Gene: PSMD9

5715
Rpn4|p27
proteasome 26S subunit, non-ATPase 9
protein-coding
12q24.31
Ensembl:ENSG00000110801 MIM:603146 Vega:OTTHUMG00000168945 UniprotKB:O00233
NC_000012.12
PubMed|SNP Mapped
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.821e-1 (AD)  7.172e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2230681chr12:121888906 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMB10.928
SAP30BP0.924
RNF1810.923
TALDO10.918
CWC150.912
MRPL200.908
SNRPC0.905
CNPY20.904
NELFE0.901
MPDU10.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.721
OR4F29-0.682
MTRNR2L6-0.268
MTRNR2L9-0.259
P2RY14-0.227
C8orf74-0.21
HMHB1-0.204
RNF223-0.201
KRT73-0.198
TTLL10-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PSMD9 mRNA"19114083
D000082AcetaminophenAcetaminophen affects the expression of PSMD9 mRNA17562736
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of PSMD9 protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PSMD9 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of PSMD9 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSMD9 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of PSMD9 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PSMD9 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PSMD9 gene28505145
D002922CiguatoxinsCiguatoxins affects the expression of PSMD9 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of PSMD9 mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of PSMD9 mRNA19549813
D004008DiclofenacDiclofenac results in decreased expression of PSMD9 mRNA26934552
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PSMD9 mRNA24535843
D004178DiquatDiquat affects the expression of PSMD9 mRNA22814884
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PSMD9 protein23301498
D018120FinasterideFinasteride results in increased expression of PSMD9 mRNA24136188
D005485FlutamideFlutamide results in increased expression of PSMD9 mRNA24136188
D005839GentamicinsGentamicins results in decreased expression of PSMD9 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of PSMD9 mRNA22061828
C018584linaloollinalool results in increased expression of PSMD9 mRNA26703569
D008627Mercuric ChlorideMercuric Chloride affects the expression of PSMD9 mRNA20353558
D008727MethotrexateMethotrexate results in decreased expression of PSMD9 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PSMD9 mRNA17961207|2345815
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PSMD9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PSMD9 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of PSMD9 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PSMD9 mRNA17616710
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PSMD9 mRNA24535843
D010695PhlorhizinPhlorhizin results in decreased expression of PSMD9 mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of PSMD9 mRNA23811191
D012822Silicon DioxideSilicon Dioxide results in increased expression of PSMD9 mRNA25351596
D013605T-2 ToxinT-2 Toxin results in increased expression of PSMD9 mRNA26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSMD9 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PSMD9 mRNA21215274
D019284ThapsigarginThapsigargin results in decreased expression of PSMD9 protein24648495
D014635Valproic AcidValproic Acid results in increased expression of PSMD9 mRNA23179753
D015032ZincZinc deficiency results in increased expression of PSMD9 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-ISS10567574  
GO:0005515protein binding-IPI16189514  19490896  21516116  25009770  25416956  
GO:0043425bHLH transcription factor binding-ISS10567574  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-NAS9653651  
GO:0016579protein deubiquitination-TAS-  
GO:0032024positive regulation of insulin secretion-ISS10567574  
GO:0043687post-translational protein modification-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS10567574  16293776  
GO:0046676negative regulation of insulin secretion-ISS16099819  
GO:0070682proteasome regulatory particle assembly-IBA21873635  
GO:0070682proteasome regulatory particle assembly-IMP19490896  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS10567574  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005838proteasome regulatory particle-NAS9653651  
GO:0008540proteasome regulatory particle, base subcomplex-IBA21873635  
GO:0008540proteasome regulatory particle, base subcomplexcolocalizes_withIDA19490896  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1169091Activation of NF-kappaB in B cellsTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1236974ER-Phagosome pathwayIEA
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1236975Antigen processing-Cross presentationIEA
R-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)TAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-169911Regulation of ApoptosisIEA
R-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/CTAS
R-HSA-174113SCF-beta-TrCP mediated degradation of Emi1TAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174154APC/C:Cdc20 mediated degradation of SecurinTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-180534Vpu mediated degradation of CD4TAS
R-HSA-180585Vif-mediated degradation of APOBEC3GTAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-211733Regulation of activated PAK-2p34 by proteasome mediated degradationIEA
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2871837FCERI mediated NF-kB activationTAS
R-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1TAS
R-HSA-350562Regulation of ornithine decarboxylase (ODC)TAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-422475Axon guidanceIEA
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-4608870Asymmetric localization of PCP proteinsTAS
R-HSA-4641257Degradation of AXINTAS
R-HSA-4641258Degradation of DVLTAS
R-HSA-5357801Programmed Cell DeathIEA
R-HSA-5358346Hedgehog ligand biogenesisTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERADTAS
R-HSA-5387390Hh mutants abrogate ligand secretionTAS
R-HSA-5607761Dectin-1 mediated noncanonical NF-kB signalingTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5610780Degradation of GLI1 by the proteasomeTAS
R-HSA-5610783Degradation of GLI2 by the proteasomeIEA
R-HSA-5610785GLI3 is processed to GLI3R by the proteasomeTAS
R-HSA-5610787Hedgehog 'off' stateIEA
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5676590NIK-->noncanonical NF-kB signalingTAS
R-HSA-5678895Defective CFTR causes cystic fibrosisTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-68827CDT1 association with the CDC6:ORC:origin complexTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69229Ubiquitin-dependent degradation of Cyclin D1TAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69541Stabilization of p53TAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25ATAS
R-HSA-69610p53-Independent DNA Damage ResponseTAS
R-HSA-69613p53-Independent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75815Ubiquitin-dependent degradation of Cyclin DTAS
R-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointTAS
R-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosisTAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8939902Regulation of RUNX2 expression and activityTAS
R-HSA-8941858Regulation of RUNX3 expression and activityTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-8951664NeddylationTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22449891Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. (2012 Jun)Wong MLMol Psychiatry