Gene: TMEM63C

57156
C14orf171|CSC1|hsCSC1
transmembrane protein 63C
protein-coding
14q24.3
Ensembl:ENSG00000165548 Vega:OTTHUMG00000171557 UniprotKB:Q9P1W3
NC_000014.9
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.156e-1 (AD)  1.331e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2287386chr14:77252278 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP3B20.934
UBE2O0.934
CELSR30.927
SYT70.921
UNC5A0.919
CACNA1B0.918
SGSM10.918
PRRG30.918
CAMKK10.917
TRO0.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.532
YES1-0.524
HEY2-0.506
REST-0.484
MBNL3-0.481
NXT2-0.477
COPZ2-0.476
LRAT-0.47
ASB4-0.461
CNN2-0.46

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TMEM63C mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TMEM63C gene27153756
D000447AldehydesAldehydes results in increased expression of TMEM63C mRNA25014914
D001151ArsenicArsenic affects the methylation of TMEM63C gene25304211
D001280AtrazineAtrazine results in decreased expression of TMEM63C mRNA25929836
C547126AZM551248AZM551248 results in increased expression of TMEM63C mRNA22323515
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of TMEM63C mRNA26496021
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of TMEM63C mRNA26945725
C006780bisphenol Abisphenol A results in decreased expression of TMEM63C mRNA26364221
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of TMEM63C mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TMEM63C mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TMEM63C mRNA26079696
D002509CephaloridineCephaloridine results in increased expression of TMEM63C mRNA18500788
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TMEM63C mRNA17557909
C046012pentanalpentanal results in increased expression of TMEM63C mRNA26079696
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of TMEM63C mRNA26945725
C005556propionaldehydepropionaldehyde results in increased expression of TMEM63C mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of TMEM63C mRNA27029645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM63C mRNA21570461
D014635Valproic AcidValproic Acid affects the expression of TMEM63C mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TMEM63C mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of TMEM63C gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005227calcium activated cation channel activity-IDA24503647  
GO ID GO Term Qualifier Evidence PubMed
GO:0006812cation transport-IDA24503647  
GO:0034220ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal