Gene: GOPC

57120
CAL|FIG|GOPC1|PIST|dJ94G16.2
golgi associated PDZ and coiled-coil motif containing
protein-coding
6q22.1
Ensembl:ENSG00000047932 MIM:606845 Vega:OTTHUMG00000015457 UniprotKB:Q9HD26
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.818e-1 (AD)  3.177e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD470.956
MARCH60.953
ATF20.952
ZDHHC170.95
WASL0.949
RHOT10.949
VPS350.947
FEM1B0.946
ZRANB20.946
CAND10.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.609
OR4F29-0.569
MTRNR2L10-0.372
KLRB1-0.365
CSAG1-0.364
MTRNR2L6-0.349
TFPI2-0.34
MTRNR2L9-0.336
FZD10-0.33
C8orf74-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GOPC mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of GOPC mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GOPC mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to GOPC protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GOPC protein]26598702
D000082AcetaminophenAcetaminophen affects the expression of GOPC mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GOPC gene27153756
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GOPC protein]26598702
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GOPC mRNA"26238291
C038328BEP protocolBEP protocol results in decreased expression of GOPC mRNA18987330
C006780bisphenol Abisphenol A affects the expression of GOPC mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GOPC mRNA29027980
C006780bisphenol Abisphenol A affects the methylation of GOPC promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of GOPC mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of GOPC mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of GOPC mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GOPC mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GOPC mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of GOPC mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GOPC mRNA"22485181
D005485FlutamideFlutamide results in increased expression of GOPC mRNA24136188
C010974glyphosateglyphosate results in increased expression of GOPC mRNA25636363
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of GOPC mRNA19376150
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GOPC mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GOPC mRNA27392435
C410337K 7174K 7174 results in increased expression of GOPC mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GOPC mRNA28001369
C051752nefazodonenefazodone results in increased expression of GOPC mRNA24136188
C016030pantogabpantogab results in decreased expression of GOPC mRNA17379144
D010269ParaquatParaquat results in increased expression of GOPC mRNA21371552
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of GOPC mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GOPC mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GOPC mRNA19429403
D010936Plant ExtractsPlant Extracts results in increased expression of GOPC mRNA23557933
C080703SK&F 83959SK&F 83959 results in increased expression of GOPC protein25852303
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GOPC mRNA21570461
C012589trichostatin Atrichostatin A results in increased expression of GOPC mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GOPC mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of GOPC mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GOPC gene25560391
D014750VincristineVincristine results in decreased expression of GOPC mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of GOPC mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11384996  11707463  12471024  19027007  20195357  25416956  
25609649  26179146  
GO:0044325ion channel binding-IPI11707463  
GO ID GO Term Qualifier Evidence PubMed
GO:0006888ER to Golgi vesicle-mediated transport-NAS11707463  
GO:0006893Golgi to plasma membrane transport-NAS11707463  
GO:0010360negative regulation of anion channel activity-IMP11707463  
GO:0015031protein transport-IEA-  
GO:0043004cytoplasmic sequestering of CFTR protein-IMP11707463  
GO:0045176apical protein localization-NAS11707463  
GO:0051260protein homooligomerization-IPI11707463  
GO:2000009negative regulation of protein localization to cell surface-IMP11707463  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005737cytoplasm-IDA11707463  
GO:0005765lysosomal membrane-TAS-  
GO:0005794Golgi apparatus-IDA11384996  
GO:0005886plasma membrane-NAS11707463  
GO:0005886plasma membrane-TAS-  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-IDA11707463  
GO:0030054cell junction-IEA-  
GO:0030140trans-Golgi network transport vesicle-IDA11707463  
GO:0030140trans-Golgi network transport vesicle-NAS11384996  
GO:0030425dendrite-IEA-  
GO:0030660Golgi-associated vesicle membrane-TAS-  
GO:0032991protein-containing complex-IDA18468998  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5627083RHO GTPases regulate CFTR traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23210427A whole blood gene expression-based signature for smoking status. (2012 Dec 3)Beineke PBMC Med Genomics