Gene: SALL4

57167
DRRS|HSAL4|ZNF797
spalt like transcription factor 4
protein-coding
20q13.2
Ensembl:ENSG00000101115 MIM:607343 Vega:OTTHUMG00000032752 UniprotKB:Q9UJQ4
NG_008000.1
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.516e-1 (AD)  4.629e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL15A10.633
MROH50.63
TRPC40.62
DPPA40.615
FOLR30.614
NMUR10.608
PLEKHG20.606
TFPI20.6
RNF170.592
PARP150.592

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf53-0.404
ASPDH-0.317
B3GALT1-0.315
THY1-0.3
NDP-0.299
KCNA2-0.29
KCNJ6-0.289
PARD6A-0.289
CA7-0.288
TMEM221-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SALL4 mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SALL4 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SALL4 mRNA26690555
D001374AzacitidineAzacitidine affects the methylation of SALL4 promoter17546590
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SALL4 promoter]19654925
D004958EstradiolEstradiol results in decreased expression of SALL4 mRNA19167446
C006780bisphenol Abisphenol A affects the expression of SALL4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SALL4 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of SALL4 mRNA23798566
C006780bisphenol Abisphenol A results in decreased expression of SALL4 mRNA25181051
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SALL4 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of SALL4 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of SALL4 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of SALL4 mRNA27989131
D002945CisplatinCisplatin results in increased phosphorylation of SALL4 protein22006019
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SALL4 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of SALL4 mRNA25016146
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SALL4 mRNA26846883
D007854LeadLead affects the expression of SALL4 mRNA28903495
C008261lead acetatelead acetate results in increased expression of SALL4 mRNA22609695
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SALL4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SALL4 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SALL4 mRNA26924002
D010100OxygenOxygen deficiency results in increased expression of SALL4 mRNA26516004
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SALL4 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SALL4 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of SALL4 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of SALL4 mRNA26079696
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of SALL4 mRNA19167446
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of SALL4 mRNA21427059
D013849ThimerosalThimerosal results in decreased expression of SALL4 mRNA27188386
D014212TretinoinTretinoin results in decreased expression of SALL4 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SALL4 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SALL4 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SALL4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SALL4 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of SALL4 mRNA19136453|2054688
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SALL4 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI21914818  
GO:0008134transcription factor binding-IEA-  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001833inner cell mass cell proliferation-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0003281ventricular septum development-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0007275multicellular organism development-IBA21873635  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0035019somatic stem cell population maintenance-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000792heterochromatin-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0032991protein-containing complex-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-2892247POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationTAS
R-HSA-452723Transcriptional regulation of pluripotent stem cellsTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29785018Pulmonary adenocarcinoma with high-grade fetal adenocarcinoma component has a poor prognosis, comparable to that of micropapillary adenocarcinoma. (2018 May 21)Suzuki MMod Pathol
29416638Nicotine-enhanced stemness and epithelial-mesenchymal transition of human umbilical cord mesenchymal stem cells promote tumor formation and growth in nude mice. (2018 Jan 2)Li TOncotarget
28256572Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities. (2017 Jun)Yoshida AMod Pathol
26333835Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration. (2015 Dec)Scheinfeldt LBAm J Med Genet B Neuropsychiatr Genet