Gene: ATP10D

57205
ATPVD
ATPase phospholipid transporting 10D (putative)
protein-coding
4p12
Ensembl:ENSG00000145246 Vega:OTTHUMG00000160784 UniprotKB:Q9P241
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.395e-1 (AD)  4.707e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMC10.861
LPP0.86
CFLAR0.854
TEP10.852
BNIP20.849
AFF10.833
TRAM10.831
CD2AP0.827
ROCK10.822
DENND4C0.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSG1-0.405
ABCC12-0.394
PIP5KL1-0.393
C2CD4D-0.388
SLC7A4-0.381
DRD5-0.378
HAS1-0.377
BHLHA9-0.376
LYPD8-0.376
CRH-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ATP10D mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ATP10D mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ATP10D mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of ATP10D mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ATP10D mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ATP10D mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ATP10D gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATP10D mRNA22228805|2719552
C006780bisphenol Abisphenol A results in increased expression of ATP10D mRNA25594700
C006780bisphenol Abisphenol A affects the expression of ATP10D mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP10D mRNA20938992
D016572CyclosporineCyclosporine results in decreased expression of ATP10D mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of ATP10D mRNA20106945
D003561CytarabineCytarabine results in increased expression of ATP10D mRNA19194470
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ATP10D mRNA]27941970
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ATP10D mRNA28962523
D002945CisplatinCisplatin results in decreased expression of ATP10D mRNA22023808
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ATP10D mRNA17005392
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ATP10D mRNA25380136
D004237DiuronDiuron results in increased expression of ATP10D mRNA21551480
C118739entinostatentinostat results in increased expression of ATP10D mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATP10D mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATP10D mRNA17557909
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP10D mRNA20938992
C000625835HFPO2 compoundHFPO2 compound results in increased expression of ATP10D mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of ATP10D mRNA27553808
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ATP10D mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of ATP10D mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ATP10D mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ATP10D mRNA24796395
C042720mercuric bromidemercuric bromide results in increased expression of ATP10D mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP10D mRNA20938992
C016030pantogabpantogab results in increased expression of ATP10D mRNA17379144
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of ATP10D mRNA26678675
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ATP10D mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of ATP10D mRNA18301758|2081375
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATP10D mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ATP10D mRNA22079256|2271453
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ATP10D mRNA28903501
D012643SeleniumSelenium results in decreased expression of ATP10D mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of ATP10D mRNA23221170
D012834SilverSilver results in decreased expression of ATP10D mRNA27131904
D053260SootSoot results in increased expression of ATP10D mRNA26551751
C501413tesaglitazartesaglitazar results in increased expression of ATP10D mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATP10D mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ATP10D mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of ATP10D mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ATP10D mRNA19969065
D014212TretinoinTretinoin results in increased expression of ATP10D mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of ATP10D mRNA25549359
C012589trichostatin Atrichostatin A results in increased expression of ATP10D mRNA24935251
D014520UrethaneUrethane results in increased expression of ATP10D mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10D mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ATP10D mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ATP10D mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ATP10D mRNA17292431
D014638VanadatesVanadates results in increased expression of ATP10D mRNA22714537
C111237vorinostatvorinostat results in increased expression of ATP10D mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-NAS12532265  
GO:0004012phospholipid-translocating ATPase activity-IBA21873635  
GO:0004012phospholipid-translocating ATPase activity-NAS12532265  
GO:0004012phospholipid-translocating ATPase activity-TAS-  
GO:0005515protein binding-IPI21914794  
GO:0005524ATP binding-NAS12532265  
GO ID GO Term Qualifier Evidence PubMed
GO:0006812cation transport-NAS12532265  
GO:0034220ion transmembrane transport-TAS-  
GO:0045332phospholipid translocation-IBA21873635  
GO:0045332phospholipid translocation-NAS21914794  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005783endoplasmic reticulum-IDA21914794  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-NAS12532265  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24125428A gene variant in the Atp10d gene associates with atherosclerotic indices in Japanese elderly population. (2013 Nov)Kengia JTAtherosclerosis