Gene: INTS12

57117
INT12|PHF22|SBBI22
integrator complex subunit 12
protein-coding
4q24
Ensembl:ENSG00000138785 MIM:611355 Vega:OTTHUMG00000131215 UniprotKB:Q96CB8
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.849e-1 (AD)  5.220e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TARS0.861
WTAP0.842
EIF2S20.839
OSTC0.835
ERP440.832
LRRC420.827
REXO20.822
COPB10.818
EIF3J0.815
CRK0.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.573
OR4F29-0.541
HES5-0.254
REN-0.233
REM1-0.223
TCL1A-0.223
MYLK2-0.209
SLC6A13-0.198
MUSTN1-0.191
LYZL2-0.184

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of INTS12 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of INTS12 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of INTS12 mRNA"23196670
D000082AcetaminophenAcetaminophen affects the expression of INTS12 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of INTS12 mRNA27153756
C006780bisphenol Abisphenol A affects the expression of INTS12 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of INTS12 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of INTS12 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of INTS12 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of INTS12 gene28505145
D016572CyclosporineCyclosporine results in increased expression of INTS12 mRNA25562108
C000944dicrotophosdicrotophos results in decreased expression of INTS12 mRNA28302478
D005485FlutamideFlutamide results in increased expression of INTS12 mRNA24793618
C045463leflunomideleflunomide results in decreased expression of INTS12 mRNA19751817
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of INTS12 mRNA23458150
D010416PentachlorophenolPentachlorophenol results in increased expression of INTS12 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of INTS12 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of INTS12 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of INTS12 mRNA20813756
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of INTS12 mRNA21427059
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of INTS12 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of INTS12 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of INTS12 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of INTS12 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased methylation of INTS12 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of INTS12 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of INTS12 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of INTS12 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16239144  26275350  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016180snRNA processing-IDA16239144  
GO:0042795snRNA transcription by RNA polymerase II-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA23904267  
GO:0005654nucleoplasm-TAS-  
GO:0032039integrator complex-IDA16239144  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6807505RNA polymerase II transcribes snRNA genesTAS
R-HSA-6807505RNA polymerase II transcribes snRNA genesIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22461431CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (2012 Aug)Hardin MAm J Respir Cell Mol Biol