Gene: CEMIP

57214
CCSP1|HYBID|KIAA1199|TMEM2L
cell migration inducing hyaluronidase 1
protein-coding
15q25.1
Ensembl:ENSG00000103888 MIM:608366 Vega:OTTHUMG00000144184 UniprotKB:Q8WUJ3
NC_000015.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.081e-1 (AD)  4.439e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12591074chr15:80845525 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12372944chr15:80843108 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEMIP mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of CEMIP mRNA"19095052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CEMIP mRNA"23146750
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of CEMIP mRNA"21920950
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEMIP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CEMIP mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEMIP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEMIP mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEMIP mRNA"25510870
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of CEMIP mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of CEMIP mRNA22230336|2906747
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CEMIP gene27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of CEMIP mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CEMIP mRNA28522335
C519728archazolid Barchazolid B results in increased expression of CEMIP mRNA25218289
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CEMIP mRNA20064835|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CEMIP mRNA26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CEMIP mRNA"26238291
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of CEMIP mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of CEMIP mRNA24758408
D004958EstradiolEstradiol results in increased expression of CEMIP mRNA21795739
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of CEMIP mRNA]21795739
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CEMIP mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CEMIP mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of CEMIP mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CEMIP mRNA26079696
C584509C646 compoundC646 compound results in increased expression of CEMIP mRNA26191083
C031639caprylic aldehydecaprylic aldehyde results in increased expression of CEMIP mRNA25014914
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CEMIP mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CEMIP mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of CEMIP mRNA25562108
D003561CytarabineCytarabine results in decreased expression of CEMIP mRNA21198554
D003907DexamethasoneDexamethasone results in decreased expression of CEMIP mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CEMIP mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CEMIP mRNA28628672
D002945CisplatinCisplatin results in decreased expression of CEMIP mRNA19561079
C000944dicrotophosdicrotophos results in increased expression of CEMIP mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of CEMIP mRNA16002434|2648566
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CEMIP mRNA24690739
C540355fenamidonefenamidone results in increased expression of CEMIP mRNA27029645
C007738fluoranthenefluoranthene results in decreased expression of CEMIP mRNA28329830
C046204heptanalheptanal results in increased expression of CEMIP mRNA25014914
C492448ICG 001ICG 001 results in increased expression of CEMIP mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CEMIP mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CEMIP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CEMIP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CEMIP mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CEMIP mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CEMIP mRNA27432991
C045463leflunomideleflunomide results in increased expression of CEMIP mRNA28988120
D009532NickelNickel results in increased expression of CEMIP mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of CEMIP mRNA27935865
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CEMIP mRNA20971185
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of CEMIP mRNA24888373
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CEMIP mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of CEMIP mRNA19095052
C046012pentanalpentanal results in increased expression of CEMIP mRNA25014914|2607969
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CEMIP mRNA28511854
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of CEMIP mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of CEMIP mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of CEMIP mRNA24888373
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of CEMIP mRNA]21795739
C005556propionaldehydepropionaldehyde results in increased expression of CEMIP mRNA25014914|2607969
D011441PropylthiouracilPropylthiouracil results in increased expression of CEMIP mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CEMIP mRNA27029645
D011794QuercetinQuercetin affects the expression of CEMIP mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CEMIP mRNA25895662
D012834SilverSilver results in decreased expression of CEMIP mRNA26014281
D012834SilverSilver results in decreased expression of CEMIP mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of CEMIP mRNA25493608
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CEMIP mRNA20106945|2163298
C024746tobacco tartobacco tar results in decreased expression of CEMIP mRNA19559774
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CEMIP mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CEMIP mRNA29024780
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CEMIP gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004415hyalurononglucosaminidase activity-IMP23509262  
GO:0004415hyalurononglucosaminidase activity-TAS-  
GO:0005515protein binding-IPI23990668  
GO:0005540hyaluronic acid binding-IDA23509262  
GO:0032050clathrin heavy chain binding-IDA23509262  
GO:0046923ER retention sequence binding-IDA23990668  
GO ID GO Term Qualifier Evidence PubMed
GO:0007605sensory perception of sound-IMP14577002  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-IDA23990668  
GO:0030213hyaluronan biosynthetic process-TAS-  
GO:0030214hyaluronan catabolic process-IMP23509262  
GO:0030335positive regulation of cell migration-IDA23990668  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IDA23990668  
GO:0090314positive regulation of protein targeting to membrane-IDA23990668  
GO:1900020positive regulation of protein kinase C activity-IDA23990668  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IDA16157444  23509262  23990668  
GO:0005737cytoplasm-IMP14577002  
GO:0005783endoplasmic reticulum-IDA23990668  
GO:0005886plasma membrane-IDA23509262  
GO:0005905clathrin-coated pit-IEA-  
GO:0030665clathrin-coated vesicle membrane-IEA-  
GO:0045334clathrin-coated endocytic vesicle-IDA23509262  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-2142845Hyaluronan metabolismTAS
R-HSA-2142850Hyaluronan biosynthesis and exportTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal