Gene: JPH2

57158
CMH17|JP-2|JP2
junctophilin 2
protein-coding
20q13.12
Ensembl:ENSG00000149596 MIM:605267 Vega:OTTHUMG00000033037 UniprotKB:Q9BR39
NG_031867.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.223e-1 (AD)  5.476e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2017246chr20:44147203 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNMB10.866
PLN0.811
TRABD2B0.806
GATA60.797
CDC20B0.786
OR51E10.785
ALX40.773
SLC13A40.772
SLC22A80.769
AOC30.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAIAP2L2-0.305
CA7-0.301
FEZF2-0.298
RTN4R-0.295
YBX2-0.291
CACNA1I-0.286
CHRM1-0.285
RS1-0.284
ABCC12-0.283
MYADML2-0.282

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of JPH2 mRNA"20453058
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of JPH2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JPH2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JPH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JPH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JPH2 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of JPH2 mRNA28959563
C006632arsenic trioxidearsenic trioxide results in increased expression of JPH2 mRNA20458559
D001280AtrazineAtrazine results in increased expression of JPH2 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JPH2 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of JPH2 mRNA21786754
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of JPH2 mRNA17484886
C043211carvedilolcarvedilol results in increased expression of JPH2 protein22375019
D003300CopperCopper deficiency results in increased expression of JPH2 mRNA26033743
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of JPH2 mRNA24317228
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of JPH2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of JPH2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of JPH2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of JPH2 mRNA18042831
D004237DiuronDiuron results in increased expression of JPH2 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of JPH2 mRNA19915844
D004317DoxorubicinRazoxane inhibits the reaction [Doxorubicin results in increased expression of JPH2 mRNA]19915844
C412815GW 4064GW 4064 results in increased expression of JPH2 mRNA26655953
D007213IndomethacinIndomethacin results in increased expression of JPH2 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of JPH2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of JPH2 mRNA27432991
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of JPH2 mRNA26644586
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of JPH2 mRNA26011545
D008790MetoprololMetoprolol results in increased expression of JPH2 protein22375019
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of JPH2 protein24625837
D009532NickelNickel results in decreased expression of JPH2 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of JPH2 mRNA27935865
D000073878Palm OilPalm Oil results in decreased expression of JPH2 mRNA18042831
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JPH2 mRNA"27188386
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of JPH2 mRNA27935865
D011192Potassium DichromatePotassium Dichromate results in decreased expression of JPH2 mRNA23608068
C513428pyrachlostrobinpyrachlostrobin results in increased expression of JPH2 mRNA27029645
D011929RazoxaneRazoxane inhibits the reaction [Doxorubicin results in increased expression of JPH2 mRNA]19915844
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of JPH2 mRNA25895662
D012834SilverSilver results in increased expression of JPH2 mRNA28959546
C009277sodium arsenatesodium arsenate results in decreased expression of JPH2 mRNA21795629
C016104sodium bichromatesodium bichromate results in decreased expression of JPH2 mRNA22155349
C009495titanium dioxidetitanium dioxide results in decreased expression of JPH2 mRNA23557971
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JPH2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of JPH2 mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of JPH2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IDA24001019  
GO:0005515protein binding-IPI20095964  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IDA24001019  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-IDA24001019  
GO:0010314phosphatidylinositol-5-phosphate binding-IDA24001019  
GO:0015278calcium-release channel activity-IBA21873635  
GO:0015278calcium-release channel activity-IDA20095964  
GO:0032266phosphatidylinositol-3-phosphate binding-IDA24001019  
GO:0070273phosphatidylinositol-4-phosphate binding-IDA24001019  
GO:0070300phosphatidic acid binding-IDA24001019  
GO:0080025phosphatidylinositol-3,5-bisphosphate binding-IDA24001019  
GO ID GO Term Qualifier Evidence PubMed
GO:0051209release of sequestered calcium ion into cytosol-IEA-  
GO:0055024regulation of cardiac muscle tissue development-IEA-  
GO:0055074calcium ion homeostasis-IDA20095964  
GO:0060314regulation of ryanodine-sensitive calcium-release channel activity-TAS19095005  
GO:0060316positive regulation of ryanodine-sensitive calcium-release channel activity-IDA20095964  
GO:0060402calcium ion transport into cytosol-TAS19095005  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0014701junctional sarcoplasmic reticulum membrane-TAS19095005  
GO:0016021integral component of membrane-IEA-  
GO:0016529sarcoplasmic reticulum-IBA21873635  
GO:0030018Z disc-IEA-  
GO:0030314junctional membrane complex-IBA21873635  
GO:0030314junctional membrane complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal