Gene: RTN4

57142
ASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C
reticulon 4
protein-coding
2p16.1
Ensembl:ENSG00000115310 MIM:604475 Vega:OTTHUMG00000129337 UniprotKB:Q9NQC3
NG_029037.2
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.115e-1 (AD)  7.492e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB6A0.977
GRSF10.97
ATP6V1E10.97
REEP50.968
YWHAB0.968
KLC10.968
MKRN10.966
MATR30.966
ATP6AP20.966
PFN20.965

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.725
OR4F29-0.712
MTRNR2L10-0.363
MTRNR2L6-0.362
CSAG1-0.361
KCNJ15-0.355
CXCR2-0.351
MAGEA12-0.341
IL18RAP-0.34
MTRNR2L9-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RTN4 mRNA"22698814
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RTN4 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone affects the expression of RTN4 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RTN4 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of RTN4 protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RTN4 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of RTN4 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RTN4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RTN4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of RTN4 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of RTN4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RTN4 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of RTN4 mRNA28959563
D020106AcrylamideAcrylamide results in increased expression of RTN4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RTN4 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of RTN4 mRNA24535564
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RTN4 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of RTN4 mRNA20458559
D001280AtrazineAtrazine results in increased expression of RTN4 mRNA25929836
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNA17905399
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RTN4 mRNA21802500
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RTN4 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RTN4 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of RTN4 mRNA17912697
D004958EstradiolEstradiol results in decreased expression of RTN4 mRNA19484750
C095105bexarotenebexarotene results in increased expression of RTN4 mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of RTN4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of RTN4 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of RTN4 protein28903499
C584509C646 compoundC646 compound results in decreased expression of RTN4 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of RTN4 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RTN4 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of RTN4 mRNA23650126
C100187chloropicrinchloropicrin results in decreased expression of RTN4 mRNA26352163
D004390ChlorpyrifosChlorpyrifos results in decreased expression of RTN4 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RTN4 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RTN4 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of RTN4 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of RTN4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RTN4 mRNA]17585979
D003024ClozapineClozapine results in increased expression of RTN4 mRNA17266109
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of RTN4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of RTN4 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of RTN4 mRNA25562108
D013759DronabinolDronabinol results in decreased expression of RTN4 mRNA17578508
D003976DiazinonDiazinon affects the expression of RTN4 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RTN4 mRNA17361019|2126653
D002945CisplatinCisplatin results in decreased expression of RTN4 mRNA21151649
D004026DieldrinDieldrin affects the expression of RTN4 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of RTN4 mRNA15238619
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RTN4 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RTN4 mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RTN4 mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of RTN4 mRNA25380136
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RTN4 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RTN4 mRNA26865667
D005419FlavonoidsFlavonoids results in decreased expression of RTN4 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of RTN4 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RTN4 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RTN4 mRNA20938992
C039281furanfuran results in increased expression of RTN4 mRNA26194646
D019833GenisteinGenistein results in increased expression of RTN4 mRNA26865667
D006046Gold[Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA19695318
D006220HaloperidolHaloperidol results in decreased expression of RTN4 mRNA18797397
C492448ICG 001ICG 001 results in decreased expression of RTN4 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RTN4 mRNA25613284
D007657Ketone BodiesKetone Bodies results in increased expression of RTN4 mRNA16807920
D007854LeadLead affects the splicing of RTN4 mRNA28903495
D007854LeadLead results in decreased expression of RTN4 mRNA22313790
C008261lead acetatelead acetate affects the expression of RTN4 mRNA21864555
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of RTN4 mRNA"24972896
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RTN4 mRNA21641980
D008344Maneb[Maneb co-treated with Paraquat] results in increased expression of RTN4 mRNA23017109
C025340manganese chloridemanganese chloride results in increased expression of RTN4 mRNA17467022
D008628MercuryMercury results in decreased expression of RTN4 mRNA19937285
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RTN4 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RTN4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RTN4 mRNA28001369
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNA17905399
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RTN4 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of RTN4 protein26648565
D0156551-Methyl-4-phenylpyridiniumRTN4 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MTOR protein]26648565
D0156551-Methyl-4-phenylpyridiniumRTN4 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RTN4R protein]26648565
D0156551-Methyl-4-phenylpyridiniumRTN4 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of STAT3 protein]26648565
D0156551-Methyl-4-phenylpyridiniumSirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RTN4 protein]26648565
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RTN4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RTN4 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of RTN4 mRNA25380136
C022838nickel chloridenickel chloride affects the expression of RTN4 mRNA22546817
C017557nickel subsulfidenickel subsulfide results in increased expression of RTN4 mRNA21086188
C007350nitrofennitrofen results in decreased expression of RTN4 mRNA20638522
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of RTN4 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of RTN4 mRNA20971185
C076029olanzapineolanzapine results in decreased expression of RTN4 mRNA18797397
C507134ON 01910ON 01910 affects the expression of RTN4 mRNA22351695
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RTN4 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of RTN4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of RTN4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RTN4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RTN4 mRNA]17655762
D010269Paraquat[Maneb co-treated with Paraquat] results in increased expression of RTN4 mRNA23017109
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of RTN4 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of RTN4 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RTN4 mRNA]17655762
D052638Particulate MatterParticulate Matter results in decreased expression of RTN4 mRNA28341207
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RTN4 mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of RTN4 mRNA16221955
D010622PhencyclidinePhencyclidine results in increased expression of RTN4 mRNA17266109
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RTN4 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of RTN4 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RTN4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RTN4 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of RTN4 mRNA17426115|1830175
C006253pirinixic acidpirinixic acid results in increased expression of RTN4 mRNA22484513
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA19695318
C045950propiconazolepropiconazole results in decreased expression of RTN4 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of RTN4 mRNA24780913
D011748PyrogallolPyrogallol results in increased expression of RTN4 mRNA20362636
D012834SilverSilver results in increased expression of RTN4 mRNA26551752
D020123SirolimusSirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RTN4 protein]26648565
C009277sodium arsenatesodium arsenate results in increased expression of RTN4 mRNA21795629
C016104sodium bichromatesodium bichromate results in increased expression of RTN4 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of RTN4 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of RTN4 mRNA18175754
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RTN4 mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of RTN4 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of RTN4 mRNA17555576
D013629TamoxifenTamoxifen results in decreased expression of RTN4 mRNA19457130
D013739TestosteroneTestosterone results in decreased expression of RTN4 mRNA20600201|2166921
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of RTN4 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RTN4 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RTN4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RTN4 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RTN4 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RTN4 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of RTN4 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased expression of RTN4 mRNA25549359
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNA17905399
C012589trichostatin Atrichostatin A results in increased expression of RTN4 mRNA24935251
D014520UrethaneUrethane results in increased expression of RTN4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RTN4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RTN4 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of RTN4 mRNA24535564
D014640VancomycinVancomycin results in decreased expression of RTN4 mRNA18930951
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of RTN4 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of RTN4 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of RTN4 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RTN4 gene25560391
C025643vinclozolinvinclozolin affects the expression of RTN4 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of RTN4 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI11126360  16752908  19665976  21516116  25416956  26906412  
GO:0031625ubiquitin protein ligase binding-IPI27353365  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0006915apoptotic process-NAS11126360  
GO:0007409axonogenesis-IBA21873635  
GO:0007413axonal fasciculation-IBA21873635  
GO:0007413axonal fasciculation-ISS-  
GO:0010634positive regulation of epithelial cell migration-IMP27353365  
GO:0021801cerebral cortex radial glia guided migration-ISS-  
GO:0030308negative regulation of cell growth-IMP20463223  
GO:0030517negative regulation of axon extension-IDA10667797  
GO:0033601positive regulation of mammary gland epithelial cell proliferation-IMP27353365  
GO:0042981regulation of apoptotic process-NAS11126360  
GO:0048694positive regulation of collateral sprouting of injured axon-IEA-  
GO:0050771negative regulation of axonogenesis-TAS-  
GO:0050821protein stabilization-IMP27353365  
GO:0051292nuclear pore complex assembly-IMP26906412  
GO:0051897positive regulation of protein kinase B signaling-IMP27353365  
GO:0060317cardiac epithelial to mesenchymal transition-IEA-  
GO:0071277cellular response to calcium ion-HEP21237226  
GO:0071786endoplasmic reticulum tubular network organization-IMP18779370  26906412  
GO:0071787endoplasmic reticulum tubular network formation-IDA24262037  25612671  
GO:1903860negative regulation of dendrite extension-IEA-  
GO:1905552positive regulation of protein localization to endoplasmic reticulum-IDA27353365  
GO:1905580positive regulation of ERBB3 signaling pathway-IMP27353365  
GO:1905943negative regulation of formation of growth cone in injured axon-IEA-  
GO:1990809endoplasmic reticulum tubular network membrane organization-IMP27619977  
GO:2000172regulation of branching morphogenesis of a nerve-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IMP14644040  
GO:0005635nuclear envelope-IDA11126360  
GO:0005783endoplasmic reticulum-HDA16791210  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005783endoplasmic reticulum-NAS11126360  
GO:0005789endoplasmic reticulum membrane-IDA25612671  26906412  
GO:0005886plasma membrane-TAS-  
GO:0014069postsynaptic density-IEA-  
GO:0030176integral component of endoplasmic reticulum membrane-IDA10667797  
GO:0043025neuronal cell body-IEA-  
GO:0044294dendritic growth cone-IEA-  
GO:0071782endoplasmic reticulum tubular network-IDA27353365  
GO:0098826endoplasmic reticulum tubular network membrane-IDA27619977  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193634Axonal growth inhibition (RHOA activation)TAS
R-HSA-193697p75NTR regulates axonogenesisTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29437267Pharmacoproteomics Profile in Response to Acamprosate Treatment of an Alcoholism Animal Model. (2018 Apr)Germany CEProteomics