Gene: CD177

57126
HNA-2a|HNA2A|NB1|NB1 GP|PRV-1|PRV1
CD177 molecule
protein-coding
19q13.31
Ensembl:ENSG00000204936 MIM:162860 Vega:OTTHUMG00000185320 UniprotKB:Q8N6Q3
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.256e-1 (AD)  9.490e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12032655chr19:43856746CD177Promoter4.485e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MMP250.793
LILRA50.762
S100A120.742
VNN20.73
CST70.719
CXCR10.697
IL1R20.686
MMP90.677
KCNJ150.677
HK30.676

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WFDC1-0.422
ASPDH-0.39
CDT1-0.375
MAGIX-0.375
HAGHL-0.37
CORT-0.361
TM7SF2-0.355
ARSF-0.353
NTHL1-0.351
HES5-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of CD177 mRNA"27567155
D000393Air PollutantsAir Pollutants analog results in increased expression of CD177 mRNA21757418
D001151ArsenicArsenic results in increased expression of CD177 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in increased expression of CD177 mRNA20458559
C006780bisphenol Abisphenol A results in increased expression of CD177 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of CD177 mRNA25181051
D016264Dextran SulfateDextran Sulfate results in increased expression of CD177 mRNA23894361
C039281furanfuran results in increased expression of CD177 mRNA27387713
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD177 mRNA18192897
D008694MethamphetamineMethamphetamine results in increased expression of CD177 mRNA25290377
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CD177 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD177 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of CD177 mRNA18978301
C028007nickel monoxidenickel monoxide results in increased expression of CD177 mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CD177 mRNA27935865
D012822Silicon DioxideSilicon Dioxide results in increased expression of CD177 mRNA23221170
D053260SootSoot results in increased expression of CD177 mRNA22461453|2655175
C009495titanium dioxidetitanium dioxide results in increased expression of CD177 mRNA23409001|2355797
D014028Tobacco Smoke PollutionNFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution affects the expression of CD177 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CD177 mRNA20133372
D014635Valproic AcidValproic Acid results in increased expression of CD177 mRNA23527032
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CD177 gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CD177 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI17244676  28240246  
GO:0005178integrin binding-IPI21193407  28807980  
GO:0005515protein binding-IPI16189514  25416956  
GO:0048306calcium-dependent protein binding-IPI17580308  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IMP28807980  
GO:0007159leukocyte cell-cell adhesion-IMP17580308  
GO:0007596blood coagulation-TAS-  
GO:0030100regulation of endocytosis-IDA28807980  
GO:0032930positive regulation of superoxide anion generation-IGI21193407  
GO:0034394protein localization to cell surface-IMP17244676  18462208  
GO:0043312neutrophil degranulation-TAS-  
GO:0043315positive regulation of neutrophil degranulation-IGI21193407  
GO:0045087innate immune response-IEA-  
GO:0045217cell-cell junction maintenance-IMP23202369  
GO:0050900leukocyte migration-TAS-  
GO:0072672neutrophil extravasation-IMP17580308  22266279  
GO:0098742cell-cell adhesion via plasma-membrane adhesion molecules-IMP17580308  
GO:1990266neutrophil migration-IMP28807980  
GO:1990266neutrophil migrationNOTIMP28240246  
GO:2001044regulation of integrin-mediated signaling pathway-IMP28807980  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA12675722  17244676  18462208  21193407  22266279  23461681  24926686  27227454  28240246  28807980  
GO:0005886plasma membrane-TAS-  
GO:0030027lamellipodium-IEA-  
GO:0030667secretory granule membrane-IDA18462208  
GO:0031225anchored component of membrane-IEA-  
GO:0035579specific granule membrane-TAS-  
GO:0044853plasma membrane raft-IDA21193407  
GO:0070062extracellular exosome-HDA23533145  
GO:0070821tertiary granule membrane-IDA18462208  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14633783Chronic myeloproliferative disorders. (2003)Spivak JLHematology Am Soc Hematol Educ Program