.328e-1 (AD)  6.110e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGGF10.879
JKAMP0.877
KLHL120.877
PPIL10.875
CUL30.873
ASNSD10.868
TAX1BP10.867
TM9SF20.867
USO10.866
CAPRIN10.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.527
MTRNR2L10-0.326
MTRNR2L6-0.321
VNN3-0.313
RSPO1-0.296
TCL1A-0.293
ANPEP-0.278
TNFRSF13B-0.271
ZBTB20-0.271

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PDSS2 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PDSS2 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDSS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDSS2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PDSS2 mRNA26497421
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PDSS2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PDSS2 mRNA22100608|2715375
D000638AmiodaroneAmiodarone results in increased expression of PDSS2 mRNA24489787
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PDSS2 mRNA24449571
D016718Arachidonic AcidArachidonic Acid results in decreased expression of PDSS2 mRNA16704987
D001280AtrazineAtrazine results in decreased expression of PDSS2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDSS2 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDSS2 mRNA21715664
C006780bisphenol Abisphenol A results in decreased expression of PDSS2 mRNA25181051
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of PDSS2 mRNA21308897
D019327Copper SulfateCopper Sulfate results in decreased expression of PDSS2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PDSS2 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of PDSS2 mRNA24317228
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PDSS2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PDSS2 mRNA19561079
D004147DioxinsDioxins affects the expression of PDSS2 mRNA20463971
D004237DiuronDiuron results in increased expression of PDSS2 mRNA21551480
D005485FlutamideFlutamide results in increased expression of PDSS2 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PDSS2 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PDSS2 mRNA20044591
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PDSS2 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PDSS2 mRNA21308897
C492448ICG 001ICG 001 results in increased expression of PDSS2 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of PDSS2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PDSS2 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDSS2 mRNA28001369
D009532NickelNickel results in decreased expression of PDSS2 mRNA24768652|2558310
D010634PhenobarbitalPhenobarbital affects the expression of PDSS2 mRNA19159669
D010936Plant ExtractsPlant Extracts results in increased expression of PDSS2 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of PDSS2 mRNA21632981
D012643SeleniumSelenium results in decreased expression of PDSS2 mRNA19244175
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PDSS2 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PDSS2 protein18951874
D013849ThimerosalThimerosal results in decreased expression of PDSS2 mRNA27188386
C034613triacsin Ctriacsin C results in decreased expression of PDSS2 mRNA16704987
C012589trichostatin Atrichostatin A results in increased expression of PDSS2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PDSS2 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDSS2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PDSS2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PDSS2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of PDSS2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PDSS2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000010trans-hexaprenyltranstransferase activitycontributes_toIDA16262699  
GO:0046982protein heterodimerization activity-IDA16262699  
GO:0050347trans-octaprenyltranstransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006744ubiquinone biosynthetic process-IDA16262699  
GO:0006744ubiquinone biosynthetic process-IEA-  
GO:0008299isoprenoid biosynthetic process-IDA16262699  
GO:0050878regulation of body fluid levels-IEA-  
GO:0051290protein heterotetramerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IDA-  
GO:1990234transferase complex-IDA16262699  
KEGG ID KEGG Term
hsa00900Terpenoid backbone biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2142789Ubiquinol biosynthesisTAS
R-HSA-8978934Metabolism of cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23312889Decrease of PDSS2 expression, a novel tumor suppressor, in non-small cell lung cancer. (2013 Apr)Chen PCancer Epidemiol