Gene: PSMD10

5716
dJ889N15.2|p28|p28(GANK)
proteasome 26S subunit, non-ATPase 10
protein-coding
Xq22.3
Ensembl:ENSG00000101843 MIM:300880 Vega:OTTHUMG00000022177 UniprotKB:O75832
NG_012521.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WRB0.95
MFF0.947
VAPA0.94
COA50.94
TSN0.939
GABARAPL20.937
DPY300.937
VBP10.936
POLR2K0.936
CWC150.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.824
OR4F29-0.783
C8orf74-0.225
MTRNR2L6-0.223
IFNG-0.217
MTRNR2L10-0.21
TTLL10-0.209
OR6C74-0.208
KLRB1-0.208
MTRNR2L3-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PSMD10 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PSMD10 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PSMD10 mRNA27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSMD10 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PSMD10 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of PSMD10 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PSMD10 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PSMD10 mRNA18804290
C018021cobaltous chloridecobaltous chloride results in increased expression of PSMD10 mRNA24612858
D019327Copper SulfateCopper Sulfate results in decreased expression of PSMD10 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PSMD10 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PSMD10 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of PSMD10 mRNA28302478
C024629dimethyl phthalatedimethyl phthalate affects the expression of PSMD10 mRNA26924002
D004317DoxorubicinPSMD10 results in decreased susceptibility to Doxorubicin21287809
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PSMD10 protein23301498
C007738fluoranthenefluoranthene results in decreased expression of PSMD10 mRNA18522720
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of PSMD10 protein16448463
D0150732-AcetylaminofluoreneRB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]16448463
D019833GenisteinGenistein results in increased methylation of PSMD10 gene28505145
D017313FenretinideFenretinide results in increased expression of PSMD10 mRNA28973697
C063855microcystin RRmicrocystin RR results in decreased expression of PSMD10 protein19111056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PSMD10 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PSMD10 mRNA"25554681
D010695PhlorhizinPhlorhizin results in decreased expression of PSMD10 mRNA22538082
C059514resveratrolresveratrol results in increased expression of PSMD10 protein25505154
C017947sodium arsenitesodium arsenite affects the expression of PSMD10 mRNA29319823
D013629TamoxifenTamoxifen results in decreased expression of PSMD10 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSMD10 mRNA21570461
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of PSMD10 gene27618143

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10613832  11900540  12525503  16023600  16189514  17003112  
17353931  19490896  19615732  21988832  24338975  25416956  
26496610  26972000  
GO:0008134transcription factor binding-IPI18040287  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA16023600  
GO:0006915apoptotic process-IEA-  
GO:0007253cytoplasmic sequestering of NF-kappaB-IDA18040287  
GO:0016579protein deubiquitination-TAS-  
GO:0030307positive regulation of cell growth-IDA10613832  
GO:0031398positive regulation of protein ubiquitination-IMP16023600  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA18040287  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IDA16023600  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-TAS10613832  
GO:0043066negative regulation of apoptotic process-IDA16023600  
GO:0043066negative regulation of apoptotic process-IMP19729910  
GO:0043409negative regulation of MAPK cascade-IMP19729910  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-IDA16023600  
GO:0043687post-translational protein modification-TAS-  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IDA11900540  
GO:0070682proteasome regulatory particle assembly-IMP19490896  
GO:0090201negative regulation of release of cytochrome c from mitochondria-IMP19729910  
GO ID GO Term Qualifier Evidence PubMed
GO:0000502proteasome complex-IDA17323924  
GO:0005634nucleus-IDA18040287  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA18040287  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005838proteasome regulatory particle-TAS9714768  
GO:0008540proteasome regulatory particle, base subcomplexcolocalizes_withIDA19490896  
GO:0045111intermediate filament cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1169091Activation of NF-kappaB in B cellsTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1236974ER-Phagosome pathwayIEA
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1236975Antigen processing-Cross presentationIEA
R-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)TAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-169911Regulation of ApoptosisIEA
R-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/CTAS
R-HSA-174113SCF-beta-TrCP mediated degradation of Emi1TAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174154APC/C:Cdc20 mediated degradation of SecurinTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-180534Vpu mediated degradation of CD4TAS
R-HSA-180585Vif-mediated degradation of APOBEC3GTAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-211733Regulation of activated PAK-2p34 by proteasome mediated degradationIEA
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2871837FCERI mediated NF-kB activationTAS
R-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1TAS
R-HSA-350562Regulation of ornithine decarboxylase (ODC)TAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-422475Axon guidanceIEA
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-4608870Asymmetric localization of PCP proteinsTAS
R-HSA-4641257Degradation of AXINTAS
R-HSA-4641258Degradation of DVLTAS
R-HSA-5357801Programmed Cell DeathIEA
R-HSA-5358346Hedgehog ligand biogenesisTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERADTAS
R-HSA-5387390Hh mutants abrogate ligand secretionTAS
R-HSA-5607761Dectin-1 mediated noncanonical NF-kB signalingTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5610780Degradation of GLI1 by the proteasomeTAS
R-HSA-5610783Degradation of GLI2 by the proteasomeIEA
R-HSA-5610785GLI3 is processed to GLI3R by the proteasomeTAS
R-HSA-5610787Hedgehog 'off' stateIEA
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5676590NIK-->noncanonical NF-kB signalingTAS
R-HSA-5678895Defective CFTR causes cystic fibrosisTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-68827CDT1 association with the CDC6:ORC:origin complexTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69229Ubiquitin-dependent degradation of Cyclin D1TAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69541Stabilization of p53TAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25ATAS
R-HSA-69610p53-Independent DNA Damage ResponseTAS
R-HSA-69613p53-Independent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75815Ubiquitin-dependent degradation of Cyclin DTAS
R-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointTAS
R-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosisTAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8939902Regulation of RUNX2 expression and activityTAS
R-HSA-8941858Regulation of RUNX3 expression and activityTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-8951664NeddylationTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26394032Association between functional PSMD10 Rs111638916 variant regulated by MiR-505 and gastric cancer risk in a Chinese population. (2015)Liu YCell Physiol Biochem