Gene: KIAA1191

57179
p33MONOX|p60MONOX
KIAA1191
protein-coding
5q35.2
Ensembl:ENSG00000122203 Vega:OTTHUMG00000130656 UniprotKB:Q96A73
NC_000005.10
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.832e-1 (AD)  6.827e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10063877chr5:176357917 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11134974chr5:176354956 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3749804chr5:176349152 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNRNPH20.948
GHITM0.946
RAB1A0.945
MAP1LC3B0.943
ARF10.942
APLP20.941
RAB7A0.941
ARL6IP10.941
EIF4H0.939
PRNP0.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.841
OR4F29-0.794
MTRNR2L6-0.249
OR6C74-0.247
SH2D1A-0.225
KLRB1-0.222
KLRK1-0.22
MTRNR2L10-0.218
CTNNA3-0.217
MTRNR2L9-0.216

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1191 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1191 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of KIAA1191 mRNA22230336
C006780bisphenol Abisphenol A results in increased expression of KIAA1191 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of KIAA1191 protein28903499
D003375CoumestrolCoumestrol results in decreased expression of KIAA1191 mRNA19167446
D003976DiazinonDiazinon results in increased methylation of KIAA1191 gene22964155
D007854LeadLead affects the splicing of KIAA1191 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of KIAA1191 mRNA"24972896
D010936Plant ExtractsPlant Extracts results in increased expression of KIAA1191 mRNA23557933
C012589trichostatin Atrichostatin A affects the expression of KIAA1191 mRNA28542535
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1191 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KIAA1191 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KIAA1191 mRNA23179753|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI21044950  
GO:0016491oxidoreductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005737cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal