Gene: SLURP1

57152
ANUP|ARS|ArsB|LY6LS|MDM
secreted LY6/PLAUR domain containing 1
protein-coding
8q24.3
Ensembl:ENSG00000126233 MIM:606119 Vega:OTTHUMG00000164685 UniprotKB:P55000
NG_011494.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.293e-1 (AD)  7.644e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINB50.716
KLK110.688
KRT160.667
NCCRP10.667
LAD10.661
SCNN1B0.655
FOXE10.643
ALDH3B20.642
KRT6B0.641
KRT140.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCLY-0.282
PNPO-0.28
NRG2-0.272
B3GALT4-0.272
CLCN2-0.271
PLA2G6-0.271
SLC35E2B-0.269
ATG2A-0.269
ZNF500-0.268
FBXO15-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000109Acetylcholinemethyllycaconitine inhibits the reaction [SLURP1 protein results in increased abundance of Acetylcholine]24365495
D000109AcetylcholineSLURP1 protein results in increased abundance of Acetylcholine24365495
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLURP1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLURP1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SLURP1 promoter]19654925
D004958EstradiolEstradiol results in increased expression of SLURP1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of SLURP1 mRNA25181051
D003300CopperCopper deficiency results in increased expression of SLURP1 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of SLURP1 mRNA27523638
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SLURP1 mRNA28962523
D019422Dietary SucroseDietary Sucrose results in increased expression of SLURP1 mRNA26033743
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLURP1 mRNA17555576
D005557FormaldehydeFormaldehyde results in increased expression of SLURP1 mRNA20884683
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [SLURP1 protein results in increased abundance of Acetylcholine]24365495
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [SLURP1 protein results in increased expression of CHAT]24365495
D009602NitrosaminesNitrosamines results in decreased expression of SLURP1 mRNA17280689
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of SLURP1 mRNA17616710
D013629TamoxifenTamoxifen affects the expression of SLURP1 mRNA17555576
D014635Valproic AcidValproic Acid results in increased methylation of SLURP1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SLURP1 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-NAS8742060  
GO:0005515protein binding-IPI26905431  
GO:0030549acetylcholine receptor activator activity-IDA14506129  
GO ID GO Term Qualifier Evidence PubMed
GO:0001775cell activation-NAS11285253  
GO:0007155cell adhesion-TAS14506129  
GO:0007626locomotory behavior-IEA-  
GO:0008285negative regulation of cell proliferation-IDA25168896  
GO:0010839negative regulation of keratinocyte proliferation-IEA-  
GO:0030336negative regulation of cell migration-IDA25168896  
GO:0038195urokinase plasminogen activator signaling pathway-IDA25168896  
GO:0050884neuromuscular process controlling posture-IEA-  
GO:2000273positive regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS8742060  14721776  
GO:0005615extracellular space-IDA25919322  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29545933Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer. (2018 Feb 20)Throm VMOncotarget